Identification of Small Molecule Inhibitors of β-Amyloid Cytotoxicity through a Cell-Based High-Throughput Screening Platform
暂无分享,去创建一个
Marcie A. Glicksman | M. Michaelis | K. Seyb | M. Glicksman | Jake Ni | Kathleen Seyb | Eli R. Schuman | Mickey Huang | M. L. Michaelis | E. Schuman | J. Ni | M. Huang
[1] K. Ishiguro,et al. Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25* , 2000, The Journal of Biological Chemistry.
[2] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[3] J. Durr,et al. Possible role of calpain in normal processing of beta-amyloid precursor protein in human platelets. , 2000, Biochemical and biophysical research communications.
[4] Adriana B Ferreira,et al. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. , 2005, The Journal of biological chemistry.
[5] A. Kakita,et al. Calpain‐mediated degradation of p35 to p25 in postmortem human and rat brains , 2001, FEBS letters.
[6] M. Fehlings,et al. Pretreatment with Calpain Inhibitor CEP‐4143 Inhibits Calpain I Activation and Cytoskeletal Degradation, Improves Neurological Function, and Enhances Axonal Survival After Traumatic Spinal Cord Injury , 2000, Journal of neurochemistry.
[7] L. Villa-komaroff,et al. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. , 1989, Science.
[8] B. Stoica,et al. Caspase Inhibitor z-DEVD-fmk Attenuates Calpain and Necrotic Cell Death in Vitro and after Traumatic Brain Injury , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[9] E. Shaw. Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases. , 1994, Methods in enzymology.
[10] Yuhui Liu,et al. Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells , 2000, Journal of neurochemistry.
[11] L. Tsai,et al. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 , 1994, Nature.
[12] David S. Park,et al. Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease , 2003, The Journal of Neuroscience.
[13] R. Maccioni,et al. Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death , 1999, FEBS letters.
[14] C. Cotman,et al. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. , 1991, Brain research.
[15] L. Tsai,et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration , 1999, Nature.
[16] Carl W. Cotman,et al. In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity , 1991, Brain Research.
[17] R. Dobrowsky,et al. Stabilization of the cyclin‐dependent kinase 5 activator, p35, by paclitaxel decreases β‐amyloid toxicity in cortical neurons , 2003, Journal of neurochemistry.
[18] E. Lunney,et al. Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors. , 1996, Advances in experimental medicine and biology.
[19] A. Clark,et al. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain , 1999, Neuroscience Research.
[20] I. Donkor. A survey of calpain inhibitors. , 2000, Current medicinal chemistry.
[21] J Kerby,et al. Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis. , 2001, Analytical biochemistry.
[22] M. Mattson,et al. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[23] Lin Chen,et al. Evaluation of β-amyloid peptide 25–35 on calcium homeostasis in cultured rat dorsal root ganglion neurons , 2002, Brain Research.
[24] J. Card,et al. Proteolytic processing of beta-amyloid precursor by calpain I , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[25] Z. Zhou,et al. Evaluation of b-amyloid peptide 25 – 35 on calcium homeostasis in cultured rat dorsal root ganglion neurons , 2002 .
[26] Leslie Wilson,et al. Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. , 2005, Biochimica et biophysica acta.
[27] R. Nixon,et al. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[28] B. Yankner. Mechanisms of Neuronal Degeneration in Alzheimer's Disease , 1996, Neuron.
[29] L. Tsai,et al. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. , 2000, Journal of cell science.
[30] L. Tsai,et al. Neurotoxicity induces cleavage of p35 to p25 by calpain , 2000, Nature.
[31] L. DeLucas,et al. Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding , 1997, Nature Structural Biology.