Kinesiogenomics: The Genomic Era in Kinesiology

Genetik bilim dalinin kinesioloji alanindaki uygulamalari kinesiogenomik veya spor genetigi olarak adlandirilabilir. Bu nedenle, kinesiogenomik terimi, kinesiolojinin cesitli disiplinlerindeki genetik bilim uygulamalari olarak tanimlayabiliriz. Kinesiogenomik alaninda yurutulen arastirmalarin temel bilimsel amaci sportif performansin genetik yonlerini aciklayabilmek ve farkli genlerin farkli allelleriyle vucut sistemleri ve metabolizmasinin yanit ve uyumu uzerinde gosterdikleri etkileri aciklayabilmektir. Kinesiolojinin cesitli disiplinlerindeki genetik bilim uygulamalariyla, ayni zamanda performansinin saptanmasinda genetik testlerin kullanilmasini olasi kilacak ve sporcu performansini gelistirmeye yonelik bireysel egzersiz recetesi ve gen tedavisini beraberinde getirecektir. Maksimal oksijen kullanimi, kisa fibril tip yapisi, antrene edilebilirlik gibi bireysel ozelliklerde genetik yatkinlik agir basmaktadir. Genetik arastirmalar, sportif performansla iliskili genlerin fenotipik katkilarin aciklanmasiyla; aerobik, anaerobik kapasite, kalp ve iskelet kasi morfolojileri, kas gucu ve dayanikliligi ve sinirsel ileti ozellikleri gibi kinesiogenomik baglantili ozelliklerinin etkisiyle kinesioloji alaninda yeni gelismelere neden olmaktadir. Bugune kadar yapilan kinesiogenomik arastirmalarinda, kinesioloji alaninda alaninda genis kohortlu, fenotipi iyi belirlenmis genis katilimli gruplar uzerinde yapilan genom calisamalariyla bir yeni cag acilmistir. Bu derleme makale calismasinin amaci, kinesioloji alanindaki cesitli disiplinlerde son donemde yasanan onemli genetik uygulamalari ozetlemek ve kinesiogenomik acisindan spor bilimi ve kinesioloji alaninda gelecek icin bilimsel beklenti ve olanaklari ongormeye calismaktir

[1]  H. Gümüşdağ,et al.  GEN DOPİNGİ VE SPORTİF PERFORMANS , 2014 .

[2]  Theodore Friedmann,et al.  Gene doping in sports: the science and ethics of genetically modified athletes. , 2011, Advances in genetics.

[3]  T. Friedmann How Close Are We to Gene Doping? , 2010, The Hastings Center report.

[4]  A. Lucia,et al.  Can we identify a power-oriented polygenic profile? , 2010, Journal of applied physiology.

[5]  L. Boon,et al.  Monocytes from patients with myelodysplastic syndromes are more resistant to inhibition by thalidomide , 2009, American journal of hematology.

[6]  J. Rupert,et al.  Constructing Winners: The Science and Ethics of Genetically Manipulating Athletes , 2009 .

[7]  D. Lea Genetic and Genomic Healthcare: Ethical Issues of Importance to Nurses , 2008, OJIN: The Online Journal of Issues in Nursing.

[8]  A. Maradiegue A Resource Guide for Learning About Genetics , 2008, OJIN: The Online Journal of Issues in Nursing.

[9]  T. Brutsaert,et al.  What makes a champion? Explaining variation in human athletic performance , 2006, Respiratory Physiology & Neurobiology.

[10]  A. Miah Gene doping: the shape of things to come. , 2005 .

[11]  A. Schneider Genetic enhancement of athletic performance , 2005 .

[12]  T. Tännsjö Genetic engineering and elitism in sport , 2005 .

[13]  Claude Bouchard,et al.  The Human Obesity Gene Map: The 2005 Update , 2006, Obesity.

[14]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2005 update. , 2003 .

[15]  Lee Rust Brown,et al.  Isokinetics in Human Performance , 2000 .

[16]  H Hemingway,et al.  Human angiotensin I-converting enzyme gene and endurance performance. , 1999, Journal of applied physiology.

[17]  Bing Yu,et al.  Elite endurance athletes and the ACE I allele – the role of genes in athletic performance , 1998, Human Genetics.

[18]  Jimmy D Bell,et al.  Human gene for physical performance , 1998, Nature.

[19]  K. Goa,et al.  Losartan Potassium , 1996, Drugs.

[20]  R. L. Simon,et al.  Good competition and drug-enhanced performance. , 1984 .

[21]  C. Vega Universal Declaration on the Human Genome and Human Rights , 2013 .

[22]  Şengül Tural,et al.  Sporda Gen Dopingi , 2011 .

[23]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2004 update. , 2005, Medicine and science in sports and exercise.

[24]  C. Tamburrini Educational or genetic blueprints, what’s the difference? , 2003 .

[25]  G. Rodas,et al.  Heritability of explosive power and anaerobic capacity in humans , 2002, European Journal of Applied Physiology.

[26]  K. Goa,et al.  Losartan potassium , 1996 .