Oxidative stress and the mitochondrial theory of aging in human skeletal muscle

[1]  P. Mecocci,et al.  Age and sex influence on oxidative damage and functional status in human skeletal muscle , 2004, Journal of Muscle Research & Cell Motility.

[2]  A. Linnane,et al.  Age-related atrophy of rat soleus muscle is accompanied by changes in fibre type composition, bioenergy decline and mtDNA rearrangements , 2004, Biogerontology.

[3]  Chunfang Zhang,et al.  Stochastic mitochondrial DNA changes: bioenergy decline in type I skeletal muscle fibres correlates with a decline in the amount of amplifiable full-length mtDNA , 2004, Biogerontology.

[4]  P. Krustrup,et al.  Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondria , 2003, Experimental Gerontology.

[5]  M. Fardeau,et al.  Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function , 2002, Neuromuscular Disorders.

[6]  M. Beal,et al.  High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. , 2002, Human molecular genetics.

[7]  H. Naito,et al.  Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle , 2002, Pflügers Archiv.

[8]  S. McKiernan,et al.  Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. , 2001, Nucleic acids research.

[9]  Zhongmao Guo,et al.  Does oxidative damage to DNA increase with age? , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. Tarnopolsky,et al.  Substrate utilization during endurance exercise in men and women after endurance training. , 2001, American journal of physiology. Endocrinology and metabolism.

[11]  M. Tarnopolsky,et al.  Creatine transporter and mitochondrial creatine kinase protein content in myopathies , 2001, Muscle & nerve.

[12]  J. Aiken,et al.  Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  D. Murdock,et al.  The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. , 2000, Nucleic acids research.

[14]  Ò. Miró,et al.  Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. , 2000, Cardiovascular research.

[15]  A. Francavilla,et al.  MtDNA Deletions in Aging and in Nonmitochondrial Pathologies , 2000, Annals of the New York Academy of Sciences.

[16]  K. Nair,et al.  Effects of Aging on Mitochondrial DNA Copy Number and Cytochromec Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart* , 2000, The Journal of Biological Chemistry.

[17]  O. Pansarasa,et al.  Age and sex differences in human skeletal muscle: Role of reactive oxygen species , 2000, Free radical research.

[18]  O. Pansarasa,et al.  Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. , 1999, Free radical biology & medicine.

[19]  P. Mecocci,et al.  Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. , 1999, Free radical biology & medicine.

[20]  A. Linnane,et al.  Total Extent and Cellular Distribution of Mitochondrial DNA Mutations in Aging , 1998, Annals of the New York Academy of Sciences.

[21]  P. Nagley,et al.  Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing. , 1998, Nucleic acids research.

[22]  Margaret A. Johnson,et al.  Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle , 1998, Annals of neurology.

[23]  A. Munnich,et al.  Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. , 1998, The Biochemical journal.

[24]  P. Nagley,et al.  Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging , 1998, Human mutation.

[25]  H.C. Lee,et al.  Role of Mitochondria in Human Aging. , 1997, Journal of biomedical science.

[26]  A. Linnane,et al.  Deltoid human muscle mtDNA is extensively rearranged in old age subjects. , 1997, Biochemical and biophysical research communications.

[27]  Ò. Miró,et al.  Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. , 1996, Biochemical and biophysical research communications.

[28]  E. Schon,et al.  Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR. , 1996, Methods in enzymology.

[29]  R. Weindruch,et al.  Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. , 1996, Developmental genetics.

[30]  G. Lenaz,et al.  Human skeletal muscle mitochondria in aging: lack of detectable morphological and enzymic defects. , 1995, Biochemistry and molecular biology international.

[31]  R. Weindruch,et al.  High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys , 1995, Mechanisms of Ageing and Development.

[32]  G. Attardi,et al.  Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. , 1995, Biochimica et biophysica acta.

[33]  S. Melov,et al.  Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. , 1995, Nucleic acids research.

[34]  S. Papa,et al.  Decline with age of the respiratory chain activity in human skeletal muscle. , 1994, Biochimica et biophysica acta.

[35]  R. Hsieh,et al.  Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. , 1994, Biochemistry and molecular biology international.

[36]  C. Münscher,et al.  Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. , 1993, Biological chemistry Hoppe-Seyler.

[37]  P. Nagley,et al.  Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. , 1993, Biochemical and biophysical research communications.

[38]  L. Ji.  Antioxidant enzyme response to exercise and aging. , 1993, Medicine and science in sports and exercise.

[39]  S. Dimauro,et al.  Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. , 1992, Biochimica et biophysica acta.

[40]  D. Shibata,et al.  A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[41]  片山 信.  Deleted mitochondrial DNA in the skeletal muscle of aged individuals , 1992 .

[42]  S. Marzuki,et al.  Mitochondrial gene mutation: the ageing process and degenerative diseases. , 1990, Biochemistry international.

[43]  E. Stadtman,et al.  Determination of carbonyl content in oxidatively modified proteins. , 1990, Methods in enzymology.

[44]  N. Arnheim,et al.  Detection of a specific mitochondrial DNA deletion in tissues of older humans. , 1990, Nucleic acids research.

[45]  R. Cussó,et al.  DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATION CHAIN FUNCTION WITH AGEING , 1989, The Lancet.

[46]  Edward Byrne,et al.  DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING , 1989, The Lancet.

[47]  J. Holloszy,et al.  Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. , 1985, Journal of gerontology.

[48]  I. Fridovich,et al.  Permeation of the erythrocyte stroma by superoxide radical. , 1978, The Journal of biological chemistry.

[49]  T. Deeley,et al.  Letter: Cancer detection. , 1976, Lancet.

[50]  H. Waldron,et al.  Letter: Blood-lead levels, behaviour, and intelligence. , 1974, Lancet.

[51]  Denham Harman,et al.  The Biologic Clock: The Mitochondria? , 1972, Journal of the American Geriatrics Society.