Effects of additives on laser-assisted fibrinogen bonding

In order to produce a solder for Laser-Assisted Tissue Bonding (LATB) with better tactile characteristics and shelf life, plasma-derived fibrinogen concentrate has been augmented with various additives, including anionic polysaccharides, anti-fibrinolytic agents, and preservatives. For comparison of this new, compounded 'solder' with the pure, plasma- derived fibrinogen concentrate an in vivo tissue 'weld' assay was devised. While further analyses must be done to assess more critical healing time periods and characteristics, this study is an affirmation that the plasma-derived, protein concentrates, with or without certain additives, offer effective alternatives to suture repair.