Heart Rate Variability based Classification of Normal and Hypertension Cases by Linear-nonlinear Method

The aim of this study is to analyse and compare the heart rate variability (HRV) of normal and hypertension cases using time domain, frequency domain, and nonlinear methods. For short term HRV analysis, a five-minute electrocardiogram (ECG) of 57 normal and 56 hypertension subjects were recorded with prior verification of their clinical status by a cardiologist. Most time domain features of hypertension cases have clearly reduced values over normal subjects, frequency domain features, like power in different spectral bands, also have the distinguishable decreased values, whereas sympathovagal balance has clear edge over hypertension cases than normal cases. Nonlinear parameters of Poincare plot, approximate entropy and sample entropy, have higher values in normal cases when compared with hypertension cases. Support vector machine-based binary system classifies these two classes with 100 per cent accuracy and 100 per cent sensitivity when all time domain, frequency domain, and nonlinear features were used. It may work as a better predictor for in patients with hypertension. Science Journal, Vol. 64, No. 6, November 2014, pp.542-548, DOI:http://dx.doi.org/10.14429/dsj.64.7867

[1]  Juan F. Ramirez-Villegas,et al.  Heart Rate Variability Dynamics for the Prognosis of Cardiovascular Risk , 2011, PloS one.

[2]  A. Pichon,et al.  Heart rate variability and depressed mood in physical education students: A longitudinal study , 2010, Autonomic Neuroscience.

[3]  Vinod Kumar,et al.  Prediction of liver cirrhosis based on multiresolution texture descriptors from B-mode ultrasound , 2013 .

[4]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .

[5]  Dimitrios I. Fotiadis,et al.  Automatic arrhythmia detection based on time and time-frequency analysis of heart rate variability , 2004, Comput. Methods Programs Biomed..

[6]  Vinod Kumar,et al.  A comparative study on spectral parameters of HRV in yogic and non-yogic practitioners , 2010, Int. J. Medical Eng. Informatics.

[7]  S M Pincus,et al.  Approximate entropy as a measure of system complexity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Jitendra Virmani,et al.  Prediction of cirrhosis from liver ultrasound B-mode images based on Laws' masks analysis , 2011, 2011 International Conference on Image Information Processing.

[9]  Jitendra Virmani,et al.  SVM-Based Characterization of Liver Ultrasound Images Using Wavelet Packet Texture Descriptors , 2013, Journal of Digital Imaging.

[10]  J. Fleiss,et al.  Frequency Domain Measures of Heart Period Variability and Mortality After Myocardial Infarction , 1992, Circulation.

[11]  T. Ishimitsu,et al.  Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers. , 1999, Hypertension.

[12]  Christian Schindler,et al.  Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors: results of the SAPALDIA study. , 2006, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[13]  Yon-Kyu Park,et al.  A study on development of multi-parametric measure of heart rate variability diagnosing cardiovascular disease , 2007 .

[14]  Vinod Kumar,et al.  A comparative study of computer-aided classification systems for focal hepatic lesions from B-mode ultrasound , 2013, Journal of medical engineering & technology.

[15]  Duanping Liao,et al.  Hypertension, Blood Pressure, and Heart Rate Variability The Atherosclerosis Risk in Communities (ARIC) Study , 2003 .

[16]  Jagmeet P. Singh,et al.  Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). , 2000, The American journal of cardiology.

[17]  T. Pearson Alcohol and heart disease. , 1996, Circulation.

[18]  M. G. Poddar,et al.  Linear-nonlinear heart rate variability analysis and SVM based classification of normal and hypertensive subjects , 2013 .

[19]  Keun Ho Ryu,et al.  Mining Biosignal Data: Coronary Artery Disease Diagnosis Using Linear and Nonlinear Features of HRV , 2007, PAKDD Workshops.

[20]  George Manis,et al.  Heartbeat Time Series Classification With Support Vector Machines , 2009, IEEE Transactions on Information Technology in Biomedicine.

[21]  H Helenius,et al.  Reduced heart rate variability in hypertension: associations with lifestyle factors and plasma renin activity , 2003, Journal of Human Hypertension.

[22]  Chih-Jen Lin,et al.  LIBSVM: A library for support vector machines , 2011, TIST.

[23]  Jitendra Virmani,et al.  Characterization of Primary and Secondary Malignant Liver Lesions from B-Mode Ultrasound , 2013, Journal of Digital Imaging.

[24]  John T. Cacioppo,et al.  Heart Rate Variability: Stress and Psychiatric Conditions , 2007 .

[25]  Seyed Kamaledin Setarehdan,et al.  Support vector machine-based arrhythmia classification using reduced features of heart rate variability signal , 2008, Artif. Intell. Medicine.

[26]  S. C. Saxena,et al.  Effects of RR segment duration on HRV spectrum estimation. , 2004, Physiological measurement.

[27]  G. Berntson,et al.  Heart Rate Variability Predicts Cell Death and Inflammatory Responses to Global Cerebral Ischemia , 2012, Front. Physio..

[28]  Vinod Kumar,et al.  Ageing effects on HRV dynamics: a comparative study with FFT and AR models , 2013 .

[29]  Jitendra Virmani,et al.  SVM-based characterisation of liver cirrhosis by singular value decomposition of GLCM matrix , 2013, Int. J. Artif. Intell. Soft Comput..

[30]  J. Richman,et al.  Physiological time-series analysis using approximate entropy and sample entropy. , 2000, American journal of physiology. Heart and circulatory physiology.