Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up‐regulating cyclooxygenase‐2 expression

Background and purpose:  Activation of muscarinic M3 mucarinic acetylcholine receptors (M3‐mAChRs) has been previously shown to confer short‐term cardioprotection against ischaemic injuries. However, it is not known whether activation of these receptors can provide delayed cardioprotection. Consequently, the present study was undertaken to investigate whether stimulation of M3‐mAChRs can induce delayed preconditioning in rats, and to characterize the potential mechanism.

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