use and metabolic side effects expression: clues to the association between valproate Valproate-induced alterations in human theca cell gene

[1]  V. Kusumakar,et al.  Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder. , 2002, The Journal of clinical psychiatry.

[2]  Xiaohua Li,et al.  Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium , 2002, Neuropharmacology.

[3]  M. Birnbaum,et al.  Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport , 1999, Annals of the New York Academy of Sciences.

[4]  Ping Zhu,et al.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.

[5]  Marc Montminy,et al.  PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 , 2004, Nature Medicine.

[6]  R. Legro,et al.  Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. , 1999, Molecular endocrinology.

[7]  W. Miller,et al.  P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5. , 1999, Molecular endocrinology.

[8]  H. Manji,et al.  The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth* , 2001, The Journal of Biological Chemistry.

[9]  Marc Montminy,et al.  TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver , 2003, Science.

[10]  M. Urbanek,et al.  The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis* , 2003, Journal of Biological Chemistry.

[11]  H. Manji,et al.  Valproate robustly enhances AP-1 mediated gene expression. , 1999, Brain research. Molecular brain research.

[12]  L. Giudice,et al.  Predictors of ovulatory failure in women with epilepsy , 2002, Annals of neurology.

[13]  A. Dunaif,et al.  Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. , 1997, Endocrine reviews.

[14]  Xiaodong Cheng,et al.  Differential Signaling of Cyclic AMP , 2002, The Journal of Biological Chemistry.

[15]  V. Asghari,et al.  Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells. , 1998, Brain research. Molecular brain research.

[16]  T. Unterman,et al.  Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via phosphatidylinositol 3-kinase in porcine granulosa cells. , 2003, Endocrinology.

[17]  R. DePinho,et al.  Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a , 2003, Science.

[18]  J. Winnie,et al.  Invasion of v-FosFBR-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes , 2004, Oncogene.

[19]  S. R. Datta,et al.  Cellular survival: a play in three Akts. , 1999, Genes & development.

[20]  A. Makrigiannakis,et al.  Insulin and insulin-like growth factor-I and -II modulate human granulosa-lutein cell steroidogenesis: enhancement of steroidogenic acute regulatory protein (StAR) expression. , 1999, Molecular human reproduction.

[21]  Rama Natarajan,et al.  In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions* , 2004, Journal of Biological Chemistry.

[22]  T. Betts,et al.  A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy , 2003, Seizure.

[23]  G. Firestone,et al.  Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells. , 2000, Molecular endocrinology.

[24]  Jun-Feng Wang,et al.  Glutathione S‐transferase is a novel target for mood stabilizing drugs in primary cultured neurons , 2004, Journal of neurochemistry.

[25]  E. Trinka,et al.  Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate , 2002, Epilepsy Research.

[26]  Martha Morrell,et al.  Reproductive and Metabolic Disorders in Women with Epilepsy , 2003, Epilepsia.

[27]  A. V. van Kuilenburg,et al.  Histone deacetylases (HDACs): characterization of the classical HDAC family. , 2003, The Biochemical journal.

[28]  M. Knip,et al.  Altered ovarian function and cardiovascular risk factors in valproate-treated women. , 2001, The American journal of medicine.

[29]  R. Lenox,et al.  A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity , 2002, Brain Research.

[30]  K. M. Nicholson,et al.  The protein kinase B/Akt signalling pathway in human malignancy. , 2002, Cellular signalling.

[31]  P. Wade.  Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin. , 2001, Human molecular genetics.

[32]  Yang Shi,et al.  Ineffectiveness of Histone Deacetylase Inhibitors to Induce Apoptosis Involves the Transcriptional Activation of NF-κB through the Akt Pathway* , 2003, Journal of Biological Chemistry.

[33]  J. Veldhuis,et al.  Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells: joint amplification of pivotal sterol-regulatory genes encoding the low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory (StAR) protein and cytochrome P450 side-chain clea , 2000, Molecular and Cellular Endocrinology.

[34]  H. Manev,et al.  Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus , 2003, Neuroscience Letters.

[35]  T. Shibasaki,et al.  Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion* , 2001, The Journal of Biological Chemistry.

[36]  J. Veldhuis,et al.  Interactive Stimulation by Luteinizing Hormone and Insulin of the Steroidogenic Acute Regulatory (StAR) Protein and 17α-Hydroxylase/17, 20-Lyase (CYP17) Genes in Porcine Theca Cells. , 2000, Endocrinology.

[37]  Z. Rosenwaks,et al.  Phosphatidyl-inositol-3 kinase-independent insulin action pathway(s) in the human ovary. , 2001, The Journal of clinical endocrinology and metabolism.

[38]  H. Nau,et al.  Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives. , 2001, Molecular pharmacology.

[39]  C. Nappi,et al.  Characterization of reproductive endocrine disorders in women with epilepsy. , 2001, The Journal of clinical endocrinology and metabolism.

[40]  A. Dunaif.  Insulin action in the polycystic ovary syndrome. , 1999, Endocrinology and metabolism clinics of North America.

[41]  H. Nau,et al.  Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. , 2001, European journal of pharmacology.

[42]  P. G. Quinn,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Differential Activity of the Cytochrome P450 17�- Hydroxylase and Steroidogenic Acute Regulatory Protein Gene Promoters in Normal and Polycystic , 2022 .

[43]  M. Guenther,et al.  Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.

[44]  C. Johannessen,et al.  Mechanisms of action of valproate: a commentatory , 2000, Neurochemistry International.

[45]  J. Wood,et al.  Valproate potentiates androgen biosynthesis in human ovarian theca cells. , 2004, Endocrinology.

[46]  M. Cunningham,et al.  FoxO1a can alter cell cycle progression by regulating the nuclear localization of p27kip in granulosa cells. , 2004, Molecular endocrinology.

[47]  P. S. Klein,et al.  Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. , 2002, Pharmacology & therapeutics.

[48]  M. Urbanek,et al.  Phenotype and genotype in polycystic ovary syndrome. , 1998, Recent progress in hormone research.