Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor Published, JLR Papers in Press, August 1, 2004. DOI 10.1194/jlr.M400257-JLR200
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Liang Chen | P. Nambi | Ponnal Nambi | E. Quinet | D. Savio | Anita R Halpern | C. Miller | Elaine M Quinet | Dawn A Savio | Liang Chen | Christopher P Miller | Dawn A. Savio
[1] J. Gustafsson,et al. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. , 2001, The Journal of clinical investigation.
[2] P. Edwards,et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[3] D. Mangelsdorf,et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. , 2000, Science.
[4] L. Moore,et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. , 2001, Journal of medicinal chemistry.
[5] T. Willson,et al. Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages* , 2001, The Journal of Biological Chemistry.
[6] D. Mangelsdorf,et al. Role of LXRs in control of lipogenesis. , 2000, Genes & development.
[7] J. Piette,et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 , 1999, Nature Genetics.
[8] S. Kliewer,et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[9] C. Sensen,et al. Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux , 1999, The Lancet.
[10] J. Gustafsson,et al. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[11] Suzhen Li,et al. Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism , 2002 .
[12] Aldons J. Lusis,et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[13] R. Lawn,et al. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. , 2000, Biochemical and biophysical research communications.
[14] D. Mangelsdorf,et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[15] A. Tall,et al. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. , 2000, The Journal of clinical investigation.
[16] S. Liao,et al. Hypolipidemic effects of selective liver X receptor alpha agonists , 2001, Steroids.
[17] O. Francone,et al. Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages , 2002, Arteriosclerosis, thrombosis, and vascular biology.
[18] A. Tall,et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. , 2000, The Journal of biological chemistry.
[19] R. Hammer,et al. Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.
[20] M. Brown,et al. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[21] W. Fung-Leung,et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[22] D. McDonnell,et al. Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators. , 2002, Recent progress in hormone research.
[23] R. Hiipakka,et al. Selective activation of liver X receptor alpha by 6α-hydroxy bile acids and analogs , 2000, Steroids.
[24] H. Hobbs,et al. Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* , 2002, The Journal of Biological Chemistry.
[25] R. Hiipakka,et al. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[26] T. Langmann,et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease , 1999, Nature Genetics.
[27] D. Mangelsdorf,et al. Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages , 2000, The Journal of Biological Chemistry.
[28] R. Walczak,et al. Autoregulation of the Human Liver X Receptor α Promoter , 2001, Molecular and Cellular Biology.
[29] T. Willson,et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[30] A. Zwinderman,et al. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study , 2002, The Lancet.
[31] N. Grishin,et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. , 2000, Science.
[32] C. Sensen,et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency , 1999, Nature Genetics.
[33] Mary K. Bennett,et al. Sterol Regulation of Fatty Acid Synthase Promoter , 1995, The Journal of Biological Chemistry.
[34] Jean-Marc A. Lobaccaro,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .
[35] Hitoshi Shimano,et al. Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter , 2001, Molecular and Cellular Biology.
[36] Peter Tontonoz,et al. Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors* , 2002, The Journal of Biological Chemistry.
[37] Shutsung Liao,et al. Cholestenoic Acid Is a Naturally Occurring Ligand for Liver X Receptor α* * This work was supported by NIH grants. , 2000, Endocrinology.
[38] D. Mangelsdorf,et al. An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.
[39] Timothy M Willson,et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. , 2002, Journal of medicinal chemistry.
[40] Timothy M. Willson,et al. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway* , 1997, The Journal of Biological Chemistry.
[41] K. Umesono,et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. , 1995, Genes & development.
[42] B. Spiegelman,et al. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. , 1996, Genes & development.
[43] R. Hammer,et al. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. , 1996, The Journal of clinical investigation.