Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease

Rest tremor is a cardinal symptom of Parkinson's disease (PD), and is readily suppressed by deep brain stimulation (DBS) of the subthalamic nucleus (STN). The therapeutic effect of the latter on bradykinesia and rigidity has been associated with the suppression of exaggerated beta (13–30 Hz) band synchronization in the vicinity of the stimulating electrode, but there is no correlation between beta suppression and tremor amplitude. In the present study, we investigate whether tremor suppression is related to suppression of activities at other frequencies.

[1]  W. A. Taylor.  Change-Point Analysis : A Powerful New Tool For Detecting Changes , 2000 .

[2]  Nicola J. Ray,et al.  Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation , 2008, Experimental Neurology.

[3]  Andrea A. Kühn,et al.  The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease , 2005, Experimental Neurology.

[4]  J. Henderson,et al.  High frequency deep brain stimulation attenuates subthalamic and cortical rhythms in Parkinson's disease , 2012, Front. Hum. Neurosci..

[5]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[6]  P. Brown,et al.  Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization , 2010, Neuroscience.

[7]  Anne Boomsma,et al.  On the structure of motor symptoms of Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[8]  J. Dostrovsky,et al.  Increased gamma oscillatory activity in the subthalamic nucleus during tremor in Parkinson's disease patients. , 2009, Journal of neurophysiology.

[9]  P. Brown,et al.  Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[10]  J. Dostrovsky,et al.  High-frequency Synchronization of Neuronal Activity in the Subthalamic Nucleus of Parkinsonian Patients with Limb Tremor , 2000, The Journal of Neuroscience.

[11]  Peter Brown,et al.  A gamma band specific role of the subthalamic nucleus in switching during verbal fluency tasks in Parkinson’s disease , 2011, Experimental Neurology.

[12]  E. Růžička,et al.  The Subthalamic Microlesion Story in Parkinson's Disease: Electrode Insertion-Related Motor Improvement with Relative Cortico-Subcortical Hypoactivation in fMRI , 2012, PloS one.

[13]  J. Dostrovsky,et al.  Synchronized Neuronal Discharge in the Basal Ganglia of Parkinsonian Patients Is Limited to Oscillatory Activity , 2002, The Journal of Neuroscience.

[14]  M. Butz,et al.  A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease. , 2013, Brain : a journal of neurology.

[15]  Thomas Foltynie,et al.  Surgical management of Parkinson’s disease , 2010, Expert review of neurotherapeutics.

[16]  A. Priori,et al.  An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation , 2007, Journal of neural engineering.

[17]  Tipu Aziz,et al.  Complementary roles of different oscillatory activities in the subthalamic nucleus in coding motor effort in Parkinsonism☆ , 2013, Experimental Neurology.

[18]  Andrea A. Kühn,et al.  Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity , 2009, Experimental Neurology.

[19]  Christian R Baumann,et al.  Epidemiology, diagnosis and differential diagnosis in Parkinson's disease tremor. , 2012, Parkinsonism & related disorders.

[20]  K. Sigvardt,et al.  Temporal evolution of oscillations and synchrony in GPi/muscle pairs in Parkinson's disease. , 2005, Journal of neurophysiology.

[21]  Pedram Afshar,et al.  Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate , 2014, Journal of neural engineering.

[22]  J. Dostrovsky,et al.  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. , 2006, Journal of neurophysiology.

[23]  Ned Jenkinson,et al.  Subthalamic Nucleus Local Field Potential Activity during the Eriksen Flanker Task Reveals a Novel Role for Theta Phase during Conflict Monitoring , 2013, The Journal of Neuroscience.

[24]  N. Thakor,et al.  Spectral analysis methods for neurological signals , 1998, Journal of Neuroscience Methods.

[25]  M. Brin,et al.  Consensus Statement of the Movement Disorder Society on Tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[26]  K. Jellinger.  Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms? , 1999, Journal of neural transmission. Supplementum.

[27]  H. Freund,et al.  The cerebral oscillatory network of parkinsonian resting tremor. , 2003, Brain : a journal of neurology.

[28]  Matthew D. Johnson,et al.  In vivo impedance spectroscopy of deep brain stimulation electrodes , 2009, Journal of neural engineering.

[29]  O. Hornykiewicz.  Dopamine (3-hydroxytyramine) and brain function. , 1966, Pharmacological reviews.

[30]  Tipu Aziz,et al.  Frequency specific activity in subthalamic nucleus correlates with hand bradykinesia in Parkinson's disease , 2013, Experimental Neurology.

[31]  Peter Brown,et al.  Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: A study of random number generation in Parkinson's disease , 2013, NeuroImage.

[32]  J. Dostrovsky,et al.  Beta oscillatory neurons in the motor thalamus of movement disorder and pain patients , 2014, Experimental Neurology.

[33]  Guglielmo Foffani,et al.  Time dependent subthalamic local field potential changes after DBS surgery in Parkinson's disease , 2010, Experimental Neurology.

[34]  P. Brown,et al.  Annals of the New York Academy of Sciences What Brain Signals Are Suitable for Feedback Control of Deep Brain Stimulation in Parkinson's Disease? , 2022 .

[35]  S. Groiss,et al.  Characterisation of tremor‐associated local field potentials in the subthalamic nucleus in Parkinson’s disease , 2009, The European journal of neuroscience.

[36]  Alexander L Green,et al.  Subthalamic nucleus activity optimizes maximal effort motor responses in Parkinson's disease. , 2012, Brain : a journal of neurology.

[37]  N. Ince,et al.  Long-term recordings of local field potentials from implanted deep brain stimulation electrodes. , 2012, Neurosurgery.

[38]  P. Brown,et al.  Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease , 2006, The European journal of neuroscience.