Global synchronization of delay-coupled genetic oscillators

This paper investigates the global exponential synchronization of delay-coupled identical genetic oscillator. By constructing appropriate Lyapunov functional and using the linear matrix inequality (LMI) approach, a series of sufficient criteria, which are very easy to verify, are obtained. It is shown that these criteria improve and extend the earlier works. Finally, a population of genetic oscillators based on the Goodwin model is adopted as a numerical example to demonstrate the effectiveness of our theoretical results.

[1]  K. Aihara,et al.  Stability of genetic regulatory networks with time delay , 2002 .

[2]  J. Collins,et al.  Construction of a genetic toggle switch in Escherichia coli , 2000, Nature.

[3]  B. Goodwin Oscillatory behavior in enzymatic control processes. , 1965, Advances in enzyme regulation.

[4]  Gary D Bader,et al.  Global Mapping of the Yeast Genetic Interaction Network , 2004, Science.

[5]  S. Yamaguchi,et al.  Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus , 2003, Science.

[6]  S. Bernard,et al.  Spontaneous synchronization of coupled circadian oscillators. , 2005, Biophysical journal.

[7]  A. Winfree The geometry of biological time , 1991 .

[8]  Jinde Cao,et al.  Robust stability of genetic regulatory networks with distributed delay , 2008, Cognitive Neurodynamics.

[9]  Jinde Cao,et al.  Exponential Stability of Discrete-Time Genetic Regulatory Networks With Delays , 2008, IEEE Transactions on Neural Networks.

[10]  E. Yaz Linear Matrix Inequalities In System And Control Theory , 1998, Proceedings of the IEEE.

[11]  Nancy Kopell,et al.  Synchrony in a Population of Hysteresis-Based Genetic Oscillators , 2004, SIAM J. Appl. Math..

[12]  A. Goldbeter A model for circadian oscillations in the Drosophila period protein (PER) , 1995, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[13]  A. Goldbeter,et al.  Biochemical Oscillations And Cellular Rhythms: Contents , 1996 .

[14]  Stephen P. Boyd,et al.  Linear Matrix Inequalities in Systems and Control Theory , 1994 .

[15]  Mads Kaern,et al.  The engineering of gene regulatory networks. , 2003, Annual review of biomedical engineering.

[16]  P. Ruoff,et al.  The Goodwin model: simulating the effect of light pulses on the circadian sporulation rhythm of Neurospora crassa. , 2001, Journal of theoretical biology.

[17]  Chai Wah Wu,et al.  Synchronization in arrays of coupled nonlinear systems with delay and nonreciprocal time-varying coupling , 2005, IEEE Transactions on Circuits and Systems II: Express Briefs.

[18]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[19]  Kazuyuki Aihara,et al.  Stability of Genetic Networks With SUM Regulatory Logic: Lur'e System and LMI Approach , 2006, IEEE Transactions on Circuits and Systems I: Regular Papers.

[20]  Jinde Cao,et al.  Genetic oscillation deduced from Hopf bifurcation in a genetic regulatory network with delays. , 2008, Mathematical biosciences.

[21]  Jinde Cao,et al.  Asymptotic and robust stability of genetic regulatory networks with time-varying delays , 2008, Neurocomputing.

[22]  K. Aihara,et al.  Synchronization of coupled nonidentical genetic oscillators , 2006, Physical biology.

[23]  M. Elowitz,et al.  Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Luonan Chen,et al.  Synchronizing Genetic Oscillators by Signaling Molecules , 2005, Journal of biological rhythms.

[25]  M. Elowitz,et al.  A synthetic oscillatory network of transcriptional regulators , 2000, Nature.

[26]  Tianping Chen,et al.  Synchronization of coupled connected neural networks with delays , 2004, IEEE Transactions on Circuits and Systems I: Regular Papers.