论文信息 - Mcl-1: the 1 in CLL.

Mcl-1: the 1 in CLL.

Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood , Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease

Lisa S. Chen | V. Gandhi | Lisa S Chen | K. Balakrishnan

[1] M. Keating,et al. Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. , 2008, Blood.

[2] S. Korsmeyer,et al. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. , 2008, Blood.

[3] D. Green,et al. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. , 2006, Molecular cell.

[4] T. Kipps,et al. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. , 2006, Blood.

[5] W. Plunkett,et al. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. , 2005, Blood.

[6] John Calvin Reed,et al. Apoptosis-based therapies for hematologic malignancies. , 2005, Blood.

[7] S. Korsmeyer,et al. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 , 2003, Nature.

[8] C. Croce,et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. , 1998, Blood.