N-(5-Bromo-2-chlorobenzyl)-N-cyclopropylnaphthalene-2-sulfonamide

In the title compound, C20H17BrClNO2S, the dihedral angle between the benzene ring and the naphthalene plane is 8.95 (8)°. The crystal packing is stabilized by weak intermolecular C—H⋯O, C—H⋯Cl and π–π [centroid–centroid distance = 3.8782 (16) Å] interactions.

[1]  T. Nagasu,et al.  Novel sulfonamides as potential, systemically active antitumor agents. , 1992, Journal of medicinal chemistry.

[2]  T. Maren,et al.  Relatons between structure and biological activity of sulfonamides. , 1976, Annual review of pharmacology and toxicology.

[3]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[4]  G. Sheldrick.  A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[5]  C. Koboldt,et al.  1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. , 1995, Journal of medicinal chemistry.

[6]  V. Manivannan,et al.  2,4-Dinitro-1-naphthyl 4-toluenesulfonate , 2008, Acta crystallographica. Section E, Structure reports online.

[7]  Raymond E. Davis,et al.  Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals , 1995 .

[8]  Helen P. Kavitha,et al.  3-Aminophenyl naphthalene-1-sulfonate , 2008, Acta crystallographica. Section E, Structure reports online.