Phenotypic plasticity and the epigenetics of human disease

[1]  C. Epstein,et al.  Inborn errors of development : the molecular basis of clinical disorders of morphogenesis , 2016 .

[2]  H. Sültmann,et al.  The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. , 2007, Cancer research.

[3]  O. Gangisetty,et al.  Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. , 2006, Genes & development.

[4]  Q. Lu,et al.  Epigenetics, disease, and therapeutic interventions , 2006, Ageing Research Reviews.

[5]  G. Mack Epigenetic cancer therapy makes headway. , 2006, Journal of the National Cancer Institute.

[6]  T. Golub,et al.  Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 , 2006, Nature.

[7]  A. Fraser,et al.  Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways , 2006, Nature Genetics.

[8]  J. Zeitlinger,et al.  Polycomb complexes repress developmental regulators in murine embryonic stem cells , 2006, Nature.

[9]  S. Méresse,et al.  Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Clare Stirzaker,et al.  Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band , 2006, Nature Genetics.

[11]  James A. Cuff,et al.  A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells , 2006, Cell.

[12]  A. Feinberg,et al.  The emerging science of epigenomics. , 2006, Human molecular genetics.

[13]  A. Berchuck,et al.  Frequent IGF2/H19 Domain Epigenetic Alterations and Elevated IGF2 Expression in Epithelial Ovarian Cancer , 2006, Molecular Cancer Research.

[14]  R. Waterland,et al.  Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. , 2006, Human molecular genetics.

[15]  B. Horsthemke,et al.  Imprinting defects on human chromosome 15 , 2006, Cytogenetic and Genome Research.

[16]  S. Zaina,et al.  Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. , 2006, Cancer research.

[17]  Luyang Sun,et al.  Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis , 2005, Nature.

[18]  H. Kantarjian,et al.  Clinical experience with decitabine in North American patients with myelodysplastic syndrome , 2005, Annals of Hematology.

[19]  D. Grier,et al.  Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells. , 2005, Cancer research.

[20]  R. Jaenisch,et al.  Global loss of imprinting leads to widespread tumorigenesis in adult mice. , 2005, Cancer cell.

[21]  R. Jaenisch,et al.  Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Jun Yao,et al.  Distinct epigenetic changes in the stromal cells of breast cancers , 2005, Nature Genetics.

[23]  S. Sait,et al.  Alternative mechanisms associated with silencing of CDKN1C in Beckwith–Wiedemann syndrome , 2005, Journal of Medical Genetics.

[24]  T. Spector,et al.  Epigenetic differences arise during the lifetime of monozygotic twins. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  W. Lam,et al.  Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells , 2005, Nature Genetics.

[26]  K. Iwamoto,et al.  Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders , 2005, Molecular Psychiatry.

[27]  Michael K. Skinner,et al.  Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility , 2005, Science.

[28]  Adam S. Raefski,et al.  Identification of a cluster of X-linked imprinted genes in mice. , 2005 .

[29]  A. Ferguson-Smith,et al.  Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour , 2005, British Journal of Cancer.

[30]  A. Feinberg,et al.  Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice , 2005, Science.

[31]  M. Fraga,et al.  Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer , 2005, Nature Genetics.

[32]  A. Feinberg,et al.  Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome. , 2004, American journal of human genetics.

[33]  James B. Mitchell,et al.  Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. , 2004, Cancer cell.

[34]  E. Li,et al.  Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells. , 2004, Genome research.

[35]  E. Giovannucci Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. , 2004, The Journal of nutrition.

[36]  Maria Vernucci,et al.  Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome , 2004, Nature Genetics.

[37]  Andrew P Feinberg,et al.  An integrated epigenetic and genetic approach to common human disease. , 2004, Trends in genetics : TIG.

[38]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[39]  Rudolf Jaenisch,et al.  Reprogramming of a melanoma genome by nuclear transplantation. , 2004, Genes & development.

[40]  C. Caldas,et al.  p300/CBP and cancer , 2004, Oncogene.

[41]  A. Feinberg,et al.  Epigenetics and assisted reproductive technology: a call for investigation. , 2004, American journal of human genetics.

[42]  M. Milili,et al.  Defective B-cell-negative selection and terminal differentiation in the ICF syndrome. , 2004, Blood.

[43]  A. Schatzkin,et al.  Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women. , 2004, Journal of the National Cancer Institute.

[44]  Stephan Eliez,et al.  Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism. , 2004, The American journal of psychiatry.

[45]  A. Feinberg,et al.  The history of cancer epigenetics , 2004, Nature Reviews Cancer.

[46]  B. Richardson DNA methylation and autoimmune disease. , 2003, Clinical immunology.

[47]  Robert A. Waterland,et al.  Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation , 2003, Molecular and Cellular Biology.

[48]  R. Bast,et al.  Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. , 2003, Cancer research.

[49]  D. Botstein,et al.  Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12 , 2003, Molecular Psychiatry.

[50]  R. Jaenisch,et al.  Chromosomal Instability and Tumors Promoted by DNA Hypomethylation , 2003, Science.

[51]  R. Jaenisch,et al.  Induction of Tumors in Mice by Genomic Hypomethylation , 2003, Science.

[52]  Manel Esteller,et al.  Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. , 2003, Cancer research.

[53]  A. Feinberg,et al.  Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk , 2003, Science.

[54]  Max Costa,et al.  Epigenetics and the Environment , 2003, Annals of the New York Academy of Sciences.

[55]  J. Herman,et al.  Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors , 2003, Nature Genetics.

[56]  L. Speybroeck From Epigenesis to Epigenetics , 2002 .

[57]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[58]  Peter A. Jones,et al.  The fundamental role of epigenetic events in cancer , 2002, Nature Reviews Genetics.

[59]  Y. Fukushima,et al.  Haploinsufficiency of NSD1 causes Sotos syndrome , 2002, Nature Genetics.

[60]  Andrew P Feinberg,et al.  Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. , 2002, American journal of human genetics.

[61]  A. Feinberg,et al.  Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. , 2001, Journal of the National Cancer Institute.

[62]  E. Selker,et al.  A histone H3 methyltransferase controls DNA methylation in Neurospora crassa , 2001, Nature.

[63]  M. Guenther,et al.  Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.

[64]  J. Herman,et al.  A gene hypermethylation profile of human cancer. , 2001, Cancer research.

[65]  Axel Benner,et al.  Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q. , 2001, Human molecular genetics.

[66]  M. Lalande Imprints of disease at GNAS1. , 2001, The Journal of clinical investigation.

[67]  D. Higgs,et al.  Molecular-clinical spectrum of the ATR-X syndrome. , 2000, American journal of medical genetics.

[68]  M. Caligiuri,et al.  Aberrant CpG-island methylation has non-random and tumour-type–specific patterns , 2000, Nature Genetics.

[69]  N. Tommerup,et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.

[70]  N. Miller,et al.  Frequent loss of imprinting of PEG1/MEST in invasive breast cancer. , 1999, Cancer research.

[71]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[72]  J. Herman,et al.  CpG island methylator phenotype in colorectal cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[73]  S. Lindquist,et al.  Hsp90 as a capacitor for morphological evolution , 1998, Nature.

[74]  A. Feinberg,et al.  Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability , 1998, Nature Medicine.

[75]  J. Foekens,et al.  Loss of imprinting of IGF2 and not H19 in breast cancer, adjacent normal tissue and derived fibroblast cultures , 1998, FEBS letters.

[76]  L. Kasturi,et al.  Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[77]  Olivier Delattre,et al.  Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer , 1998, Nature.

[78]  O. Rozenblatt-Rosen,et al.  The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[79]  M. Tucker,et al.  Risk of cancer during the first four years of life in children from The Beckwith-Wiedemann Syndrome Registry. , 1998, The Journal of pediatrics.

[80]  P. A. Jacobs,et al.  Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function , 1997, Nature.

[81]  T. Ono,et al.  IGF2 but not H19 shows loss of imprinting in human glioma. , 1996, Cancer research.

[82]  Raoul C. M. Hennekam,et al.  Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP , 1995, Nature.

[83]  R. Weinberg,et al.  Suppression of intestinal neoplasia by DNA hypomethylation , 1995, Cell.

[84]  R. Ueda,et al.  Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers. , 1995, Oncogene.

[85]  A. Bailey,et al.  Autism as a strongly genetic disorder: evidence from a British twin study , 1995, Psychological Medicine.

[86]  E. Amento,et al.  Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. , 1993, The Journal of clinical investigation.

[87]  A. Feinberg Genomic imprinting and gene activation in cancer , 1993, Nature Genetics.

[88]  A. Feinberg,et al.  Relaxation of imprinted genes in human cancer , 1993, Nature.

[89]  M. Eccles,et al.  Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour , 1993, Nature.

[90]  C. Sapienza,et al.  A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting , 1989 .

[91]  B. Horsthemke,et al.  Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma , 1989, Human Genetics.

[92]  P. Rigby,et al.  Activation of mouse genes in transformed cells , 1983, Cell.

[93]  A. Feinberg,et al.  Hypomethylation distinguishes genes of some human cancers from their normal counterparts , 1983, Nature.

[94]  P. Molloy,et al.  DNA hypomethylation and human diseases. , 2007, Biochimica et biophysica acta.

[95]  A. Feinberg,et al.  The epigenetic progenitor origin of human cancer , 2006, Nature Reviews Genetics.

[96]  S. Zaina,et al.  Soluble IGF 2 Receptor Rescues ApcMin / + Intestinal Adenoma Progression Induced by Igf 2 Loss of Imprinting , 2006 .

[97]  J. Chelly,et al.  Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized , 2006, Nature Reviews Genetics.

[98]  R. Jones Identification of a cluster of X-linked imprinted genes in mice , 2005, Nature Genetics.

[99]  P. Cole,et al.  Selective HAT inhibitors as mechanistic tools for protein acetylation. , 2004, Methods in enzymology.

[100]  J. Herman,et al.  Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. , 2003, Cancer cell.

[101]  K. Chew,et al.  Methylation of p 16 INK 4 a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia 1 , 2003 .

[102]  Andrew P Feinberg,et al.  Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. , 2003, American journal of human genetics.

[103]  Xiangyi Lu,et al.  Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution , 2003, Nature Genetics.

[104]  黒滝 直弘 私の論文から Haploinsufficiency of NSD1 causes Sotos syndrome , 2003 .

[105]  Linda Van Speybroeck From epigenesis to epigenetics: the case of C. H. Waddington. , 2002, Annals of the New York Academy of Sciences.

[106]  C. Sapienza,et al.  A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. , 1989, Proceedings of the National Academy of Sciences of the United States of America.