What's the Price of Low Cost?

Many programs presented at prior USU meetings have been exceptionally successful at reducing the cost of space missions. Typically this is done by a variety of mechanisms that change fundamental characteristics of how business is done in space. (The missions flown do not literally reproduce their more expensive predecessors, or they would have not have been able to significantly reduce cost.) Thus, a critical question arises – What is the price of low cost? What do we give up in order to achieve the advantage of dramatically lower cost?