Should Tenecteplase be Given in Clinical Practice for Acute Ischemic Stroke Thrombolysis?

Supplemental Digital Content is available in the text.

[1]  A. Perrier,et al.  Safety and efficacy of tenecteplase versus alteplase in acute coronary syndrome: a systematic review and meta-analysis of randomized trials , 2016, Archives of medical science : AMS.

[2]  H. Rodbard,et al.  Reduced Risk of Confirmed Hypoglycemia (Plasma Glucose <2.3 mmol/L) with Insulin Degludec vs. Insulin Glargine in Patients with Type 2 Diabetes: A Meta-analysis of 5 Randomized Trials , 2013 .

[3]  J. Grotta,et al.  Phase IIB/III Trial of Tenecteplase in Acute Ischemic Stroke: Results of a Prematurely Terminated Randomized Clinical Trial , 2010, Stroke.

[4]  S. Laporte,et al.  Impact of double‐blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta‐analysis , 2013, Journal of thrombosis and haemostasis : JTH.

[5]  I. Ford,et al.  Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study , 2015, The Lancet Neurology.

[6]  S. Warach,et al.  Stroke Thrombolysis With Tenecteplase to Reduce Emergency Department Spread of Coronavirus Disease 2019 and Shortages of Alteplase. , 2020, JAMA Neurology.

[7]  J. Assmus,et al.  Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial , 2017, The Lancet Neurology.

[8]  M. Krause,et al.  Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke , 2018, The New England journal of medicine.

[9]  D. Combs,et al.  Pharmacokinetics and Pharmacodynamics of Tenecteplase in Fibrinolytic Therapy of Acute Myocardial Infarction , 2002, Clinical pharmacokinetics.

[10]  J. Saver,et al.  Evidence that Tenecteplase Is Noninferior to Alteplase for Acute Ischemic Stroke. , 2019, Stroke.

[11]  R. Sacco,et al.  Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke. , 2019, Stroke.

[12]  M. May,et al.  Bolus-Infusion Delays of Alteplase during Thrombolysis in Acute Ischaemic Stroke and Functional Outcome at 3 Months , 2014, Stroke research and treatment.

[13]  Yongjun Wang,et al.  Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases , 2020, Stroke and vascular neurology.

[14]  D. Botstein,et al.  A faster-acting and more potent form of tissue plasminogen activator. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[15]  B. Keyt,et al.  Real-Time Measurement of Lysis of Mural Platelet Deposits by Fibrinolytic Agents under Arterial Flow , 1998, Annals of Biomedical Engineering.

[16]  Correction to: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. , 2019, Stroke.

[17]  A. Majid,et al.  The Influence of Bolus to Infusion Delays on Plasma Tissue Plasminogen Activator Levels , 2014, International journal of stroke : official journal of the International Stroke Society.

[18]  Deepak L. Bhatt,et al.  Tenecteplase versus alteplase for management of acute ischemic stroke: a pairwise and network meta-analysis of randomized clinical trials , 2018, Journal of Thrombosis and Thrombolysis.

[19]  G. Donnan,et al.  A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. , 2012, The New England journal of medicine.

[20]  P. Lapchak,et al.  Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits , 2004, Experimental Neurology.

[21]  S. Warach,et al.  Tenecteplase Thrombolysis for Acute Ischemic Stroke. , 2020, Stroke.

[22]  B. Campbell,et al.  Routine Use of Tenecteplase for Thrombolysis in Acute Ischemic Stroke , 2021, Stroke.

[23]  Ana Catarina Fonseca,et al.  European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke , 2021, European stroke journal.

[24]  S. Warach,et al.  Abstract P2: Results of a Prospective Observational Cohort Study of Tenecteplase as Standard of Care Stroke Thrombolytic , 2021 .

[25]  W. Powers,et al.  Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. , 2019, Stroke.