Improving the accuracy of cardiac DTI by averaging the complex data

Background When performing cardiac diffusion tensor imaging (cDTI) multiple averages are typically acquired to compensate for the low signal to noise ratio of the individual images. However, the potential for reducing noise in low signal areas is not fully realized when the averaging is performed on the magnitude data[1]. Averaging the complex cDTI data is not straightforward as the diffusion weighting introduces a different, spatially varying phase across each image. In this work we use simulations to demonstrate the benefits available when using complex averaging and then develop an algorithm for performing complex averaging of in-vivo cDTI data, which accounts for the induced phase variations.