Progress in Molecularly Imprinted Polymers for Biomedical Applications.

BACKGROUND Molecularly imprinted polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications. OBJECTIVE In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed. CONCLUSION We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

[1]  Zhengpeng Yang,et al.  A novel photoelectrochemical sensor for bilirubin based on porous transparent TiO2 and molecularly imprinted polypyrrole , 2016 .

[2]  Bin Yang,et al.  Highly selective recognition and fluorescent detection of JEV via virus-imprinted magnetic silicon microspheres , 2016 .

[3]  Min Jiang,et al.  Electrochemical microfluidic chip based on molecular imprinting technique applied for therapeutic drug monitoring. , 2017, Biosensors & bioelectronics.

[4]  Zeynep Altintas,et al.  Comparative investigations for adenovirus recognition and quantification: Plastic or natural antibodies? , 2015, Biosensors & bioelectronics.

[5]  Yi Li,et al.  Rapid preparation of molecularly imprinted polymers by microwave-assisted emulsion polymerization for the extraction of florfenicol in milk. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[6]  A. L. Ruela,et al.  Molecularly imprinted polymers as nicotine transdermal delivery systems , 2014 .

[7]  Shoufang Xu,et al.  Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. , 2011, Chemical Society reviews.

[8]  Haobo Pan,et al.  The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity. , 2017, Materials science & engineering. C, Materials for biological applications.

[9]  Hong Yang,et al.  Preparation of malathion MIP-SPE and its application in environmental analysis , 2015, Environmental Monitoring and Assessment.

[10]  P. Zahedi,et al.  Poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles containing 5-fluourouracil used in colon cancer therapy potentially , 2018, Polymers for Advanced Technologies.

[11]  Tao Zhu,et al.  Preparation of hybrid molecularly imprinted polymer with double-templates for rapid simultaneous purification of theophylline and chlorogenic acid in green tea. , 2016, Talanta.

[12]  Mirko Busato,et al.  Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25 , 2015, Journal of Nanobiotechnology.

[13]  Bo Mattiasson,et al.  Molecularly Imprinted Polymers in Biotechnology , 2015 .

[14]  Ronghua Liu,et al.  Preparation of Sialic Acid-Imprinted Fluorescent Conjugated Nanoparticles and Their Application for Targeted Cancer Cell Imaging. , 2017, ACS applied materials & interfaces.

[15]  Lei Ye,et al.  Molecularly imprinted polymers with multi-functionality , 2016, Analytical and Bioanalytical Chemistry.

[16]  Wei Chen,et al.  Molecularly imprinted polymers as receptor mimics for selective cell recognition. , 2018, Chemical Society reviews.

[17]  Carla Beatriz Grespan Bottoli,et al.  Molecularly imprinted polymers for bioanalytical sample preparation. , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[18]  Yan Zhang,et al.  Active targeting of tumors through conformational epitope imprinting. , 2015, Angewandte Chemie.

[19]  Umile Gianfranco Spizzirri,et al.  Molecular imprinting polymerization by Fenton reaction , 2010 .

[20]  I. Nicholls,et al.  Molecular imprinting science and technology: a survey of the literature for the years 2004–2011 , 2014, Journal of molecular recognition : JMR.

[21]  Hui Niu,et al.  One-pot synthesis of quantum dot-labeled hydrophilic molecularly imprinted polymer nanoparticles for direct optosensing of folic acid in real, undiluted biological samples. , 2016, Biosensors & bioelectronics.

[22]  Hiroyuki Koide,et al.  Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody. , 2010, Journal of the American Chemical Society.

[23]  Rosy,et al.  A melamine based molecularly imprinted sensor for the determination of 8-hydroxydeoxyguanosine in human urine. , 2017, Talanta.

[24]  Chien-Chong Hong,et al.  Handheld analyzer with on-chip molecularly-imprinted biosensors for electrical detection of propofol in plasma samples. , 2016, Biosensors & bioelectronics.

[25]  S. Ansari,et al.  Novel developments and trends of analytical methods for drug analysis in biological and environmental samples by molecularly imprinted polymers , 2017 .

[26]  Nicholas A Peppas,et al.  Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications. , 2016, Tissue engineering. Part B, Reviews.

[27]  Karsten Haupt,et al.  Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization , 2016 .

[28]  H. Hashemi-Moghaddam,et al.  Evaluation of molecularly imprinted polymer based on HER2 epitope for targeted drug delivery in ovarian cancer mouse model , 2017 .

[29]  Hui Niu,et al.  Direct and Highly Selective Drug Optosensing in Real, Undiluted Biological Samples with Quantum-Dot-Labeled Hydrophilic Molecularly Imprinted Polymer Microparticles. , 2016, ACS applied materials & interfaces.

[30]  Mercedes Villar-Navarro,et al.  Easy, fast and environmental friendly method for the simultaneous extraction of the 16 EPA PAHs using magnetic molecular imprinted polymers (mag-MIPs). , 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[31]  Yukari Nakamura,et al.  Preparation of molecularly imprinted polymers for strychnine by precipitation polymerization and multistep swelling and polymerization and their application for the selective extraction of strychnine from nux-vomica extract powder. , 2016, Journal of separation science.

[32]  Fei Liu,et al.  Bio-inspired virus imprinted polymer for prevention of viral infections. , 2017, Acta biomaterialia.

[33]  Jian Ouyang,et al.  Surface-enhanced Raman scattering imaging of cancer cells and tissues via sialic acid-imprinted nanotags. , 2015, Chemical communications.

[34]  H. Matsunaga,et al.  Molecularly imprinted polymer for caffeic acid by precipitation polymerization and its application to extraction of caffeic acid and chlorogenic acid from Eucommia ulmodies leaves. , 2016, Journal of pharmaceutical and biomedical analysis.

[35]  Hang Gong,et al.  A virus resonance light scattering sensor based on mussel-inspired molecularly imprinted polymers for high sensitive and high selective detection of Hepatitis A Virus. , 2017, Biosensors & bioelectronics.

[36]  John J. Evans,et al.  The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface , 2015, International journal of nanomedicine.

[37]  Nicole Jaffrezic-Renault,et al.  Voltammetric Sensor Based on a Double-Layered Molecularly Imprinted Polymer for Testosterone , 2018 .

[38]  Jianwei Bai,et al.  Synthesis and characterization of paclitaxel-imprinted microparticles for controlled release of an anticancer drug. , 2018, Materials science & engineering. C, Materials for biological applications.

[39]  Peter A. Lieberzeit,et al.  Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification. , 2013, Journal of materials chemistry. B.

[40]  Mingming Liu,et al.  A sol-gel derived pH-responsive bovine serum albumin molecularly imprinted poly(ionic liquids) on the surface of multiwall carbon nanotubes. , 2016, Analytica chimica acta.

[41]  Wei Qin,et al.  Preparation of hollow porous molecularly imprinted polymers and their applications to solid-phase extraction of triazines in soil samples , 2011 .

[42]  Dongdong Wang,et al.  A pH/glutathione double responsive drug delivery system using molecular imprint technique for drug loading , 2016 .

[43]  Adil Denizli,et al.  Molecularly Imprinted Polymer-Based Microfluidic Systems for Point-of-Care Applications , 2019, Micromachines.

[44]  Zhen Liu,et al.  Pattern Recognition of Cells via Multiplexed Imaging with Monosaccharide-Imprinted Quantum Dots. , 2017, Analytical chemistry.

[45]  Roger M. Leblanc,et al.  In vitro/in vivo study of novel anti-cancer, biodegradable cross-linked tannic acid for fabrication of 5-fluorouracil-targeting drug delivery nano-device based on a molecular imprinted polymer , 2016 .

[46]  Karsten Haupt,et al.  Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics , 2015, Advanced healthcare materials.

[47]  Rassoul Dinarvand,et al.  Paclitaxel molecularly imprinted polymer-PEG-folate nanoparticles for targeting anticancer delivery: Characterization and cellular cytotoxicity. , 2016, Materials science & engineering. C, Materials for biological applications.

[48]  Yi Sun,et al.  Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives. , 2017, Biosensors & bioelectronics.

[49]  Cristina Delerue-Matos,et al.  Molecular imprinted nanoelectrodes for ultra sensitive detection of ovarian cancer marker. , 2012, Biosensors & bioelectronics.

[50]  Ian A. Nicholls,et al.  The influence of a methyl substituent on molecularly imprinted polymer morphology and recognition – Acrylic acid versus methacrylic acid , 2017 .

[51]  Toshifumi Takeuchi,et al.  Beyond natural antibodies - a new generation of synthetic antibodies created by post-imprinting modification of molecularly imprinted polymers. , 2018, Chemical communications.

[52]  Shabi Abbas Zaidi,et al.  Latest trends in molecular imprinted polymer based drug delivery systems , 2016 .

[53]  Wenhua Ji,et al.  Preparation of hydrophilic molecularly imprinted polymers via bulk polymerization combined with hydrolysis of ester groups for selective recognition of iridoid glycosides , 2016, Analytical and Bioanalytical Chemistry.

[54]  G. Ozin,et al.  Controlling morphology and porosity to improve performance of molecularly imprinted sol-gel silica. , 2014, Chemical Society reviews.

[55]  F. Granados-Chinchilla,et al.  Tetracyclines in Food and Feedingstuffs: From Regulation to Analytical Methods, Bacterial Resistance, and Environmental and Health Implications , 2017, Journal of analytical methods in chemistry.

[56]  Peter A. Lieberzeit,et al.  Molecularly imprinted polymer nanoparticles in chemical sensing – Synthesis, characterisation and application , 2015 .

[57]  Yueqi Liu,et al.  Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization. , 2010, Talanta.

[58]  N. Razavi,et al.  Application of molecularly-imprinted polymers in solid-phase microextraction techniques , 2015 .

[59]  Judith Wackerlig,et al.  Applications of Molecularly Imprinted Polymer Nanoparticles and Their Advances toward Industrial Use: A Review. , 2016, Analytical chemistry.

[60]  Enrico Drioli,et al.  Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes , 2014, Sensors.

[61]  Cristina Delerue-Matos,et al.  Breast cancer biomarker (HER2-ECD) detection using a molecularly imprinted electrochemical sensor , 2018, Sensors and Actuators B: Chemical.

[62]  Xing Li,et al.  A cost-effective sandwich electrochemiluminescence immunosensor for ultrasensitive detection of HIV-1 antibody using magnetic molecularly imprinted polymers as capture probes. , 2014, Biosensors & bioelectronics.

[63]  Hui Niu,et al.  Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples. , 2015, Biosensors & bioelectronics.

[64]  Jun-Jie Zhu,et al.  Targeting and Imaging of Cancer Cells via Monosaccharide-Imprinted Fluorescent Nanoparticles , 2016, Scientific Reports.

[65]  Yan Zhang,et al.  Preparation of molecularly imprinted polymers for vanillin via reversible addition‐fragmentation chain transfer suspension polymerization , 2013 .

[66]  Elena Piletska,et al.  Molecularly imprinted polymer cartridges coupled to high performance liquid chromatography (HPLC-UV) for simple and rapid analysis of fenthion in olive oil. , 2014, Talanta.

[67]  Xiaqing Wu,et al.  Molecular imprinting: perspectives and applications. , 2016, Chemical Society reviews.

[68]  Xuguang Liu,et al.  Temperature and Magnetism Bi-responsive Molecularly Imprinted Polymers: Preparation, Adsorption Mechanism And , 2016 .

[69]  Zahra Ramezani,et al.  Facile synthesis of magnetic molecularly imprinted polymer: Perphenazine template and its application in urine and plasma analysis. , 2016, Journal of chromatography. A.

[70]  Anthony P F Turner,et al.  Molecularly-imprinted polymer sensors: realising their potential. , 2016, Biosensors & bioelectronics.

[71]  Feiyun Cui,et al.  Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases , 2020, Sensors.

[72]  Cristina Delerue-Matos,et al.  Molecularly imprinted electrochemical sensor for the point-of-care detection of a breast cancer biomarker (CA 15-3) , 2018 .

[73]  Adil Denizli,et al.  Molecularly imprinted polymer based quartz crystal microbalance sensor system for sensitive and label-free detection of synthetic cannabinoids in urine. , 2018, Biosensors & bioelectronics.

[74]  Giuseppe Vasapollo,et al.  Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples , 2015, International journal of molecular sciences.

[75]  Yingchun Li,et al.  Preparation of molecularly imprinted polymer with double templates for rapid simultaneous determination of melamine and dicyandiamide in dairy products. , 2015, Talanta.

[76]  Giuseppe Vasapollo,et al.  Molecularly Imprinted Polymers: Present and Future Prospective , 2011, International journal of molecular sciences.

[77]  Shengrong Shen,et al.  State-of-the-art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review. , 2016, Journal of separation science.

[78]  Xinglin Li,et al.  Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods. , 2017, Chemical communications.

[79]  Ali Mohammadi,et al.  Synthesis of new molecularly imprinted polymer via reversible addition fragmentation transfer polymerization as a drug delivery system , 2018 .

[80]  Liang Xu,et al.  Synthesis of multirecognition magnetic molecularly imprinted polymer by atom transfer radical polymerization and its application in magnetic solid-phase extraction , 2017, Analytical and Bioanalytical Chemistry.

[81]  Youwei Zhang,et al.  Synthesis of polyacrylonitrile nanoparticles at high monomer concentrations by AIBN-initiated semi-continuous emulsion polymerization method , 2015 .

[82]  Xueying Tu,et al.  Molecularly Imprinted Plasmonic Substrates for Specific and Ultrasensitive Immunoassay of Trace Glycoproteins in Biological Samples. , 2017, ACS applied materials & interfaces.

[83]  Karsten Haupt,et al.  Molecularly Imprinted Polymer Coated Quantum Dots for Multiplexed Cell Targeting and Imaging. , 2016, Angewandte Chemie.

[84]  Ai-Hong Peng,et al.  Biomimetic ELISA detection of malachite green based on magnetic molecularly imprinted polymers. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[85]  David Fenyö,et al.  Optimizing selection of large animals for antibody production by screening immune response to standard vaccines. , 2016, Journal of immunological methods.

[86]  Rijun Gui,et al.  Recent advances and future prospects in molecularly imprinted polymers-based electrochemical biosensors. , 2018, Biosensors & bioelectronics.

[87]  Fabio Benedetti,et al.  Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma. , 2016, Biosensors & bioelectronics.

[88]  Elena Piletska,et al.  Development of molecularly imprinted polymers specific for blood antigens for application in antibody-free blood typing. , 2017, Chemical communications.

[89]  K. Tikoo,et al.  Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: potential role of tannins in cancer chemotherapy. , 2011, Toxicology and applied pharmacology.

[90]  Gizem Ertürk,et al.  Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples , 2016 .