miR‐137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6

MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR‐137 in the pathogenesis of lung cancer. The downregulation of miR‐137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR‐137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR‐137.

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