Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

[1]  S. Sparrow,et al.  Vineland Adaptive Behavior Scales , 2020, Definitions.

[2]  R. Britton,et al.  Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder , 2019, Neuron.

[3]  S. Jaffrey,et al.  Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease , 2018, Nature Reviews Neuroscience.

[4]  A. Morgan,et al.  Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians , 2018, Journal of paediatrics and child health.

[5]  W. Sossin,et al.  Translational Control in the Brain in Health and Disease. , 2018, Cold Spring Harbor perspectives in biology.

[6]  O. Mühlemann,et al.  Nonsense-Mediated mRNA Decay Begins Where Translation Ends. , 2018, Cold Spring Harbor perspectives in biology.

[7]  D. Wechsler.  Wechsler Abbreviated Scale of Intelligence--Second Edition , 2018 .

[8]  Evelina Fedorenko,et al.  Deep phenotyping of speech and language skills in individuals with 16p11.2 deletion , 2018, European Journal of Human Genetics.

[9]  J. Gécz,et al.  A Upf3b-mutant mouse model with behavioral and neurogenesis defects , 2017, Molecular Psychiatry.

[10]  Sheena Reilly,et al.  Who to Refer for Speech Therapy at 4 Years of Age Versus Who to “Watch and Wait”? , 2017, The Journal of pediatrics.

[11]  D. Silver,et al.  The exon junction complex in neural development and neurodevelopmental disease , 2016, International Journal of Developmental Neuroscience.

[12]  G. S. Wilkinson,et al.  Wide Range Achievement Test 4 , 2016 .

[13]  Paul D. Thomas,et al.  PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation , 2016, Bioinform..

[14]  Gonzalo Viana Di Prisco,et al.  Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring , 2016, Cell.

[15]  T. Bourgeron,et al.  Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication , 2016, Journal of visualized experiments : JoVE.

[16]  P. Striano,et al.  Characterisation of CASPR2 deficiency disorder - a syndrome involving autism, epilepsy and language impairment , 2015, bioRxiv.

[17]  F. He,et al.  Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story. , 2015, Annual review of genetics.

[18]  Mriganka Sur,et al.  Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders , 2015, Science.

[19]  B. Milner,et al.  Loss of recent memory after bilateral hippocampal lesions: memory and memories—looking back and looking forward , 2015, Journal of Neurology, Neurosurgery & Psychiatry.

[20]  M. Wilkinson,et al.  The unfolded protein response is shaped by the NMD pathway , 2015, EMBO reports.

[21]  J. Gécz,et al.  Nonsense-mediated mRNA decay: Inter-individual variability and human disease , 2014, Neuroscience & Biobehavioral Reviews.

[22]  Wei Huang,et al.  Translational control in synaptic plasticity and cognitive dysfunction. , 2014, Annual review of neuroscience.

[23]  John O. Willis,et al.  Wechsler Abbreviated Scale of Intelligence , 2014 .

[24]  Jamie Zibulsky,et al.  Clinical Evaluation of Language Fundamentals, Fourth Edition , 2014 .

[25]  M. Metzstein,et al.  In Vivo Determination of Direct Targets of the Nonsense-Mediated Decay Pathway in Drosophila , 2014, G3: Genes, Genomes, Genetics.

[26]  L. Maquat,et al.  Organizing principles of mammalian nonsense-mediated mRNA decay. , 2013, Annual review of genetics.

[27]  M. Scattoni,et al.  Behavioural methods used in rodent models of autism spectrum disorders: Current standards and new developments , 2013, Behavioural Brain Research.

[28]  Y. Zheng,et al.  Exome sequencing identifies UPF3B as the causative gene for a Chinese non‐syndrome mental retardation pedigree , 2013, Clinical genetics.

[29]  J. Rosenfeld,et al.  Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. , 2013, Human molecular genetics.

[30]  A. Zarzuelo,et al.  Minocycline: far beyond an antibiotic , 2013, British journal of pharmacology.

[31]  K. Krnjević,et al.  mTORC2 controls actin polymerization required for consolidation of long-term memory , 2013, Nature Neuroscience.

[32]  L. Al-Ayadhi,et al.  The link between some alleles on human leukocyte antigen system and autism in children , 2013, Journal of Neuroimmunology.

[33]  J. Gécz,et al.  Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability , 2012, Molecular Psychiatry.

[34]  Allan Jacobson,et al.  NMD: a multifaceted response to premature translational termination , 2012, Nature Reviews Molecular Cell Biology.

[35]  K. Ríha,et al.  Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response , 2012, Nucleic acids research.

[36]  Eric P Hoffman,et al.  Genomics, intellectual disability, and autism. , 2012, The New England journal of medicine.

[37]  Wei Huang,et al.  Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition , 2011, Cell.

[38]  J. A. Al Wakeel,et al.  Comparison of high and low dose of cyclophosphamide in lupus nephritis patients: a long-term randomized controlled trial. , 2011, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.

[39]  H. Firth,et al.  The Deciphering Developmental Disorders (DDD) study , 2011, Developmental medicine and child neurology.

[40]  B. Tomblin,et al.  Co-morbidity of autism and SLI: kinds, kin and complexity. , 2011, International journal of language & communication disorders.

[41]  Todd E. Scheetz,et al.  Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with α-tectorin and is mutated in autosomal dominant hearing loss (DFNA4) , 2011, Proceedings of the National Academy of Sciences.

[42]  P. Avery,et al.  Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. , 2011, RNA.

[43]  S. Kozma,et al.  Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage , 2011, Proceedings of the National Academy of Sciences.

[44]  Lina A. Thoren,et al.  UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration , 2010, PloS one.

[45]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[46]  J. Gécz,et al.  Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism , 2010, Molecular Psychiatry.

[47]  E. Gilboa,et al.  Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay , 2010, Nature.

[48]  C. Drew.  Vineland Adaptive Behavior Scales , 2010 .

[49]  Constance Scharff,et al.  FOXP2 as a molecular window into speech and language. , 2009, Trends in genetics : TIG.

[50]  N. Sonenberg,et al.  Translational Control of Long-Lasting Synaptic Plasticity and Memory , 2009, Neuron.

[51]  Michael P. Stryker,et al.  Reversing Neurodevelopmental Disorders in Adults , 2008, Neuron.

[52]  P. Mccabe,et al.  Requests for clarification and children's speech responses: Changing `pasghetti' to `spaghetti' , 2008 .

[53]  M. Calabrese,et al.  Cyclophosphamide-based combination therapies for autoimmunity , 2008, Neurological Sciences.

[54]  Matthew Mort,et al.  A meta‐analysis of nonsense mutations causing human genetic disease , 2008, Human mutation.

[55]  Lina A. Thoren,et al.  NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. , 2008, Genes & development.

[56]  J. Vogel,et al.  Characterization of the role of ribonucleases in Salmonella small RNA decay , 2007, Nucleic acids research.

[57]  J. Gécz,et al.  Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation , 2007, Nature Genetics.

[58]  Rickard Sandberg,et al.  Improved precision and accuracy for microarrays using updated probe set definitions , 2007, BMC Bioinformatics.

[59]  M. Metzstein,et al.  Functions of the Nonsense-Mediated mRNA Decay Pathway in Drosophila Development , 2006, PLoS genetics.

[60]  R. Myers,et al.  Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data , 2005, Nucleic acids research.

[61]  P. Bork,et al.  Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. , 2005, RNA.

[62]  E. Klann,et al.  Biochemical mechanisms for translational regulation in synaptic plasticity , 2004, Nature Reviews Neuroscience.

[63]  Francisco Martinez-Murillo,et al.  Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise , 2004, Nature Genetics.

[64]  Carla J. Shatz,et al.  Immune signalling in neural development, synaptic plasticity and disease , 2004, Nature Reviews Neuroscience.

[65]  Roy Parker,et al.  Nonsense-mediated mRNA decay: terminating erroneous gene expression. , 2004, Current opinion in cell biology.

[66]  Richard Simon,et al.  A random variance model for detection of differential gene expression in small microarray experiments , 2003, Bioinform..

[67]  E. Kandel.  The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses , 2001, Science.

[68]  L. Maquat,et al.  Evidence for a Pioneer Round of mRNA Translation mRNAs Subject to Nonsense-Mediated Decay in Mammalian Cells Are Bound by CBP80 and CBP20 , 2001, Cell.

[69]  J. Mendell,et al.  Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. , 2001, Human molecular genetics.

[70]  S. Zeitlin,et al.  CaMKIIα‐cre transgene expression and recombination patterns in the mouse brain , 2000 .

[71]  S. Tonegawa,et al.  The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory , 1996, Cell.

[72]  T. Préat,et al.  Genetic dissection of consolidated memory in Drosophila , 1994, Cell.

[73]  Robert C. Malenka,et al.  Synaptic plasticity in the hippocampus: LTP and LTD , 1994, Cell.

[74]  T. Klee,et al.  Clinical assessment of oropharyngeal motor development in young children. , 1987, The Journal of speech and hearing disorders.

[75]  Heidemarie Neitzel,et al.  A routine method for the establishment of permanent growing lymphoblastoid cell lines , 1986, Human Genetics.

[76]  S. Fisher,et al.  Early speech development in Koolen de Vries syndrome limited by oral praxis and hypotonia , 2017, European Journal of Human Genetics.

[77]  E. Kandel,et al.  The regulation of transcription in memory consolidation. , 2014, Cold Spring Harbor perspectives in biology.

[78]  Richard J. Jones,et al.  Repeated treatment with high dose cyclophosphamide for severe autoimmune diseases. , 2013, American journal of blood research.

[79]  Guilherme Neves,et al.  Synaptic plasticity, memory and the hippocampus: a neural network approach to causality , 2008, Nature Reviews Neuroscience.

[80]  J. Rawlins,et al.  T-maze alternation in the rodent , 2006, Nature Protocols.

[81]  B. Dodd,et al.  Diagnostic Evaluation of Articulation and Phonology , 2002 .

[82]  Alcino J. Silva,et al.  CREB and memory. , 1998, Annual review of neuroscience.

[83]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .