Sulforaphane Induces Glioprotection After LPS Challenge

[1]  Xiang Ren,et al.  Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose via regulating endoplasmic reticulum , 2020, Neurochemistry International.

[2]  S. David,et al.  Immune cell regulation of glia during CNS injury and disease , 2020, Nature Reviews Neuroscience.

[3]  A. Molofsky,et al.  Astrocytes and Microglia: In Sickness and in Health , 2020, Trends in Neurosciences.

[4]  Katsuhiko Suzuki,et al.  Protective Effects of Sulforaphane on Exercise-Induced Organ Damage via Inducing Antioxidant Defense Responses , 2020, Antioxidants.

[5]  L. Cai,et al.  Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function. , 2020, Trends in molecular medicine.

[6]  A. Mamun,et al.  Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. , 2019, The Science of the total environment.

[7]  Ying Wang,et al.  Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes , 2019, Neuroscience Letters.

[8]  D. Rossi,et al.  Astrocytes: Emerging Therapeutic Targets in Neurological Disorders. , 2019, Trends in molecular medicine.

[9]  L. Bobermin,et al.  Adenosine receptors as a new target for resveratrol-mediated glioprotection. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[10]  A. Schousboe Metabolic signaling in the brain and the role of astrocytes in control of glutamate and GABA neurotransmission , 2018, Neuroscience Letters.

[11]  A. Araque,et al.  Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism , 2018, Nature Neuroscience.

[12]  A. Belló-Klein,et al.  Sulforaphane effects on oxidative stress parameters in culture of adult cardiomyocytes. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[13]  A. Santamaría,et al.  Redox Signaling, Neuroinflammation, and Neurodegeneration. , 2017, Antioxidants & redox signaling.

[14]  Nicola J. Allen,et al.  Cell Biology of Astrocyte-Synapse Interactions , 2017, Neuron.

[15]  J. R. Liddell,et al.  Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration? , 2017, Antioxidants.

[16]  S. Friend,et al.  Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes , 2017, Science Translational Medicine.

[17]  T. Roger,et al.  Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype , 2017, Molecular Neurobiology.

[18]  C. Gonçalves,et al.  Fluctuations in glucose levels induce glial toxicity with glutamatergic, oxidative and inflammatory implications. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[19]  D. Souza,et al.  Resveratrol modulates GSH system in C6 astroglial cells through heme oxygenase 1 pathway , 2017, Molecular and Cellular Biochemistry.

[20]  C. Farina,et al.  Astrocytes: Key Regulators of Neuroinflammation. , 2016, Trends in immunology.

[21]  K. Takano,et al.  Acetate Attenuates Lipopolysaccharide-Induced Nitric Oxide Production Through an Anti-Oxidative Mechanism in Cultured Primary Rat Astrocytes , 2016, Neurochemical Research.

[22]  N. Khaper,et al.  Sulforaphane effects on postinfarction cardiac remodeling in rats: modulation of redox-sensitive prosurvival and proapoptotic proteins. , 2016, The Journal of nutritional biochemistry.

[23]  J. Bolaños Bioenergetics and redox adaptations of astrocytes to neuronal activity , 2016, Journal of neurochemistry.

[24]  S. Ryter,et al.  Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. , 2016, Translational research : the journal of laboratory and clinical medicine.

[25]  D. Souza,et al.  Ammonia impairs glutamatergic communication in astroglial cells: protective role of resveratrol. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[26]  C. Nath,et al.  Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway , 2015, Molecular Neurobiology.

[27]  C. Gonçalves,et al.  Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway , 2015, Purinergic Signalling.

[28]  D. Souza,et al.  Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[29]  C. Avendaño,et al.  Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. , 2015, Molecular nutrition & food research.

[30]  N. Sharma,et al.  Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation , 2015, Neurochemistry International.

[31]  Stephanie M. Tortorella,et al.  Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. , 2015, Antioxidants & redox signaling.

[32]  Qiang Sun,et al.  Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia , 2015, Journal of Molecular Neuroscience.

[33]  P. Kochanek,et al.  2′,3′-cAMP, 3′-AMP, 2′-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors , 2015, Brain Research.

[34]  Wei Liu,et al.  Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway , 2016, Molecular Neurobiology.

[35]  N. Khaper,et al.  Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiac myoblasts , 2014, Molecular and Cellular Biochemistry.

[36]  M. Pu,et al.  Sulforaphane Protects Rodent Retinas against Ischemia-Reperfusion Injury through the Activation of the Nrf2/HO-1 Antioxidant Pathway , 2014, PloS one.

[37]  V. Nizet,et al.  HIF transcription factors, inflammation, and immunity. , 2014, Immunity.

[38]  T. Oberyszyn,et al.  Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane. , 2014, Molecular nutrition & food research.

[39]  P. Barker,et al.  S100B protein activates a RAGE‐dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis , 2014, Journal of neurochemistry.

[40]  Hongmin Wang,et al.  Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease , 2014, Journal of neurochemistry.

[41]  Y. Ao,et al.  Heterogeneity of reactive astrocytes , 2014, Neuroscience Letters.

[42]  Jijun Chen Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications , 2014, Reviews in the neurosciences.

[43]  S. Niture,et al.  Regulation of Nrf2-an update. , 2014, Free radical biology & medicine.

[44]  K. Varani,et al.  A(1) and A(3) adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes. , 2013, Pharmacological research.

[45]  P. Hrelia,et al.  Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases , 2013, Oxidative medicine and cellular longevity.

[46]  J. De Keyser,et al.  Immune Players in the CNS: The Astrocyte , 2013, Journal of Neuroimmune Pharmacology.

[47]  N. Patel,et al.  GDNF, NGF and BDNF as therapeutic options for neurodegeneration. , 2013, Pharmacology & therapeutics.

[48]  Shelly C. Lu Glutathione synthesis. , 2013, Biochimica et biophysica acta.

[49]  D. Souza,et al.  Resveratrol Prevents Ammonia Toxicity in Astroglial Cells , 2012, PloS one.

[50]  F. Campos,et al.  Astrocyte-derived GDNF is a potent inhibitor of microglial activation , 2012, Neurobiology of Disease.

[51]  Pierre J Magistretti,et al.  Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. , 2011, Cell metabolism.

[52]  T. Kielian,et al.  Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. , 2011, Clinical science.

[53]  David E. Williams,et al.  Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice , 2011, Pharmaceutical Research.

[54]  A. Planas,et al.  Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways , 2011, Glia.

[55]  O. Hammarsten,et al.  Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage , 2011, Neuropharmacology.

[56]  M. Leite,et al.  Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats , 2011, Journal of Neuroinflammation.

[57]  T. Kensler,et al.  When NRF2 talks, who's listening? , 2010, Antioxidants & redox signaling.

[58]  Yu Tian Wang,et al.  Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[59]  P. Kochanek,et al.  Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. , 2010, Journal of neurotrauma.

[60]  W. Fu,et al.  The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression , 2010, Neuropharmacology.

[61]  F. Brozzi,et al.  S100B's double life: intracellular regulator and extracellular signal. , 2009, Biochimica et biophysica acta.

[62]  G. Fiskum,et al.  Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation , 2009, Glia.

[63]  J. Allard,et al.  Dietary activators of Sirt1 , 2009, Molecular and Cellular Endocrinology.

[64]  DelindaA . Johnson,et al.  Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis , 2008, The Journal of Neuroscience.

[65]  M. Leite,et al.  Biological and methodological features of the measurement of S100B, a putative marker of brain injury. , 2008, Clinical biochemistry.

[66]  S. Park,et al.  Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-γ-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase , 2008, Neurochemistry International.

[67]  C. Gottfried,et al.  A simple, sensitive and widely applicable ELISA for S100B: Methodological features of the measurement of this glial protein , 2008, Journal of Neuroscience Methods.

[68]  W. Aird,et al.  NADPH Oxidase Activity Selectively Modulates Vascular Endothelial Growth Factor Signaling Pathways* , 2007, Journal of Biological Chemistry.

[69]  C. Gottfried,et al.  Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. , 2006, Archives of biochemistry and biophysics.

[70]  B. Lukomska,et al.  The role of astrocytes in the physiology and pathology of the central nervous system. , 2006, Acta neurobiologiae experimentalis.

[71]  K. Takeda [Toll-like receptor]. , 2005, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[72]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[73]  M. Wajner,et al.  Methylmalonate administration decreases Na+,K+‐ATPase activity in cerebral cortex of rats , 2000, Neuroreport.

[74]  K. Chan,et al.  A direct colorimetric assay for Ca2+ -stimulated ATPase activity. , 1986, Analytical biochemistry.

[75]  A. Meister,et al.  Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney. , 1985, Methods in enzymology.

[76]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.

[77]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.