Current reprogramming methods to generate high-quality iPSCs

[1]  Jungho Kim,et al.  Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. , 2008, The international journal of biochemistry & cell biology.

[2]  S. Yagi,et al.  Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency , 2012, Epigenetics.

[3]  Anna-Katerina Hadjantonakis,et al.  Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst , 2008, Development.

[4]  J. Utikal,et al.  Induced Pluripotent Stem Cells Generated Without Viral Integration , 2008, Science.

[5]  R. Blelloch,et al.  miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. , 2013, Cell reports.

[6]  Yoshifumi Kawamura,et al.  Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1 , 2011, Nature.

[7]  J. Miyazaki,et al.  Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells , 2000, Nature Genetics.

[8]  A. Chan,et al.  Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells. , 2008, Reproduction.

[9]  J. Ecker,et al.  ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. , 2015, Cell stem cell.

[10]  Jonghwan Kim,et al.  Transcription Elongation Factor Tcea3 Regulates the Pluripotent Differentiation Potential of Mouse Embryonic Stem Cells Via the Lefty1‐Nodal‐Smad2 Pathway , 2013, Stem cells.

[11]  M. Fritsch,et al.  Dynamic Changes in Histone H3 Phosphoacetylation during Early Embryonic Stem Cell Differentiation Are Directly Mediated by Mitogen- and Stress-activated Protein Kinase 1 via Activation of MAPK Pathways* , 2006, Journal of Biological Chemistry.

[12]  M. Murakami,et al.  The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells , 2003, Cell.

[13]  Stuart H. Orkin,et al.  A protein interaction network for pluripotency of embryonic stem cells , 2006, Nature.

[14]  Hans R Schöler,et al.  Regulatory circuits underlying pluripotency and reprogramming. , 2009, Trends in pharmacological sciences.

[15]  R. Jaenisch,et al.  Induced Pluripotent Stem Cells Meet Genome Editing. , 2016, Cell stem cell.

[16]  S. Baylin,et al.  Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes , 2010, Stem cells.

[17]  X. Tian,et al.  Functionality and transduction condition evaluation of recombinant Klf4 for improved reprogramming of iPS cells. , 2011, Cellular reprogramming.

[18]  K. Eto,et al.  Ten years of induced pluripotency: from basic mechanisms to therapeutic applications , 2016, Development.

[19]  Robert Lanza,et al.  Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. , 2009, Cell stem cell.

[20]  George Q. Daley,et al.  Reprogramming of human somatic cells to pluripotency with defined factors , 2008, Nature.

[21]  Johanna E. Goldmann,et al.  Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion. , 2015, Human gene therapy.

[22]  A. Rizzino,et al.  DNA microarray analyses of genes regulated during the differentiation of embryonic stem cells , 2000, Molecular reproduction and development.

[23]  Robert L. Judson,et al.  Embryonic stem cell–specific microRNAs promote induced pluripotency , 2009, Nature Biotechnology.

[24]  Naoki Nishishita,et al.  Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors , 2011, Proceedings of the National Academy of Sciences.

[25]  P. Savatier,et al.  Krüppel-like transcription factors and control of pluripotency , 2010, BMC Biology.

[26]  A. Rizzino,et al.  Small Increases in the Level of Sox2 Trigger the Differentiation of Mouse Embryonic Stem Cells , 2008, Stem cells.

[27]  D. Melton,et al.  "Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells , 2002, Science.

[28]  Rudolf Jaenisch,et al.  Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors , 2009, Cell.

[29]  Marius Wernig,et al.  c-Myc is dispensable for direct reprogramming of mouse fibroblasts. , 2008, Cell stem cell.

[30]  F. Gage,et al.  Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience , 2016, Nature Reviews Neuroscience.

[31]  H. Schöler,et al.  A combined chemical and genetic approach for the generation of induced pluripotent stem cells. , 2008, Cell stem cell.

[32]  H. Schöler,et al.  Stem cell pluripotency and transcription factor Oct4 , 2002, Cell Research.

[33]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[34]  H. Schöler,et al.  Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. , 1994, Developmental biology.

[35]  Megan Scudellari How iPS cells changed the world , 2016, Nature.

[36]  W. L. Ruzzo,et al.  MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries , 2008, Stem cells.

[37]  Wenjun Guo,et al.  Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds , 2008, Nature Biotechnology.

[38]  E. Wanker,et al.  HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2 , 2014, Stem cells.

[39]  H. Schöler,et al.  Developmental cell biology: Regulatory networks in embryo-derived pluripotent stem cells , 2005, Nature Reviews Molecular Cell Biology.

[40]  Y. Yan,et al.  Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. , 2000, Development.

[41]  J. Renard,et al.  Cloned rabbits produced by nuclear transfer from adult somatic cells , 2002, Nature Biotechnology.

[42]  N. Nakatsuji,et al.  Role of SOX2 in maintaining pluripotency of human embryonic stem cells , 2010, Genes to cells : devoted to molecular & cellular mechanisms.

[43]  P. Kolatkar,et al.  The SOX transcription factors as key players in pluripotent stem cells. , 2014, Stem cells and development.

[44]  M. Hasegawa,et al.  Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome , 2009, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[45]  Deepak M. Gupta,et al.  A nonviral minicircle vector for deriving human iPS cells , 2010, Nature Methods.

[46]  W. Wong,et al.  Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming , 2012, Cell.

[47]  Peter G Schultz,et al.  Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 , 2009, Proceedings of the National Academy of Sciences.

[48]  Gwangil Kim,et al.  Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells. , 2014, Stem cells and development.

[49]  V. Kim,et al.  Regulation of microRNA biogenesis , 2014, Nature Reviews Molecular Cell Biology.

[50]  J. Nichols,et al.  Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. , 2009, Cell stem cell.

[51]  S. Dalton,et al.  LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism , 2005, Development.

[52]  Sandy L. Klemm,et al.  Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase , 2012, Cell.

[53]  G. Daley,et al.  Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. , 2012, Cell stem cell.

[54]  Shinsuke Yuasa,et al.  Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. , 2010, Cell stem cell.

[55]  Dajiang Qin,et al.  Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells. , 2010, Journal of genetics and genomics = Yi chuan xue bao.

[56]  Hans R. Schöler,et al.  Establishment of totipotency does not depend on Oct4A , 2013, Nature Cell Biology.

[57]  S. Futaki,et al.  Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment , 2009, The AAPS Journal.

[58]  G. Daley,et al.  Lin28: A MicroRNA Regulator with a Macro Role , 2010, Cell.

[59]  W. Cui,et al.  Sox2, a key factor in the regulation of pluripotency and neural differentiation. , 2014, World journal of stem cells.

[60]  H. Ng,et al.  KLF4 and PBX1 Directly Regulate NANOG Expression in Human Embryonic Stem Cells , 2009, Stem cells.

[61]  L. Guarente,et al.  Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis , 2017, Nature Cell Biology.

[62]  Mark J. Murphy,et al.  c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. , 2004, Genes & development.

[63]  Y Tsunoda,et al.  Eight calves cloned from somatic cells of a single adult. , 1998, Science.

[64]  Andre Terzic,et al.  Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells , 2007, Nature Clinical Practice Cardiovascular Medicine.

[65]  Carl O. Pabo,et al.  Cellular uptake of the tat protein from human immunodeficiency virus , 1988, Cell.

[66]  J. Nolta,et al.  Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells , 2014, Stem cells.

[67]  M. Son,et al.  Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers , 2013, Stem cells.

[68]  Yutao Du,et al.  Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression. , 2012, Cell stem cell.

[69]  Merlin Crossley,et al.  Krüppel-like transcription factors: a functional family. , 2008, The international journal of biochemistry & cell biology.

[70]  H. Schöler,et al.  Generation of Human‐Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 , 2009, Stem cells.

[71]  C. Zeiss,et al.  A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels , 2004, Development.

[72]  G. Orphanides,et al.  Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. , 2005, Molecular cell.

[73]  Sheng Ding,et al.  Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. , 2009, Cell stem cell.

[74]  R. Lafyatis,et al.  Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette , 2010, Stem cells.

[75]  William Ritchie,et al.  Genome-wide characterization of the routes to pluripotency , 2014, Nature.

[76]  H. Deng,et al.  A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming , 2015, Cell.

[77]  Takashi Aoi,et al.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts , 2008, Nature Biotechnology.

[78]  S. Yamanaka,et al.  The Use of Induced Pluripotent Stem Cells in Drug Development , 2011, Clinical pharmacology and therapeutics.

[79]  Mo Li,et al.  Looking to the future following 10 years of induced pluripotent stem cell technologies , 2016, Nature Protocols.

[80]  B. Lim,et al.  Oocyte Factors Suppress Mitochondrial Polynucleotide Phosphorylase to Remodel the Metabolome and Enhance Reprogramming. , 2015, Cell reports.

[81]  Wenjun Guo,et al.  Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 , 2008, Nature Biotechnology.

[82]  D. Beach,et al.  A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. , 2006, Antioxidants & redox signaling.

[83]  Ron Shamir,et al.  Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell Signature Dominated by a Single Seed Sequence , 2008, Stem cells.

[84]  J. Lenormand,et al.  Targeted release of transcription factors for human cell reprogramming by ZEBRA cell-penetrating peptide. , 2017, International journal of pharmaceutics.

[85]  P. Robson,et al.  Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages. , 2008, Cell stem cell.

[86]  Grace X. Y. Zheng,et al.  A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells , 2011, PLoS genetics.

[87]  Hyun-Jai Cho,et al.  Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation. , 2010, Blood.

[88]  Juan Carlos Izpisua Belmonte,et al.  The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming , 2011, Cell Research.

[89]  Ryan E. Mills,et al.  Increased Genomic Integrity of an Improved Protein‐Based Mouse Induced Pluripotent Stem Cell Method Compared With Current Viral‐Induced Strategies , 2014, Stem cells translational medicine.

[90]  J. Nichols,et al.  Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells , 2003, Cell.

[91]  Zhonghui Zhang,et al.  MicroRNA-302/367 Cluster Governs hESC Self-Renewal by Dually Regulating Cell Cycle and Apoptosis Pathways , 2015, Stem cell reports.

[92]  Jialiang Liang,et al.  A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. , 2010, Cell stem cell.

[93]  M. Blasco,et al.  The Ink4/Arf locus is a barrier for iPS cell reprogramming , 2009, Nature.

[94]  Andre Terzic,et al.  Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. , 2011, Cell metabolism.

[95]  H. Deng,et al.  Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds , 2013, Science.

[96]  J. Gurdon,et al.  Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? , 2011, Nature Reviews Molecular Cell Biology.

[97]  M. Thier,et al.  Cellular Reprogramming Employing Recombinant Sox2 Protein , 2012, Stem cells international.

[98]  Sheng Ding,et al.  Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. , 2008, Cell stem cell.

[99]  H. Redl,et al.  Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. , 2010, Cell stem cell.

[100]  Jing Chen,et al.  BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone , 2011, Cell Research.

[101]  Philip R. Cohen,et al.  MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells , 2000, FEBS letters.

[102]  P. Collas,et al.  Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. , 2005, Molecular biology of the cell.

[103]  Tohru Kimura,et al.  Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting , 2015, Nature Communications.

[104]  Martin H. Teicher,et al.  Human Autologous iPSC-Derived Dopaminergic Progenitors Restore Motor Function in Parkinson's Disease Models. , 2019, The Journal of clinical investigation.

[105]  Mike J. Mason,et al.  Role of the Murine Reprogramming Factors in the Induction of Pluripotency , 2009, Cell.

[106]  J. Miyazaki,et al.  Klf4 Cooperates with Oct3/4 and Sox2 To Activate the Lefty1 Core Promoter in Embryonic Stem Cells , 2006, Molecular and Cellular Biology.

[107]  R. Eisenman,et al.  N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. , 2002, Genes & development.

[108]  H. Rohrer,et al.  Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis , 2010, PLoS biology.

[109]  X. Chen,et al.  The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells , 2006, Nature Genetics.

[110]  S. Saladi,et al.  ATP Dependent Chromatin Remodeling Enzymes in Embryonic Stem Cells , 2010, Stem Cell Reviews and Reports.

[111]  Shinya Yamanaka,et al.  Promotion of direct reprogramming by transformation-deficient Myc , 2010, Proceedings of the National Academy of Sciences.

[112]  S. Yamanaka,et al.  Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation , 2014, Cell.

[113]  Alexander Meissner,et al.  Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. , 2010, Cell stem cell.

[114]  Jason P Awe,et al.  Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis. , 2013, Cellular reprogramming.

[115]  C. Allis,et al.  Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. , 2000, Molecular cell.

[116]  P. Burridge,et al.  MicroRNA‐302 Increases Reprogramming Efficiency via Repression of NR2F2 , 2013, Stem cells.

[117]  Xin Li,et al.  A comparison of non-integrating reprogramming methods , 2014, Nature Biotechnology.

[118]  S. Yamanaka,et al.  Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts , 2013, Proceedings of the National Academy of Sciences.

[119]  Sheng Zhong,et al.  A core Klf circuitry regulates self-renewal of embryonic stem cells , 2008, Nature Cell Biology.

[120]  G. Daley,et al.  The promise of induced pluripotent stem cells in research and therapy , 2012, Nature.

[121]  Hideyuki Okano,et al.  Variation in the safety of induced pluripotent stem cell lines , 2009, Nature Biotechnology.

[122]  Dong Wook Han,et al.  Generation of induced pluripotent stem cells using recombinant proteins. , 2009, Cell stem cell.

[123]  E. Moss,et al.  Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. , 2002, Developmental biology.

[124]  Athanasios Stergiopoulos,et al.  Nuclear receptor NR5A2 controls neural stem cell fate decisions during development , 2016, Nature Communications.

[125]  Alice E. Chen,et al.  Reprogramming within hours following nuclear transfer into mouse but not human zygotes. , 2011, Nature communications.

[126]  G. Wahl,et al.  Linking the p53 tumor suppressor pathway to somatic cell reprogramming , 2009, Nature.

[127]  H. Sugiyama,et al.  A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts , 2012, Scientific Reports.

[128]  I. Wilmut,et al.  Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. , 2008, Experimental cell research.

[129]  J. Seelig,et al.  The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence. , 2005, Biochemistry.

[130]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[131]  R. Lovell-Badge,et al.  Multipotent cell lineages in early mouse development depend on SOX2 function. , 2003, Genes & development.

[132]  Hidenori Akutsu,et al.  A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. , 2009, Cell stem cell.

[133]  Maikun Teng,et al.  MicroRNA Cluster 302–367 Enhances Somatic Cell Reprogramming by Accelerating a Mesenchymal-to-Epithelial Transition* , 2011, The Journal of Biological Chemistry.

[134]  T. Elsdale,et al.  Sexually Mature Individuals of Xenopus laevis from the Transplantation of Single Somatic Nuclei , 1958, Nature.

[135]  Ayellet V. Segrè,et al.  The Lin28/let-7 Axis Regulates Glucose Metabolism , 2011, Cell.

[136]  Robert L. Judson,et al.  microRNA control of mouse and human pluripotent stem cell behavior. , 2013, Annual review of cell and developmental biology.

[137]  R. Deberardinis,et al.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.

[138]  S. Moon,et al.  Human embryonic stem cells express a unique set of microRNAs. , 2004, Developmental biology.

[139]  Yang Yang,et al.  Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression* , 2010, The Journal of Biological Chemistry.

[140]  M. Destrempes,et al.  Production of goats by somatic cell nuclear transfer , 1999, Nature Biotechnology.

[141]  Wenbo Zhou,et al.  Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells , 2009, Stem cells.

[142]  P. Krebsbach,et al.  DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover , 2016, Stem cells.

[143]  Hong Wang,et al.  Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation , 2017, Stem cell reports.

[144]  Robert L. Judson,et al.  Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells , 2011, Nature Biotechnology.

[145]  R. Stewart,et al.  Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences , 2009, Science.

[146]  J. Utikal,et al.  Immortalization eliminates a roadblock during cellular reprogramming into iPS cells , 2009, Nature.

[147]  M. Kuo,et al.  Function and regulation of let-7 family microRNAs. , 2012, MicroRNA.

[148]  Christian A. Ross,et al.  LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. , 2016, Cell stem cell.

[149]  Kejin Hu Vectorology and factor delivery in induced pluripotent stem cell reprogramming. , 2014, Stem cells and development.

[150]  Ryan D. Morin,et al.  Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. , 2008, Genome research.

[151]  R. Guérois,et al.  Structural basis for the interaction of Asf1 with histone H3 and its functional implications , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[152]  E. Moss,et al.  Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. , 2003, Developmental biology.

[153]  K. Hochedlinger,et al.  Chromatin dynamics during cellular reprogramming , 2013, Nature.

[154]  R. Stewart,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[155]  C. Bradshaw,et al.  Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming , 2014, Molecular cell.

[156]  Ariberto Fassati,et al.  HIV infection of non-dividing cells: a divisive problem , 2006, Retrovirology.

[157]  Stuart Thomson,et al.  MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14 , 2003, The EMBO journal.

[158]  Kavitha T. Kuppusamy,et al.  Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency. , 2014, Cell stem cell.

[159]  F. Real,et al.  Interaction between Hhex and SOX13 Modulates Wnt/TCF Activity , 2009, The Journal of Biological Chemistry.

[160]  Kazuki Takahashi,et al.  Effects of downregulating GLIS1 transcript on preimplantation development and gene expression of bovine embryos , 2015, The Journal of reproduction and development.

[161]  P. Knoepfler,et al.  Inducing iPSCs to escape the dish. , 2011, Cell stem cell.

[162]  Jeroen S. van Zon,et al.  Direct cell reprogramming is a stochastic process amenable to acceleration , 2009, Nature.

[163]  Qi Zhou,et al.  Brief Report: Combined Chemical Treatment Enables Oct4‐Induced Reprogramming from Mouse Embryonic Fibroblasts , 2011, Stem cells.

[164]  S. Orkin,et al.  An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells , 2008, Cell.

[165]  Maurizio Zuccotti,et al.  Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei , 1998, Nature.

[166]  J. I. Izpisúa Belmonte,et al.  Mitochondrial regulation in pluripotent stem cells. , 2013, Cell metabolism.

[167]  Z. Ge,et al.  Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia , 2015, PloS one.

[168]  Chun-Hyung Kim,et al.  Purification of functional reprogramming factors in mammalian cell using FLAG -Tag. , 2017, Biochemical and biophysical research communications.

[169]  Yasuko Matsumura,et al.  A more efficient method to generate integration-free human iPS cells , 2011, Nature Methods.

[170]  Weiqi Zhang,et al.  Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules , 2011, Cell Research.

[171]  V. Ambros,et al.  The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA , 1997, Cell.

[172]  Herbert Schulz,et al.  Novel STAT3 Target Genes Exert Distinct Roles in the Inhibition of Mesoderm and Endoderm Differentiation in Cooperation with Nanog , 2009, Stem cells.

[173]  Mitsugu Sekimoto,et al.  Reprogramming of mouse and human cells to pluripotency using mature microRNAs. , 2011, Cell stem cell.

[174]  M. Pirity,et al.  Generation of mouse induced pluripotent stem cells by protein transduction. , 2014, Tissue engineering. Part C, Methods.

[175]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[176]  Shinya Yamanaka,et al.  Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors , 2008, Science.

[177]  H. Ruohola-Baker,et al.  Metabolic RemodeLIN of Pluripotency. , 2016, Cell stem cell.

[178]  Mudit Gupta,et al.  Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. , 2011, Cell stem cell.

[179]  J. Nichols,et al.  Nanog safeguards pluripotency and mediates germline development , 2007, Nature.

[180]  Philippe Collas,et al.  Reprogramming fibroblasts to express T-cell functions using cell extracts , 2002, Nature Biotechnology.

[181]  H. Schöler,et al.  Molecular Obstacles to Clinical Translation of iPSCs. , 2016, Cell stem cell.

[182]  S. Kliewer,et al.  Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development , 2005, Molecular and Cellular Biology.

[183]  M. Thier,et al.  Exploring refined conditions for reprogramming cells by recombinant Oct4 protein. , 2010, The International journal of developmental biology.

[184]  Ge Guo,et al.  Nanog Is the Gateway to the Pluripotent Ground State , 2009, Cell.

[185]  A. Miller,et al.  Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection , 1990, Molecular and cellular biology.

[186]  Kristi A. Hohenstein,et al.  Regulation of Self‐Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells , 2008, Stem cells.

[187]  Jie Chen,et al.  Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation , 2013, Proceedings of the National Academy of Sciences.

[188]  S. Yamanaka,et al.  A decade of transcription factor-mediated reprogramming to pluripotency , 2016, Nature Reviews Molecular Cell Biology.

[189]  Li Zhong,et al.  Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. , 2005, Blood.

[190]  P. Knoepfler Why myc? An unexpected ingredient in the stem cell cocktail. , 2008, Cell stem cell.

[191]  Yuriy L Orlov,et al.  The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. , 2010, Cell stem cell.

[192]  Kwang-Soo Kim,et al.  Obox4 regulates the expression of histone family genes and promotes differentiation of mouse embryonic stem cells , 2010, FEBS letters.

[193]  W. Walther,et al.  Viral Vectors for Gene Transfer , 2012, Drugs.

[194]  I. Wilmut,et al.  "Viable Offspring Derived from Fetal and Adult Mammalian Cells" (1997), by Ian Wilmut et al. , 2014 .

[195]  J. Wong,et al.  Reprogramming of somatic cells via TAT-mediated protein transduction of recombinant factors. , 2012, Biomaterials.

[196]  Kit T. Rodolfa,et al.  Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. , 2010, Genes & development.

[197]  H. Schöler,et al.  Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation , 1998, Mechanisms of Development.

[198]  N. D. Clarke,et al.  Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells , 2008, Cell.

[199]  H. Schöler,et al.  Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 , 1998, Cell.

[200]  Sheng Ding,et al.  Reprogramming of human primary somatic cells by OCT4 and chemical compounds. , 2010, Cell stem cell.

[201]  Hoon-Chul Kang,et al.  Direct Reprogramming of Rat Neural Precursor Cells and Fibroblasts into Pluripotent Stem Cells , 2010, PloS one.

[202]  Zhonghan Li,et al.  Small RNA-mediated regulation of iPS cell generation , 2011, The EMBO journal.

[203]  D. Bredt,et al.  Tat protein from human immunodeficiency virus forms a metal-linked dimer. , 1988, Science.

[204]  Yifan Dai,et al.  Cloned pigs produced by nuclear transfer from adult somatic cells , 2000, Nature.

[205]  Juan Carlos Izpisua Belmonte,et al.  A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity , 2011, Current Biology.

[206]  Jennifer Nichols,et al.  Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition , 2008, PLoS biology.