Adult thyroid cancer after head and neck irradiation in infancy and childhood.

We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...

[1]  B. Modan,et al.  Radiation-induced head and neck tumours. , 1974, Lancet.

[2]  L. Degroot,et al.  Thyroid carcinoma and radiation. A Chicago endemic. , 1973, JAMA.

[3]  R. Nishiyama,et al.  Childhood thyroid carcinoma. , 1971, Archives of surgery.

[4]  G. Weir.  Thyroid carcinoma after irradiation. , 1970, Archives of surgery.

[5]  C. Platz,et al.  Thyroid carcinoma after irradiation. Characteristics and treatment. , 1970, Archives of surgery.

[6]  M. Yonekura,et al.  Study of intraglandular dissemination of thyroid cancer , 1969, Cancer.

[7]  G. Burke,et al.  Neoplasms in persons treated with x rays in infancy for thymic enlargement. A report of the third follow-up survey. , 1967, Journal of the National Cancer Institute.

[8]  L. Hempelmann,et al.  Neoplasms following irradiation of the head. , 1966, Cancer research.

[9]  L. Woolner,et al.  CARCINOMA OF THE THYROID IN CHILDREN. , 1963, American journal of surgery.

[10]  E. White,et al.  Thyroid carcinoma. Classification, intraglandular dissemination, and clinicopathological study based upon whole organ sections of 80 glands , 1963, Cancer.

[11]  T. Sterling,et al.  Neoplasia following therapeutic irradiation for benign conditions in childhood. , 1960, Radiology.

[12]  E. H. Wilson,et al.  The role of x-ray therapy to the neck region in the production of thyroid cancer in young people. A report of thirty-seven cases. , 1960, Archives of internal medicine.

[13]  R. Powell,et al.  Carcinoma of the thyroid in children after x-ray therapy in early childhood. , 1959, Journal of the American Medical Association.

[14]  T. Winship.  Carcinoma of the thyroid in childhood. , 1956, Pediatrics.

[15]  R. Jepson,et al.  Thyroid Neoplasms following Irradiation* , 1958, British medical journal.

[16]  H. Charache.  Mixed tumor of the submaxillary gland, treated by surgery and radiation, followed eighteen years later by carcinoma of the thyroid. , 1956, Jornal de Pediatria.

[17]  D. Slaughter,et al.  Thyroid cancer in childhood and adolescence. , 1956, The Journal of clinical endocrinology and metabolism.

[18]  D E CLARK,et al.  Association of irradiation with cancer of the thyroid in children and adolescents. , 1955, Journal of the American Medical Association.

[19]  L. Fuller,et al.  Neoplasia in children treated with X-rays in infancy for thymic enlargement. , 1955, Radiology.

[20]  W. S. Morgan,et al.  Cancer of the thyroid. , 1954, The Journal of clinical endocrinology and metabolism.

[21]  B. Duffy,et al.  Cancer of the thyroid in children: a report of 28 cases. , 1950, The Journal of clinical endocrinology and metabolism.

[22]  B. Mcswain,et al.  Malignant tumors of the thyroid gland. , 1948, Surgery.