Intraoperative Post Partum Hemorrhage in a Patient with Dengue Fever

SUMMARY A 33 year old obstetric patient with mild fever of undiagnosed etiology underwent emergency caesarean section under general anesthesia. She had platelet count of 98,000 per microliter and increased APTT of 37.8 s at the time of surgery. After uneventful anesthetic induction and delivery of fetus, slow and oozing type of bleeding led to massive hemorrhage. Patient remained vitally stable throughout perioperative phase and was extubated. Next day, patient’s dengue IgM antibody was reported positive. Neonate was well and his dengue test was negative. Pregnant women are at high risk of developing severe complications of dengue fever with unclear mechanisms related to impaired coagulation. Regional anesthesia may not have safe outcome due to dengue infection.

[1]  Ayesha Farooq,et al.  Dengue and malaria infections in pregnancy , 2020, Wiener klinische Wochenschrift.

[2]  R. Desouza,et al.  Thrombocytopenia in Pregnancy Nearing Term: A Clinical Analysis , 2019, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

[3]  Shalendra Singh,et al.  Pregnancy with dengue hemorrhagic fever in respiratory distress for cesarean delivery: Anesthetic management , 2019, Journal of Anaesthesiology Clinical Pharmacology.

[4]  D. Vijayan,et al.  Thromboelastographic Analysis of Hemostatic Abnormalities in Dengue Patients Admitted in a Multidisciplinary Intensive Care Unit: A Cross-sectional Study , 2018, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

[5]  O. Lortholary,et al.  Arboviruses and pregnancy: maternal, fetal, and neonatal effects. , 2017, The Lancet. Child & adolescent health.

[6]  Syed R Hasan,et al.  Characteristics and outcome of dengue infection; clinical perspective from a secondary care hospital of Karachi , 2012, Pakistan journal of medical sciences.

[7]  V. Paz-Soldan,et al.  Maternal dengue and pregnancy outcomes: a systematic review. , 2010, Obstetrical & gynecological survey.

[8]  J. Farrar,et al.  Hemostatic changes in Vietnamese children with mild dengue correlate with the severity of vascular leakage rather than bleeding. , 2009, The American journal of tropical medicine and hygiene.

[9]  N. Malhotra,et al.  Anesthetic management of a pregnant patient with dengue hemorrhagic fever for emergency cesarean section. , 2006, International journal of obstetric anesthesia.

[10]  P. W. Chan,et al.  Risk factors for hemorrhage in severe dengue infections. , 2002, The Journal of pediatrics.