Prospective trial evaluating immunocytochemical‐based sputum techniques for early lung cancer detection: Assays for promotion factors in the bronchial lavage

To confirm the results of a previous report on the use of monoclonal antibodies in immunocytochemical assays of sputums for the early detection of lung cancer, we designed a new prospective trial in an independent clinical trial population. Since well‐characterized Stage I resected non‐small cell lung cancer patients have a low rate of tumor relapse and a high (1–3%/year) chance of developing a second primary lung cancer, they comprise a very favorable group for conducting an early lung cancer detection trial. The rate of new lung cancer is about 10‐fold in excess of a standard “high” risk population of smokers.

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