The neuroscience of human intelligence differences

Neuroscience is contributing to an understanding of the biological bases of human intelligence differences. This work is principally being conducted along two empirical fronts: genetics — quantitative and molecular — and brain imaging. Quantitative genetic studies have established that there are additive genetic contributions to different aspects of cognitive ability — especially general intelligence — and how they change through the lifespan. Molecular genetic studies have yet to identify reliably reproducible contributions from individual genes. Structural and functional brain-imaging studies have identified differences in brain pathways, especially parieto-frontal pathways, that contribute to intelligence differences. There is also evidence that brain efficiency correlates positively with intelligence.

[1]  F. T.,et al.  Head Growth in Students at the University of Cambridge , 1889, Nature.

[2]  Wm. R. Wright General Intelligence, Objectively Determined and Measured. , 1905 .

[3]  E. A. Spitzka A study of the brains of six eminent scientists and scholars belonging to the Amerian anthropometric society, together with a description of the skull of Professor E.D. Cope , 1907 .

[4]  E. Boring Intelligence as the Tests Test It. , 1961 .

[5]  R. Wilson Synchronies in mental development: an epigenetic perspective. , 1978, Science.

[6]  T. Bouchard,et al.  Familial studies of intelligence: a review. , 1981, Science.

[7]  H. Birx,et al.  The Mismeasure of Man , 1981 .

[8]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[9]  M. Buchsbaum,et al.  Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography , 1988 .

[10]  Lloyd G. Humphreys,et al.  Intelligence Measurement Theory And Public Policy Proceedings Of A Symposium In Honor Of Lloyd G Humphreys , 1989 .

[11]  Frank J. Bernieri,et al.  Growing up and growing apart: a developmental meta-analysis of twin studies. , 1990, Psychological bulletin.

[12]  R. Plomin Behavioral genetics. , 1991, Research publications - Association for Research in Nervous and Mental Disease.

[13]  J. Ehrhardt,et al.  Intelligence and brain structure in normal individuals. , 1993, The American journal of psychiatry.

[14]  A. Caspi,et al.  The natural history of change in intellectual performance: who changes? How much? Is it meaningful? , 1993, Journal of child psychology and psychiatry, and allied disciplines.

[15]  Robert Plomin,et al.  Nature, Nurture, and Psychology , 1993 .

[16]  Thomas J. Bouchard,et al.  Behavioral genetics of cognitive ability: A life-span perspective. , 1993 .

[17]  N. Pedersen,et al.  Heritability of cognitive abilities in adult twins: Comparison of Minnesota and Swedish data , 1995, Behavior genetics.

[18]  E. Oord,et al.  An examination of genotype-environment interactions for academic achievement in an U.S. national , 1997 .

[19]  Nancy C. Andreasen,et al.  Intelligence and regional brain volumes in normal controls , 1997 .

[20]  L. Gottfredson Mainstream science on intelligence: An editorial with 52 signatories, history, and bibliography , 1997 .

[21]  L. Gottfredson Why g matters: The complexity of everyday life , 1997 .

[22]  G. Mcclearn,et al.  The Genetic and Environmental Relationship Between General and Specific Cognitive Abilities in Twins Age 80 and Older , 1998 .

[23]  Michael C. Pyryt Human cognitive abilities: A survey of factor analytic studies , 1998 .

[24]  G. D. de Courten-Myers The human cerebral cortex: gender differences in structure and function. , 1999, Journal of neuropathology and experimental neurology.

[25]  A. Toga,et al.  In vivo evidence for post-adolescent brain maturation in frontal and striatal regions , 1999, Nature Neuroscience.

[26]  Robert A. Zimmerman,et al.  Proton magnetic resonance spectroscopy , 1999, Critical reviews in neurosurgery : CR.

[27]  Gabrielle M. de Courten-Myers,et al.  The human cerebral cortex: gender differences in structure and function. , 1999 .

[28]  R. Sternberg,et al.  Handbook of Intelligence , 2000 .

[29]  Ian J. Deary,et al.  Looking down on human intelligence , 2000 .

[30]  Ian J. Deary,et al.  The Stability of Individual Differences in Mental Ability from Childhood to Old Age: Follow-up of the 1932 Scottish Mental Survey , 2000 .

[31]  David N. Kennedy,et al.  A Twin MRI Study of Size Variations in the Human Brain , 2000, Journal of Cognitive Neuroscience.

[32]  David F. Lohman,et al.  Handbook of Intelligence: Complex Information Processing and Intelligence , 2000 .

[33]  Book Reviews,et al.  Looking Down on Human Intelligence: From Psychometrics to the Brain , 2001 .

[34]  D. Posthuma,et al.  Perceptual Speed and IQ Are Associated Through Common Genetic Factors , 2001, Behavior genetics.

[35]  Tyrone D. Cannon,et al.  Genetic influences on brain structure , 2001, Nature Neuroscience.

[36]  K. Schoonover-Shoffner,et al.  Sex matters , 2001, Nature Medicine.

[37]  R. Kahn,et al.  The association between brain volume and intelligence is of genetic origin , 2002, Nature Neuroscience.

[38]  Karen J. Ferguson,et al.  Intracranial capacity and brain volumes are associated with cognition in healthy elderly men , 2002, Neurology.

[39]  P. Vernon,et al.  Application of Hierarchical Genetic Models to Raven and WAIS Subtests: A Dutch Twin Study , 2002, Behavior genetics.

[40]  D I Boomsma,et al.  Genetic and Environmental Influences on the Development of Intelligence , 2002, Behavior genetics.

[41]  R. Cabeza Hemispheric asymmetry reduction in older adults: the HAROLD model. , 2002, Psychology and aging.

[42]  Dorret I Boomsma,et al.  Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed. , 2003, Twin research : the official journal of the International Society for Twin Studies.

[43]  R. Plomin,et al.  Phenotypic "g" Early in Life: On the Etiology of General Cognitive Ability in a Large Population Sample of Twin Children Aged 2-4 Years. , 2003 .

[44]  M. Petrides,et al.  Cognitive Strategies Dependent on the Hippocampus and Caudate Nucleus in Human Navigation: Variability and Change with Practice , 2003, The Journal of Neuroscience.

[45]  I. Gottesman,et al.  Socioeconomic Status Modifies Heritability of IQ in Young Children , 2003, Psychological science.

[46]  Roger T Staff,et al.  Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932. , 2003, Psychology and aging.

[47]  R. Kahn,et al.  Genetic Correlations Between Brain Volumes and the WAIS-III Dimensions of Verbal Comprehension, Working Memory, Perceptual Organization, and Processing Speed , 2003, Twin Research.

[48]  H. Heffner,et al.  The Evolution of Human , 2004 .

[49]  T. Salthouse Localizing age-related individual differences in a hierarchical structure. , 2004, Intelligence.

[50]  O. Sporns,et al.  Organization, development and function of complex brain networks , 2004, Trends in Cognitive Sciences.

[51]  Eileen Luders,et al.  Gender differences in cortical complexity , 2004, Nature Neuroscience.

[52]  Mark D'Esposito,et al.  Dissociating Age-related Changes in Cognitive Strategy and Neural Efficiency Using Event- related fMRI , 2005, Cortex.

[53]  Thomas J. Bouchard,et al.  The structure of human intelligence: It is verbal, perceptual, and image rotation (VPR), not fluid and crystallized , 2005 .

[54]  L. Luo,et al.  Axon retraction and degeneration in development and disease. , 2005, Annual review of neuroscience.

[55]  Christa Neuper,et al.  Intelligence and neural efficiency: further evidence of the influence of task content and sex on the brain-IQ relationship. , 2005, Brain research. Cognitive brain research.

[56]  Michael A. McDaniel Big-brained people are smarter: A meta-analysis of the relationship between in vivo brain volume and intelligence , 2005 .

[57]  Rex E. Jung,et al.  The neuroanatomy of general intelligence: sex matters , 2005, NeuroImage.

[58]  V. Schmithorst,et al.  Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study , 2005, Human brain mapping.

[59]  The Complexity of Everyday Life , 2005 .

[60]  Ian J. Deary,et al.  Intergenerational social mobility and mid-life status attainment: influences of childhood intelligence, childhood social factors, and education , 2005 .

[61]  L. J. Whalley,et al.  White matter integrity and cognition in childhood and old age , 2006, Neurology.

[62]  Viktor Müller,et al.  Genetic influences on dynamic complexity of brain oscillations , 2006, Neuroscience Letters.

[63]  E. Bullmore,et al.  A Resilient, Low-Frequency, Small-World Human Brain Functional Network with Highly Connected Association Cortical Hubs , 2006, The Journal of Neuroscience.

[64]  Alan C. Evans,et al.  Intellectual ability and cortical development in children and adolescents , 2006, Nature.

[65]  Philip A. Vernon,et al.  Beyond g: Putting multiple intelligences theory to the test. , 2006 .

[66]  S. F. Witelson,et al.  Intelligence and brain size in 100 postmortem brains: sex, lateralization and age factors. , 2006, Brain : a journal of neurology.

[67]  Alan C. Evans,et al.  Genetic Contributions to Human Brain Morphology and Intelligence , 2006, The Journal of Neuroscience.

[68]  Matt McGue,et al.  Genetic and environmental influences on academic achievement trajectories during adolescence. , 2006, Developmental psychology.

[69]  Jamel Chelly,et al.  Genetics and pathophysiology of mental retardation , 2006, European Journal of Human Genetics.

[70]  H.L.J. van der Maas,et al.  A dynamical model of general intelligence: the positive manifold of intelligence by mutualism. , 2006, Psychological review.

[71]  I. Deary,et al.  IQ in early adulthood and later cancer risk: cohort study of one million Swedish men. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[72]  R. Kahn,et al.  Genetic influences on human brain structure: A review of brain imaging studies in twins , 2007, Human brain mapping.

[73]  Ian J Deary,et al.  Premorbid (early life) IQ and later mortality risk: systematic review. , 2007, Annals of epidemiology.

[74]  Massimo Filippi,et al.  The effect of white matter lesions on cognition in the elderly—small but detectable , 2007, Nature Clinical Practice Neurology.

[75]  A. Tellegen,et al.  Genetic and environmental influences on the Verbal-Perceptual-Image Rotation (VPR) model of the structure of mental abilities in the Minnesota study of twins reared apart , 2007 .

[76]  Jaap J. A. Denissen,et al.  The evolutionary genetics of personality , 2007 .

[77]  Roberto Colom,et al.  General intelligence and memory span: Evidence for a common neuroanatomic framework , 2007, Cognitive neuropsychology.

[78]  Xiaohua Chen,et al.  Sex differences in regional gray matter in healthy individuals aged 44–48 years: A voxel-based morphometric study , 2007, NeuroImage.

[79]  R. Morris,et al.  The relationship between white matter brain metabolites and cognition in normal aging: The GENIE study , 2007, Brain Research.

[80]  I. Deary,et al.  Intelligence and educational achievement , 2007 .

[81]  Wendy Johnson,et al.  Genetic and environmental influences on behavior: capturing all the interplay. , 2007, Psychological review.

[82]  Lars Penke,et al.  The evolution of human intelligence and the coefficient of additive genetic variance in human brain size , 2007 .

[83]  R. Haier,et al.  The Parieto-Frontal Integration Theory (P-FIT) of intelligence: Converging neuroimaging evidence , 2007, Behavioral and Brain Sciences.

[84]  Arthur W Toga,et al.  Relationships between IQ and regional cortical gray matter thickness in healthy adults. , 2007, Cerebral cortex.

[85]  Jaap J. A. Denissen,et al.  Evolution, genes, and inter‐disciplinary personality research , 2007 .

[86]  W. Johnson,et al.  Sex differences in mental abilities: g masks the dimensions on which they lie , 2007 .

[87]  Michael C Neale,et al.  Structural brain magnetic resonance imaging of pediatric twins , 2007, Human brain mapping.

[88]  Tarmo Strenze Intelligence and socioeconomic success: A meta-analytic review of longitudinal research ☆ , 2007 .

[89]  W. Johnson,et al.  Sex Differences in Mental Ability: A Proposed Means to Link Them to Brain Structure and Function. , 2007 .

[90]  Noah A. Shamosh,et al.  Multiple Bases of Human Intelligence Revealed by Cortical Thickness and Neural Activation , 2008, The Journal of Neuroscience.

[91]  Jun Li,et al.  Brain spontaneous functional connectivity and intelligence , 2008, NeuroImage.

[92]  I. Deary,et al.  Sex Differences in Variability in General Intelligence: A New Look at the Old Question , 2008, Perspectives on psychological science : a journal of the Association for Psychological Science.

[93]  Roland Bammer,et al.  Cognitive processing speed and the structure of white matter pathways: Convergent evidence from normal variation and lesion studies , 2008, NeuroImage.

[94]  Marcus R. Munafò,et al.  Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism , 2008, Biological Psychiatry.

[95]  Ian J. Deary,et al.  Inspection time and cognitive abilities in twins aged 7 to 17 years: age-related changes, heritability and genetic covariance , 2008 .

[96]  Jun Li,et al.  White matter tract integrity and intelligence in patients with mental retardation and healthy adults , 2008, NeuroImage.

[97]  Rex E. Jung,et al.  Cognitive abilities independent of IQ correlate with regional brain structure , 2008 .

[98]  B. Williams Heritability of Intelligence , 2008 .

[99]  A. Miyake,et al.  Individual differences in executive functions are almost entirely genetic in origin. , 2008, Journal of experimental psychology. General.

[100]  Thomas J. Bouchard,et al.  Still just 1 g: Consistent results from five test batteries , 2008 .

[101]  P Rabbitt,et al.  Brain‐derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly , 2008, Genes, brain, and behavior.

[102]  Peter M Visscher,et al.  Sizing up human height variation , 2008, Nature Genetics.

[103]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[104]  Rex E. Jung,et al.  Gray matter correlates of fluid, crystallized, and spatial intelligence: Testing the P-FIT model , 2009 .

[105]  Antony Payton,et al.  The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009 , 2009, Neuropsychology Review.

[106]  Eileen Luders,et al.  Neuroanatomical Correlates of Intelligence. , 2009, Intelligence.

[107]  Karama S,et al.  Positive association between cognitive ability and cortical thickness in a representative US sample of healthy 6 to 18 year-olds , 2009, NeuroImage.

[108]  Rainer Goebel,et al.  Genetic Contribution to Variation in Cognitive Function: An fMRI Study in Twins , 2009, Science.

[109]  Guojun Bu,et al.  Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy , 2009, Nature Reviews Neuroscience.

[110]  A. Neubauer,et al.  Intelligence and neural efficiency , 2009, Neuroscience & Biobehavioral Reviews.

[111]  David Goldman,et al.  The Role of COMT Val158Met in Cognition , 2009, Biological Psychiatry.

[112]  Denise C. Park,et al.  The adaptive brain: aging and neurocognitive scaffolding. , 2009, Annual review of psychology.

[113]  I. Deary,et al.  Are Apparent Sex Differences in Mean IQ Scores Created in Part by Sample Restriction and Increased Male Variance , 2009 .

[114]  I. Deary,et al.  Genetic foundations of human intelligence , 2009, Human Genetics.

[115]  Cheuk Y. Tang,et al.  Gray Matter and Intelligence Factors: Is There a Neuro-g?. , 2009 .

[116]  T. Bouchard Genetic influence on human intelligence (Spearman's g): How much? , 2009, Annals of human biology.

[117]  Vincent J Schmithorst,et al.  DEVELOPMENTAL SEX DIFFERENCES IN THE RELATION OF NEUROANATOMICAL CONNECTIVITY TO INTELLIGENCE. , 2009, Intelligence.

[118]  Ian J. Deary,et al.  IQ in Early Adulthood and Mortality By Middle Age: Cohort Study of 1 Million Swedish Men , 2009, Epidemiology.

[119]  R. Kahn,et al.  Efficiency of Functional Brain Networks and Intellectual Performance , 2009, The Journal of Neuroscience.

[120]  M. Husain,et al.  Functional Neuroanatomy: The Locus of Human Intelligence , 2009, Current Biology.

[121]  Alan C. Evans,et al.  Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence , 2009, Human brain mapping.

[122]  Chris Rorden,et al.  Lesion Mapping of Cognitive Abilities Linked to Intelligence , 2009, Neuron.

[123]  J. P. Rushton,et al.  Whole Brain Size and General Mental Ability: A Review , 2009, The International journal of neuroscience.

[124]  Arvind Caprihan,et al.  Imaging intelligence with proton magnetic resonance spectroscopy. , 2009, Intelligence.

[125]  O. Sporns,et al.  Complex brain networks: graph theoretical analysis of structural and functional systems , 2009, Nature Reviews Neuroscience.

[126]  Agatha D. Lee,et al.  Genetics of Brain Fiber Architecture and Intellectual Performance , 2009, The Journal of Neuroscience.

[127]  Martin Lawn,et al.  A new lease of life for Thomson's bonds model of intelligence. , 2009, Psychological review.

[128]  Gail Clement,et al.  A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. , 2009, Human molecular genetics.

[129]  Jun Li,et al.  Brain Anatomical Network and Intelligence , 2009, NeuroImage.

[130]  D. Buss,et al.  The Evolution of Personality and Individual Differences , 2010 .

[131]  K. Hawkins,et al.  The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis , 2011, Neurobiology of Aging.

[132]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.