The effect of nonzero second-order interaction on combined estimators of the odds ratio

SUMMARY In combining odds ratios across strata, the assumption of zero second-order interaction is usually made in order to simplify estimation. The implications for the use of the general logistic model, when this assumption is not met, are considered. Using Monte Carlo techniques, the effect of nonzero second-order interaction on five available combined estimators is considered and an attempt made to provide results applicable in a variety of research situations.

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