Prognosis and Biology in Esthesioneuroblastoma: the Emerging Role of Hyams Grading System

Esthesioneuroblastoma is a sinonasal tumor with distinct clinicopathologic features, multiple facets, and a spectrum of behavior. Characterization of this disease is challenging, and clinically, several staging systems have been used with no consensus on a single scheme. Recently, the Hyams histological grading system has emerged as a promising prognostication tool that offers an added value to stage. This review addresses prognosis and biology in esthesioneuroblastoma. More specifically, we sought to present a critical appraisal on the value of each of these stratification systems, stage vs. grade, in identifying risk groups and guiding management.

[1]  T. Calcaterra,et al.  Esthesioneuroblastoma: The UCLA experience 1970–1990 , 1992, The Laryngoscope.

[2]  F. Ottaviani,et al.  Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924. , 1997, Anticancer research.

[3]  C. Kim,et al.  Expression of Bcl-2 in Olfactory Neuroblastoma and its Association with Chemotherapy and Survival , 2008, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[4]  J. Mchugh,et al.  Esthesioneuroblastoma , 2001, Head & neck.

[5]  K. Ohshima,et al.  Clincopathological analysis of olfactory neuroblastoma , 2012, Brain Tumor Pathology.

[6]  M. Citardi,et al.  Esthesioneuroblastoma: 25-year experience at a single institution , 2008, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  M. Kupferman,et al.  Head and Neck Pathology: Poster#183 PROGNOSTIC UTILITY OF HYAMS HISTOLOGICAL GRADING AND KADISH-MORITA STAGING SYSTEMS FOR ESTHESIONEUROBLASTOMA OUTCOMES , 2014 .

[8]  E. Hanna,et al.  Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers , 2013, Expert review of anticancer therapy.

[9]  Anurag K. Singh,et al.  Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database , 2011, Radiation oncology.

[10]  W. Lawson,et al.  Esthesioneuroblastoma: Surgical treatment without radiation , 1990, The Laryngoscope.

[11]  K. Olsen,et al.  Esthesioneuroblastoma: prognosis and management. , 1993, Neurosurgery.

[12]  M. Berger,et al.  The prognostic implications of Hyam’s subtype for patients with Kadish stage C esthesioneuroblastoma , 2013, Journal of Clinical Neuroscience.

[13]  J. Mchugh,et al.  Esthesioneuroblastoma: updating histologic grading as it relates to prognosis. , 2014, The Annals of otology, rhinology, and laryngology.

[14]  Nicholas B. Levine,et al.  Optimization of long‐term outcomes for patients with esthesioneuroblastoma , 2014, Head & neck.

[15]  S. Menon,et al.  Sinonasal malignancies with neuroendocrine differentiation: case series and review of literature. , 2010, Indian journal of pathology & microbiology.

[16]  J. Buckner,et al.  Long-Term Outcome of Esthesioneuroblastoma: Hyams Grade Predicts Patient Survival , 2012, Journal of Neurological Surgery—Part B.

[17]  H. Frierson,et al.  Sinonasal Undifferentiated Carcinoma: An Aggressive Neoplasm Derived from Schneiderian Epithelium and Distinct from Olfactory Neuroblastoma , 1986, The American journal of surgical pathology.

[18]  I. Barani,et al.  Posttreatment prognosis of patients with esthesioneuroblastoma. , 2010, Journal of neurosurgery.

[19]  T. Rodt,et al.  Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma , 2008, Journal of Neuro-Oncology.

[20]  C. C. Wang,et al.  Olfactory neuroblastoma—A clinical analysis of 17 cases , 1976, Cancer.

[21]  J. Batsakis,et al.  Tumors of the upper respiratory tract and ear , 1988 .

[22]  G. Fuller,et al.  Misdiagnosis of olfactory neuroblastoma. , 2002, Neurosurgical focus.

[23]  Steve,et al.  Posttreatment prognosis of patients with esthesioneuroblastoma Clinical article , 2022 .

[24]  G. Malouf,et al.  Low- and high-grade esthesioneuroblastomas display a distinct natural history and outcome. , 2013, European journal of cancer.

[25]  L. Berger.  L'esthesioneuroepitheliomae olfactif , 1924 .

[26]  R. Gilbert,et al.  Esthesioneuroblastoma: The Princess Margaret Hospital experience , 2008, Head & neck.

[27]  T. Calcaterra,et al.  Esthesioneuroblastoma: a meta-analysis and review. , 2001, The Lancet. Oncology.

[28]  D. Kutler,et al.  Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors. , 2007, Archives of otolaryngology--head & neck surgery.