Adrenocortical carcinoma: the range of appearances on CT and MRI.

OBJECTIVE Adrenocortical carcinoma (ACC) is a rare, aggressive tumor arising from the adrenal cortex that typically presents late with a large mass. The increased use of cross-sectional imaging for unrelated reasons has led to a greater number of ACCs being detected incidentally at an earlier stage. Recognition of the typical clinical, biochemical, and imaging findings is imperative for rapid diagnosis, prompt intervention, and early use of the appropriate therapy. CONCLUSION Cross-sectional imaging with CT and MRI is essential for determining the extent of local and distant tumor spread. Complete surgical resection is currently the only potentially curative treatment of ACC, and the information attained from CT and MRI is important to guide surgery and further patient management.

[1]  P. Bhosale,et al.  Current update on cytogenetics, taxonomy, diagnosis, and management of adrenocortical carcinoma: what radiologists should know. , 2012, AJR. American journal of roentgenology.

[2]  R. Conran,et al.  From the radiologic pathology archives: precocious puberty: radiologic-pathologic correlation. , 2012, Radiographics : a review publication of the Radiological Society of North America, Inc.

[3]  G. Low,et al.  Clinical and imaging overview of functional adrenal neoplasms , 2012, International journal of urology : official journal of the Japanese Urological Association.

[4]  E. Siegelman Adrenal MRI: Techniques and clinical applications , 2012, Journal of magnetic resonance imaging : JMRI.

[5]  Paul Nikolaidis,et al.  Adrenal imaging: a comprehensive review. , 2012, Radiologic clinics of North America.

[6]  M. Fassnacht,et al.  Contemporary management of adrenocortical carcinoma. , 2011, European urology.

[7]  L. Sobin,et al.  Adrenal Cortex Tumours , 2010 .

[8]  F. Montorsi,et al.  The European Network for the Study of Adrenal Tumors staging system is prognostically superior to the international union against cancer-staging system: a North American validation. , 2010, European journal of cancer.

[9]  P. Narayanan Primary Adrenal Malignancy , 2009 .

[10]  W. Kenn,et al.  Radiotherapy in adrenocortical carcinoma , 2009, Cancer.

[11]  M. Korobkin,et al.  Contemporary imaging of incidentally discovered adrenal masses , 2009, Nature Reviews Urology.

[12]  L. Weiss,et al.  The Weiss system for evaluating adrenocortical neoplasms: 25 years later. , 2009, Human pathology.

[13]  S. Chua,et al.  Imaging features of primary extranodal lymphomas. , 2009, Clinical radiology.

[14]  K. Pacak,et al.  Clinical aspects of SDHx-related pheochromocytoma and paraganglioma. , 2009, Endocrine-related cancer.

[15]  M. Bienvenu,et al.  18F-Fluorodeoxyglucose positron emission tomography for the diagnosis of adrenocortical tumors: a prospective study in 77 operated patients. , 2009, The Journal of clinical endocrinology and metabolism.

[16]  Martin Fassnacht,et al.  Clinical management of adrenocortical carcinoma. , 2009, Best practice & research. Clinical endocrinology & metabolism.

[17]  N. Holalkere,et al.  PET/CT for the characterization of adrenal masses in patients with cancer: qualitative versus quantitative accuracy in 150 consecutive patients. , 2009, AJR. American journal of roentgenology.

[18]  R. Kreis,et al.  Insufficient spectral quality to draw conclusions. , 2009, Radiology.

[19]  F. Beuschlein,et al.  Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma , 2009, Cancer.

[20]  D. Bentrem,et al.  Adrenocortical carcinoma in the United States , 2008, Cancer.

[21]  R. Reznek,et al.  123I‐metaiodobenzylguanidine (MIBG) scintigraphy for the detection of adrenal and extra‐adrenal phaeochromocytomas: CT and MRI correlation , 2008, Clinical endocrinology.

[22]  D. Berney,et al.  Adrenal phaeochromocytoma: correlation of MRI appearances with histology and function , 2008, European Radiology.

[23]  Hong Li,et al.  Bilateral adrenal tumor: causes and clinical features in eighteen cases , 2008, International Urology and Nephrology.

[24]  P. Kenney,et al.  Adrenal masses: characterization with in vivo proton MR spectroscopy--initial experience. , 2007, Radiology.

[25]  R. Reznek,et al.  The optimal imaging of adrenal tumours: a comparison of different methods. , 2007, Endocrine-related cancer.

[26]  B. K. Park,et al.  Re-evaluation of pheochromocytomas on delayed contrast-enhanced CT: washout enhancement and other imaging features , 2007, European Radiology.

[27]  Melvyn Korobkin,et al.  Differentiating adrenal adenomas from nonadenomas using (18)F-FDG PET/CT: quantitative and qualitative evaluation. , 2007, Academic radiology.

[28]  W. Young The incidentally discovered adrenal mass , 2007 .

[29]  B. Herts,et al.  Incidental pheochromocytoma mimicking adrenal adenoma because of rapid contrast enhancement loss. , 2006, AJR. American journal of roentgenology.

[30]  J. Bertherat,et al.  Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients. , 2006, The Journal of clinical endocrinology and metabolism.

[31]  M. Kalra,et al.  Adrenocortical carcinoma: contrast washout characteristics on CT. , 2006, AJR. American journal of roentgenology.

[32]  Martin Fassnacht,et al.  Adrenocortical Carcinoma: Clinical Update , 2006 .

[33]  M. Bergström,et al.  [11C]metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings. , 2006, The Journal of clinical endocrinology and metabolism.

[34]  Jeffrey E. Lee,et al.  Laparoscopic resection of adrenal cortical carcinoma: a cautionary note. , 2005, Surgery.

[35]  B. Heniford,et al.  Laparoscopic adrenalectomy for malignancy. , 2005, American journal of surgery.

[36]  Andrea Berghold,et al.  Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT. , 2005, Radiology.

[37]  C. Eng,et al.  Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. , 2004, JAMA.

[38]  M. Haider,et al.  Chemical shift MR imaging of hyperattenuating (>10 HU) adrenal masses: does it still have a role? , 2004, Radiology.

[39]  W. Kenn,et al.  Adrenal tumors: How to establish malignancy? , 2004, Journal of endocrinological investigation.

[40]  R. Reznek,et al.  CT and MR imaging of the adrenal glands in ACTH-independent cushing syndrome. , 2004, Radiographics : a review publication of the Radiological Society of North America, Inc.

[41]  D. Bova,et al.  CT and MR demonstration of fat within an adrenal cortical carcinoma , 1995, Abdominal Imaging.

[42]  T. Fojo,et al.  Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases , 2003, Cancer.

[43]  Linda Ng,et al.  Adrenocortical carcinoma: diagnosis, evaluation and treatment. , 2003, The Journal of urology.

[44]  S. Jung,et al.  Neurogenic tumors in the abdomen: tumor types and imaging characteristics. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[45]  H. Ishwaran,et al.  Staging of neuroblastoma at imaging: report of the radiology diagnostic oncology group. , 2002, Radiology.

[46]  Melvyn Korobkin,et al.  Adrenal masses: characterization with combined unenhanced and delayed enhanced CT. , 2002, Radiology.

[47]  M. Lockhart,et al.  Imaging of adrenal masses. , 2002, European journal of radiology.

[48]  Richard C. Semelka,et al.  Abdominal-Pelvic MRI , 2002 .

[49]  Jeffrey E. Lee,et al.  Adrenal cortical carcinoma , 2001, World Journal of Surgery.

[50]  Y. Chapuis,et al.  Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group , 2001, World Journal of Surgery.

[51]  R B Noto,et al.  State-of-the-art adrenal imaging. , 2001, Radiographics : a review publication of the Radiological Society of North America, Inc.

[52]  A. Latronico,et al.  Adrenocortical carcinoma , 2000, Cancer.

[53]  H. Rousseau,et al.  Imaging features of uncommon adrenal masses with histopathologic correlation. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[54]  T. Krebs,et al.  MR imaging of the adrenal gland: radiologic-pathologic correlation. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[55]  J. Pelage,et al.  CT of abdominal wall implantation metastases after abdominal percutaneous procedures. , 1998, Journal of computer assisted tomography.

[56]  G. Gazelle,et al.  Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. , 1998, AJR. American journal of roentgenology.

[57]  L. Quint,et al.  CT time-attenuation washout curves of adrenal adenomas and nonadenomas. , 1998, AJR. American journal of roentgenology.

[58]  E. Fishman,et al.  Spectrum of CT findings in nonmalignant disease of the adrenal gland. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[59]  E. Fishman,et al.  Primary adrenal ganglioneuroma: CT findings in four patients. , 1997, AJR. American journal of roentgenology.

[60]  G. Chrousos,et al.  Extensive personal experience: adrenocortical tumors. , 1997, The Journal of clinical endocrinology and metabolism.

[61]  R. Kloos,et al.  Incidentally discovered adrenal masses. , 1995, Cancer treatment and research.

[62]  R. Semelka,et al.  Adrenocortical carcinoma: MR imaging appearance with current techniques , 1995, Journal of magnetic resonance imaging : JMRI.

[63]  R. Soler,et al.  MR imaging in inferior vena cava thrombosis. , 1995, European journal of radiology.

[64]  M. Wooten,et al.  Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature , 1993, Cancer.

[65]  M. Brennan,et al.  Management of adrenal neoplasms. , 1991, Current problems in surgery.

[66]  P Blondeau,et al.  Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. , 1990, The New England journal of medicine.

[67]  David A. Turner,et al.  Magnetic resonance imaging of adrenal cortical carcinoma , 1989, Urologic radiology.

[68]  E. Fishman,et al.  Primary adrenocortical carcinoma: CT evaluation with clinical correlation. , 1987, AJR. American journal of roentgenology.

[69]  L. Sobin,et al.  TNM Classification of Malignant Tumours , 1987, UICC International Union Against Cancer.

[70]  H. Hricak,et al.  Abdominal venous system: assessment using MR. , 1985, Radiology.

[71]  H. Slooten,et al.  Morphologic characteristics of benign and malignant adrenocortical tumors , 1985, Cancer.

[72]  J. Richie,et al.  Differentiation of malignant from benign adrenal masses: predictive indices on computed tomography. , 1985, AJR. American journal of roentgenology.

[73]  L. Weiss Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors , 1984, The American journal of surgical pathology.

[74]  D. Wilson,et al.  Histoplasmosis of the adrenal glands studied by CT. , 1984, Radiology.

[75]  N. Samaan,et al.  Adrenal cortical carcinoma a study of 77 cases , 1983, Cancer.

[76]  R. Halvorsen,et al.  CT Appearance of Adrenal Cortical Carcinoma , 1982, Journal of computer assisted tomography.

[77]  J. Doppman,et al.  Management of intravenous extensions of endocrine tumors and prognosis after surgical treatment. , 1980, American journal of surgery.

[78]  D. Page,et al.  Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphologic data. , 1979, American journal of clinical pathology.

[79]  M. Boileau,et al.  Adrenal cortical carcinoma. , 1978, The Journal of urology.

[80]  Hollander Cf,et al.  Tumours of the adrenal gland. , 1976 .

[81]  D. A. Macfarlane Cancer of the adrenal cortex; the natural history, prognosis and treatment in a study of fifty-five cases. , 1958, Annals of the Royal College of Surgeons of England.

[82]  Norman Goldstein,et al.  Metastases in carcinoma. Analysis of 1000 autopsied cases , 1950, Cancer.