Prevalence of Potentially Malignant Lesions and Oral Cancer Among Smokers in an Egyptian cohort: A Hospital-based Cross-Sectional Study

Objectives: This cross-sectional study was designed to determine the prevalence of potentially malignant lesions and oral cancer among smokers. Methods: The current observational cross-sectional study was conducted in the Clinics of Oral Medicine and Periodontology department and the Diagnostic center, Faculty of Dentistry - Cairo University in Cairo- Egypt. Smokers from all age groups and both genders who agreed to sign the informed consent were included in the study. Detailed history of tobacco consumption, different forms of tobacco use, drugs, alcohol consumption and quitting trials were recorded and followed by clinical examination and histopathological assessment of suspicious lesions. Results: Among the 1664 enrolled participants, 3.54% had leukoplakia, 2.88% had oral lichen planus, 1.5% had oral squamous cell carcinoma and 0.12% had verrucous carcinoma. Conclusion: leukoplakia was the most frequently encountered lesion followed by oral lichen planus. Dentists must be aware of the risk of smoking on oral mucosa and the early signs of developing premalignant or malignant lesions.

[1]  J. Poorolajal,et al.  Prevalence of Oral Mucosal Lesions in Male Smokers and Nonsmokers , 2013, Chonnam medical journal.

[2]  G. Taybos.  Oral Changes Associated with Tobacco Use , 2003, The American journal of the medical sciences.

[3]  S. Ibrahim,et al.  Prevalence of potentially malignant oral mucosal lesions among tobacco users in Jeddah, Saudi Arabia. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[4]  S. Behura,et al.  Oral Mucosal Lesions Associated with Smokers and Chewers - A Case-Control Study in Chennai Population. , 2015, Journal of clinical and diagnostic research : JCDR.

[5]  S. Gandolfo,et al.  The prevalence of oral mucosal lesions in adults from the Turin area. , 2008, Oral diseases.

[6]  L. Cheung,et al.  The effects of tobacco use on oral health. , 2003, Hong Kong medical journal = Xianggang yi xue za zhi.

[7]  Chao Lu,et al.  Retrospective study , 2016, Medicine.

[8]  D M Winn,et al.  Tobacco use and oral disease. , 2001, Journal of dental education.

[9]  C. Scully,et al.  Oral medicine — Update for the dental practitioner Aphthous and other common ulcers , 2005, British Dental Journal.

[10]  Shan P. Mohammad,et al.  Prevalence of oral premalignant and malignant Lesions among referred Kurdish patients Attending Department of Oral and Maxilofasial in Sulaimani Teaching Hospital , 2014 .

[11]  H. Adami,et al.  Tobacco use, cancer causation and public health impact , 2002, Journal of internal medicine.

[12]  A. Mehmood,et al.  Oral mucosal disorders associated with habitual gutka usage: a review. , 2010, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[13]  L. Sandvik,et al.  Evaluation of Oral Mucosal Lesions in 598 Referred Iranian Patients , 2009, The open dentistry journal.

[14]  Varun Rastogi,et al.  An Insight to Oral Epithelial Dysplasia , 2013 .

[15]  Nor Atika Md Ashar,et al.  Prevalence of oral cancer, oral potentially malignant disorders and other oral mucosal lesions in Cambodia , 2018, Ethnicity & health.

[16]  Y. Ko,et al.  The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan , 2003, British Journal of Cancer.

[17]  K Davidson,et al.  TOBACCO-SMOKING , 1889, Science.

[18]  S. Warnakulasuriya,et al.  Oral cancer survival in young people in South East England. , 2007, Oral oncology.

[19]  R. Mesquita,et al.  Tobacco use increase the number of aneuploid nuclei in the clinically healthy oral epithelium. , 2010, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[20]  K. Ranganathan,et al.  Prevalence of oral lesions in relation to habits: Cross-sectional study in South India. , 2006, Indian journal of dental research : official publication of Indian Society for Dental Research.

[21]  H. Singh,et al.  An Update on Precancerous Lesions of Oral Cavity , 2013 .

[22]  A. Nassar,et al.  Prevalence of oral cancer and potentially malignant lesions among shammah users in Yemen. , 2007, Oral oncology.

[23]  D. Sujatha,et al.  Prevalence and correlation of oral lesions among tobacco smokers, tobacco chewers, areca nut and alcohol users. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[24]  A. Steptoe,et al.  Health-related behaviors in older adults relationships with socioeconomic status. , 2010, American journal of preventive medicine.

[25]  S. Warnakulasuriya.  Causes of oral cancer – an appraisal of controversies , 2009, BDJ.

[26]  P. Patil,et al.  Prevalence of oral mucosal lesions in dental patients with tobacco smoking, chewing, and mixed habits: A cross-sectional study in South India , 2013, Journal of family & community medicine.

[27]  T. Devaki,et al.  Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India , 2018, Journal of International Society of Preventive & Community Dentistry.

[28]  G. Ogden.  Alcohol and oral cancer. , 2005, Alcohol.