Central Contributions to Contractions Evoked by Tetanic Neuromuscular Electrical Stimulation

Tetanic electrical stimulation applied over human muscle or peripheral nerve generates contractions by depolarizing motor axons beneath the stimulating electrodes. However, the simultaneous depolarization of sensory axons can also contribute to the contractions by the synaptic recruitment of spinal motoneurons. Maximizing this central contribution may be beneficial for reducing muscle atrophy or restoring movement for persons with movement disorders.

[1]  P. Cavallari,et al.  Motor neuron 'bistability'. A pathogenetic mechanism for cramps and myokymia. , 1994, Brain : a journal of neurology.

[2]  A. Lang,et al.  Motoneuron activation by low intensity tetanic stimulation of muscle afferents in man. , 1967, Experimental neurology.

[3]  Jaynie F. Yang,et al.  Role of motoneurons in the generation of muscle spasms after spinal cord injury. , 2004, Brain : a journal of neurology.

[4]  M. Gorassini,et al.  Persistent inward currents in motoneuron dendrites: Implications for motor output , 2005, Muscle & nerve.

[5]  J. Erlanger,et al.  A COMPARISON OF THE CHARACTERISTICS OF AXONS THROUGH THEIR INDIVIDUAL ELECTRICAL RESPONSES , 1933 .

[6]  D. Burke,et al.  Sustained contractions produced by plateau‐like behaviour in human motoneurones , 2002, The Journal of physiology.

[7]  M. Akai,et al.  Sustained muscle contractions maintained by autonomous neuronal activity within the human spinal cord. , 2003, Journal of neurophysiology.

[8]  F. Buchthal,et al.  Contraction times of reflexly activated motor units and excitability cycle of the H-reflex. , 1976, Progress in brain research.

[9]  S C Gandevia,et al.  Large Involuntary Forces Consistent with Plateau-Like Behavior of Human Motoneurons , 2001, The Journal of Neuroscience.

[10]  G. Somjen,et al.  Excitability and inhibitability of motoneurons of different sizes. , 1965, Journal of neurophysiology.

[11]  P. Jacobs,et al.  Exercise Recommendations for Individuals with Spinal Cord Injury , 2004, Sports medicine.

[12]  D. F. Collins,et al.  Turning on the central contribution to contractions evoked by neuromuscular electrical stimulation. , 2007, Journal of applied physiology.

[13]  Jaynie F. Yang,et al.  Self-sustained firing of human motor units , 1998, Neuroscience Letters.

[14]  R. Gorman,et al.  Forces consistent with plateau-like behaviour of spinal neurons evoked in patients with spinal cord injuries. , 2003, Brain : a journal of neurology.

[15]  D. P. Lloyd.  POST-TETANIC POTENTIATION OF RESPONSE IN MONOSYNAPTIC REFLEX PATHWAYS OF THE SPINAL CORD , 1949, The Journal of general physiology.

[16]  Jaynie F. Yang,et al.  Intrinsic activation of human motoneurons: possible contribution to motor unit excitation. , 2002, Journal of neurophysiology.

[17]  J. Hounsgaard,et al.  Metabotropic Modulation of Motoneurons by Scratch-Like Spinal Network Activity , 2003, The Journal of Neuroscience.

[18]  Thomas Sinkjaer,et al.  Motor cortex excitability following repetitive electrical stimulation of the common peroneal nerve depends on the voluntary drive , 2005, Experimental Brain Research.

[19]  R. Shields,et al.  Muscular, skeletal, and neural adaptations following spinal cord injury. , 2002, The Journal of orthopaedic and sports physical therapy.

[20]  D. F. Collins,et al.  Contribution of M-waves and H-reflexes to contractions evoked by tetanic nerve stimulation in humans. , 2006, Journal of neurophysiology.

[21]  M. Illert,et al.  On the mechanism of the post-activation depression of the H-reflex in human subjects , 1996, Experimental Brain Research.

[22]  Chris M Gregory,et al.  Recruitment patterns in human skeletal muscle during electrical stimulation. , 2005, Physical therapy.

[23]  D. F. Collins,et al.  Wide-pulse-width, high-frequency neuromuscular stimulation: implications for functional electrical stimulation. , 2006, Journal of applied physiology.

[24]  R. Mark,et al.  Differential sensitivity of motor and sensory fibres in human ulnar nerve , 1973, Journal of neurology, neurosurgery, and psychiatry.

[25]  R. Burke.  Motor Units: Anatomy, Physiology, and Functional Organization , 1981 .

[26]  R. Shields,et al.  Low frequency depression of H-reflexes in humans with acute and chronic spinal-cord injury , 2000, Experimental Brain Research.

[27]  D Burke,et al.  Discharge pattern of single motor units in the tonic vibration reflex of human triceps surae. , 1976, Journal of neurology, neurosurgery, and psychiatry.

[28]  X. Li,et al.  Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats. , 2006, Journal of neurophysiology.

[29]  David Burke,et al.  Recent evidence for plateau potentials in human motoneurones. , 2002, Advances in experimental medicine and biology.