Computational Astrocyence: Astrocytes encode inhibitory activity into the frequency and spatial extent of their calcium elevations

Deciphering the complex interactions between neurotransmission and astrocytic Ca2+ elevations is a target promising a comprehensive understanding of brain function. While the astrocytic response to excitatory synaptic activity has been extensively studied, how inhibitory activity results to intracellular Ca2+ waves remains elusive. In this study, we developed a compartmental astrocytic model that exhibits distinct levels of responsiveness to inhibitory activity. Our model suggested that the astrocytic coverage of inhibitory terminals defines the spatial and temporal scale of their Ca2+ elevations. Understanding the interplay between the synaptic pathways and the astrocytic responses will help us identify how astrocytes work independently and cooperatively with neurons, in health and disease.

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