Recipient of the 2017 IETS Pioneer Award: Prof. Dr. Heiner Niemann.

Heiner Niemann was born on 7th January 1953 in Münster, Westphalia, Germany. After completing obligatory military service, he began to studyVeterinaryMedicine at the Veterinary University Hannover in 1973. In 1978, Heiner Niemann graduated and started the experiments for his doctoral thesis at the Institute for Farm Animal Breeding and Behaviour (FAL) in Mariensee. Two years later, in 1980, he received his doctoral degree (Dr med. vet.), from the University of Veterinary Medicine in Hannover for his thesis entitled ‘Fluorescence microscopic evaluation of the viability of early embryonic stages of rabbits and cattle by FDA [3060-Fluorescein-Diacetyl]and DAPI [4060-Diamidino-2-Phenylindol]-Test’. In 1984, he became a Veterinary specialist in reproductive medicine and in 2001 in molecular genetics and gene technology. Heiner finalised his habilitation thesis entitled ‘Biotechnological studies on preimplantation embryos from cattle and swine’ in 1984 and received the Venia legendi in reproductive medicine from the Veterinary University Hannover. Since then he has been a Faculty member of this University. He teaches general and specific aspects of animal breeding, holds clinical demonstrations about reproductive biotechnology and seminars within the PhD program. In parallel, he gives lectures and seminars within the PhD programs ‘Molecular Medicine’ and ‘Regenerative Sciences’ at the Medical University Hannover. Furthermore, he is a lecturer at the Christian Albrecht University Kiel (Germany) and at the University of Applied Sciences South Westphalia (Germany). He has been the supervisor for more than 85 dissertations (mainly Dr med. vet.), three diploma theses and three habilitations. In 1980, Heiner Niemann became a member of the scientific staff at the Institute for Farm Animal Breeding and Behaviour (FAL) in Mariensee, since 2008 he has been the Head of the Institute, now called Institute of Farm Animal Genetics of the Friedrich-Loeffler-Institute (FLI). The Institute advises the Federal Ministry of Agriculture on all aspects of farm animal genetics. In 1985–1986, he spent some months at the Veterinary College, Texas A&M University as a Visiting Professor. Since 1994, he has been an Adjunct Professor for Reproductive Biology at the Veterinary University Hannover. During 2004 to 2007, he was appointed as Adjunct Professor at the Monash University in Melbourne, Australia. Furthermore, since 2008 Heiner has been a Faculty member and since 2016 Honorary Professor of the Medical University Hannover (MHH). Heiner stayed at the Institute in Mariensee despite receiving several offers for academic positions from all over the world, by the Royal Veterinary and Agricultural University Copenhagen, Denmark (1998); the Monash University Melbourne, Australia (2001); the Faculty ofVeterinaryMedicine ofUtrechtUniversity, the Netherlands (2006), and the University of Adelaide, Australia (2007). Since 2007, he has been a Visiting Professor at the Institute of Advanced Technologies of Kinki University Wakayama, Japan. Heiner’s expertise to conduct, organise and lead research competitively has led to appointments in several national and international committees, including Arpac International (1987), WHO Expert Committee (Transgenic animals and safety of products thereof, 2007), EFSA (European FoodSafetyAuthority) expert committee (Safety of somatic cloning of animals and their products, GM animals, 2007/2008; 2009/2010). In 2007, 2010 and 2013 he was elected as Chairperson of the DGfZ (Deutsche Gesellschaft für Züchtungskunde, German Society for Animal Production) Advisory Board. This brief list shows that he became widely recognised, not only in Germany. He was able to successfully apply for competitive third-party and external funding from the DFG (Deutsche Forschungsgemeinschaft, GermanResearch Foundation), the EuropeanUnion (EU), the Federal government, animal breeding organisations and industry. In the Excellence in Science and Research Initiative from the DFG at the Medical University of Hannover, he participated in ‘Rebirth I and II’ (2006–2017). Recently, Heiner was granted financial support for a Reinhart Koselleck Project for innovative and high risk research (2016–2020). Heiner has published more than 600 articles, ,370 in international peer-reviewed journals of various research fields, more than 250 abstracts, and around 90 book contributions. Therefore, he is listed among the top ten most cited scientists in CSIRO PUBLISHING

[1]  H. Niemann,et al.  Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes , 2016, Xenotransplantation.

[2]  E. Wolf,et al.  Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing , 2016, Scientific Reports.

[3]  H. Niemann,et al.  The production of multi-transgenic pigs: update and perspectives for xenotransplantation , 2016, Transgenic Research.

[4]  F. le Noble,et al.  MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2 , 2014, Nature Communications.

[5]  H. Niemann,et al.  Somatic cell nuclear transfer cloning: practical applications and current legislation. , 2012, Reproduction in domestic animals = Zuchthygiene.

[6]  F. Strejček,et al.  Early aberrations in chromatin dynamics in embryos produced under in vitro conditions. , 2012, Cellular reprogramming.

[7]  Yolanda Santiago,et al.  Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases , 2011, Proceedings of the National Academy of Sciences.

[8]  T. Haaf,et al.  Epigenetic profile of developmentally important genes in bovine oocytes , 2011, Molecular reproduction and development.

[9]  W. A. Kuesa,et al.  Correction for Kues et al., Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo , 2009, Proceedings of the National Academy of Sciences.

[10]  M. Manns,et al.  Telomere length is reset during early mammalian embryogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[11]  C. Wrenzycki,et al.  Cellular and Molecular Deviations in Bovine In Vitro-Produced Embryos Are Related to the Large Offspring Syndrome1 , 2002, Biology of reproduction.

[12]  T. Brambrink,et al.  Application of cDNA arrays to monitor mRNA profiles in single preimplantation mouse embryos. , 2002, BioTechniques.

[13]  H. Niemann,et al.  Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep , 1999, Transgenic Research.

[14]  C. Wrenzycki,et al.  Expression of the gap junction gene connexin43 (Cx43) in preimplantation bovine embryos derived in vitro or in vivo. , 1996, Journal of reproduction and fertility.

[15]  H. Niemann,et al.  Pluripotent cells in farm animals: state of the art and future perspectives. , 2012, Reproduction, fertility, and development.

[16]  H. Niemann,et al.  From fibroblasts and stem cells: implications for cell therapies and somatic cloning. , 2005, Reproduction, fertility, and development.

[17]  C. Wrenzycki,et al.  Messenger RNA expression patterns in bovine embryos derived from in vitro procedures and their implications for development. , 2005, Reproduction, fertility, and development.

[18]  C. Wrenzycki,et al.  Epigenetic reprogramming in early embryonic development: effects of in-vitro production and somatic nuclear transfer. , 2003, Reproductive biomedicine online.

[19]  C. Wrenzycki,et al.  Effects of in vivo prematuration and in vivo final maturation on developmental capacity and quality of pre-implantation embryos. , 2002, Theriogenology.

[20]  C Wrenzycki,et al.  Alterations of expression of developmentally important genes in preimplantation bovine embryos by in vitro culture conditions: implications for subsequent development. , 2000, Theriogenology.

[21]  H. Niemann Cryopreservation of ova and embryos from livestock: Current status and research needs , 1991 .

[22]  H. Niemann,et al.  Uptake and effects of ovarian steroids in the early pig embryo: In vitro and in vivo studies , 1984 .