New and Effective Synthesis of 7-Triethylsilylbaccatin III from 7β,13α-Bistriethylsiloxy-1β,2α,10β-trihydroxy-9-oxo-4(20),11-taxadiene

7β,13α-Bistriethylsiloxy-1β,2α,10β-trihydroxy-9-oxo-4(20),11-taxadiene (2), derived from 10-deacetylbaccatin III via degradation of oxetane ring, was conveniently converted into 7-triethylsilylbaccatin III (1) by way of a new and effective method for constructing oxetane ring. Thus, the synthesis of a precursor of taxol from novel taxoid 2 was accomplished.

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