Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration☆
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Youqing Shen | Xuesi Chen | Dingcheng Zhu | Xiangrui Liu | Zhuxian Zhou | Xuesi Chen | Zhuxian Zhou | Xiangrui Liu | Youqing Shen | Dingcheng Zhu | Yue Wang | Zhen Zhang | Xuefei Zhou | Nasha Qiu | Nasha Qiu | Xuefei Zhou | Zhen Zhang | Yue Wang
[1] D. Scherman,et al. Intracellular fate and nuclear targeting of plasmid DNA , 1999, Cell Biology and Toxicology.
[2] I. Zuhorn,et al. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. , 2013, ACS nano.
[3] J. Lee,et al. Efficacy and mechanism of poloxamine‐assisted polyplex transfection , 2013, The journal of gene medicine.
[4] T. Bieber,et al. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. , 2002, Journal of controlled release : official journal of the Controlled Release Society.
[5] Jin-Zhi Du,et al. Sheddable ternary nanoparticles for tumor acidity-targeted siRNA delivery. , 2012, ACS nano.
[6] Shiroh Futaki,et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[7] Wade W Grabow,et al. Design and self-assembly of siRNA-functionalized RNA nanoparticles for use in automated nanomedicine , 2011, Nature Protocols.
[8] Joseph Zabner,et al. Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*) , 1995, The Journal of Biological Chemistry.
[9] D. Scherman,et al. Coupling of importin beta binding peptide on plasmid DNA: transfection efficiency is increased by modification of lipoplex's physico-chemical properties , 2003, BMC biotechnology.
[10] Jun Wang,et al. Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition. , 2016, Biomaterials.
[11] Xiang Gao,et al. Cationic liposome-mediated gene transfer. , 1995, Gene therapy.
[12] Dawen Dong,et al. PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer. , 2013, Biomaterials.
[13] Kristian Pietras,et al. High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.
[14] C. Yun,et al. A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy , 2012, Cancer Gene Therapy.
[15] J. Zia,et al. Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles. , 2003, The Biochemical journal.
[16] Xiaoyang Xu,et al. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. , 2014, Advanced drug delivery reviews.
[17] J. Rosenecker,et al. Insights into the mechanism of magnetofection using PEI‐based magnetofectins for gene transfer , 2004, The journal of gene medicine.
[18] S. Schwarze,et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. , 1999, Science.
[19] Hideyoshi Harashima,et al. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. , 2011, Advanced drug delivery reviews.
[20] Kailash C Gupta,et al. Novel polyethylenimine-derived nanoparticles for in vivo gene delivery , 2013, Expert opinion on drug delivery.
[21] Jie Chen,et al. pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers. , 2014, Journal of controlled release : official journal of the Controlled Release Society.
[22] Laura M Ensign,et al. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. , 2016, Advanced drug delivery reviews.
[23] Kevin Braeckmans,et al. The transport of nanosized gene carriers unraveled by live-cell imaging. , 2006, Angewandte Chemie.
[24] Peixuan Guo,et al. Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles. , 2017, ACS nano.
[25] Y. Anraku,et al. Monodispersed polymeric nanocapsules: spontaneous evolution and morphology transition from reducible hetero-PEG PICmicelles by controlled degradation. , 2009, Journal of the American Chemical Society.
[26] Jianping Zhou,et al. Amphoteric hyaluronic acid derivative for targeting gene delivery. , 2010, Biomaterials.
[27] M. Rhee,et al. Mechanism of Uptake of C105Y, a Novel Cell-penetrating Peptide* , 2006, Journal of Biological Chemistry.
[28] Hua Lu,et al. Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: toward nonviral gene delivery. , 2013, Angewandte Chemie.
[29] Tuo Wei,et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. , 2012, ACS nano.
[30] Efstathios Karathanasis,et al. Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles. , 2014, Nanomedicine.
[31] Ou Chen,et al. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. , 2011, Angewandte Chemie.
[32] M. Conese,et al. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[33] Yong-Eun Koo Lee,et al. Multifunctional biodegradable polyacrylamide nanocarriers for cancer theranostics--a "see and treat" strategy. , 2012, ACS nano.
[34] Erkki Ruoslahti,et al. Tumor-Penetrating Peptides , 2013, Front. Oncol..
[35] E. Wagner,et al. An acetal-based PEGylation reagent for pH-sensitive shielding of DNA polyplexes. , 2007, Bioconjugate chemistry.
[36] M. Moore,et al. Getting across the nuclear pore complex. , 1999, Trends in cell biology.
[37] A. J. Tavares,et al. Analysis of nanoparticle delivery to tumours , 2016 .
[38] H. Uludaǧ,et al. Improved transfection efficiency of an aliphatic lipid substituted 2 kDa polyethylenimine is attributed to enhanced nuclear association and uptake in rat bone marrow stromal cell , 2011, The journal of gene medicine.
[39] S. Pun,et al. HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight. , 2011, Journal of controlled release : official journal of the Controlled Release Society.
[40] Kazunori Kataoka,et al. Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery. , 2008, Angewandte Chemie.
[41] Lucas Pelkmans,et al. Endocytosis Via Caveolae , 2002, Traffic.
[42] Robert Langer,et al. A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery , 2008 .
[43] Clive J Roberts,et al. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. , 2002, Bioconjugate chemistry.
[44] Merdol Ibrahim,et al. Selective enhancement of gene transfer by steroid-mediated gene delivery , 2001, Nature Biotechnology.
[45] K. Ferrara,et al. Ultrasonic Enhancement of Drug Penetration in Solid Tumors , 2013, Front. Oncol..
[46] Robert Langer,et al. Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA , 2000 .
[47] R. Zhuo,et al. Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups. , 2010, Chemical communications.
[48] Leaf Huang,et al. Pharmacokinetics and biodistribution of nanoparticles. , 2008, Molecular pharmaceutics.
[49] Kazunori Kataoka,et al. Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)‐siRNA Conjugate Formulated in PEGylated Polyplexes , 2007, ChemMedChem.
[50] Leone Spiccia,et al. Zwitterionic-coated "stealth" nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system. , 2014, Small.
[51] D W Pack,et al. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[52] W. Flanagan,et al. A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[53] Bin Sun,et al. Release of DNA from polyelectrolyte multilayers fabricated using 'charge-shifting' cationic polymers: tunable temporal control and sequential, multi-agent release. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[54] K. Braeckmans,et al. Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[55] A. Mason,et al. Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[56] Zicai Liang,et al. Elimination pathways of systemically delivered siRNA. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.
[57] Daniel Scherman,et al. pH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.
[58] R. Macdonald,et al. Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. , 2009, Molecular pharmaceutics.
[59] Mauro Ferrari,et al. Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments. , 2014, Cancer letters.
[60] Gaurav Sahay,et al. Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers. , 2016, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.
[61] Xing-jie Liang,et al. Structural impact of graft and block copolymers based on poly(N-vinylpyrrolidone) and poly(2-dimethylaminoethyl methacrylate) in gene delivery. , 2015, Journal of materials chemistry. B.
[62] Warren C W Chan,et al. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. , 2007, Nano letters.
[63] R. Zhuo,et al. Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate. , 2011, Bioconjugate chemistry.
[64] Seungpyo Hong,et al. The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers. , 2009, Bioconjugate chemistry.
[65] Daniel G. Anderson,et al. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[66] M. Yamaizumi,et al. Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cells. , 1987, Experimental cell research.
[67] D. Putnam,et al. Design of imidazole-containing endosomolytic biopolymers for gene delivery. , 2000, Biotechnology and bioengineering.
[68] H. Okada,et al. Cytoplasm-responsive nanocarriers conjugated with a functional cell-penetrating peptide for systemic siRNA delivery. , 2013, International journal of pharmaceutics.
[69] Mengli Li,et al. Large Pore‐Sized Hollow Mesoporous Organosilica for Redox‐Responsive Gene Delivery and Synergistic Cancer Chemotherapy , 2016, Advanced materials.
[70] Jun Wang,et al. Matrix metalloproteinase 2-responsive micelle for siRNA delivery. , 2014, Biomaterials.
[71] D. Thompson,et al. Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[72] R K Jain,et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.
[73] Miss A.O. Penney. (b) , 1974, The New Yale Book of Quotations.
[74] M. Monsigny,et al. Potocytosis and Cellular Exit of Complexes as Cellular Pathways for Gene Delivery by Polycations , 2005 .
[75] Daniel G. Anderson,et al. Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters). , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[76] Shubiao Zhang,et al. The headgroup evolution of cationic lipids for gene delivery. , 2013, Bioconjugate chemistry.
[77] Takahiro Nomoto,et al. Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers , 2013 .
[78] Jeong Won Lee,et al. Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles , 2010, Clinical Cancer Research.
[79] S. Agarwal,et al. PDMAEMA based gene delivery materials , 2012 .
[80] B. Nichols. Caveosomes and endocytosis of lipid rafts , 2003, Journal of Cell Science.
[81] Yijia Zhang,et al. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. , 2015, Biomaterials.
[82] Youqing Shen,et al. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy. , 2017, Journal of materials chemistry. B.
[83] Hamidreza Ghandehari,et al. Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[84] Zhuxian Zhou,et al. Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[85] Gaurav Sahay,et al. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. , 2008, Bioconjugate chemistry.
[86] Youqing Shen,et al. Enhanced shRNA delivery and ABCG2 silencing by charge-reversible layered nanocarriers. , 2015, Small.
[87] Ernst Wagner,et al. The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[88] P. Felgner,et al. Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes. , 1996, Biochimica et biophysica acta.
[89] Ji-Ho Park,et al. Endocytosis and exocytosis of nanoparticles in mammalian cells , 2014, International journal of nanomedicine.
[90] C. Ahn,et al. Biodegradable Poly(ethylene glycol)-co-poly(l-lysine)-g-histidine Multiblock Copolymers for Nonviral Gene Delivery , 2004 .
[91] Daniel G. Anderson,et al. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. , 2003, Angewandte Chemie.
[92] Leaf Huang,et al. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. , 2006, Molecular pharmaceutics.
[93] Vladimir P Torchilin,et al. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. , 2008, Biopolymers.
[94] Xiangyang Shi,et al. Partially PEGylated dendrimer-entrapped gold nanoparticles: a promising nanoplatform for highly efficient DNA and siRNA delivery. , 2016, Journal of materials chemistry. B.
[95] Xian‐Zheng Zhang,et al. Reduction-sensitive polypeptides incorporated with nuclear localization signal sequences for enhanced gene delivery , 2012 .
[96] Nicholas Melosh,et al. Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation. , 2012, Nano letters.
[97] K. Kataoka,et al. Smart Polyion Complex Micelles for Targeted Intracellular Delivery of PEGylated Antisense Oligonucleotides Containing Acid‐Labile Linkages , 2005, Chembiochem : a European journal of chemical biology.
[98] Jean Campbell,et al. Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[99] Murali M. Yallapu,et al. PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications , 2010, Pharmaceutical Research.
[100] Chen Jiang,et al. Tumor-targeting and microenvironment-responsive smart nanoparticles for combination therapy of antiangiogenesis and apoptosis. , 2013, ACS nano.
[101] A. S. Sobolev,et al. Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines , 2015, Theranostics.
[102] Si-Shen Feng,et al. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. , 2005, Biomaterials.
[103] Su Jeong Song,et al. Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[104] T. Yamaoka,et al. Quantitative comparison between poly(L-arginine) and poly(L-lysine) at each step of polyplex-based gene transfection using a microinjection technique , 2012, Science and technology of advanced materials.
[105] Xuesi Chen,et al. Codelivery of antitumor drug and gene by a pH-sensitive charge-conversion system. , 2015, ACS applied materials & interfaces.
[106] Daniel W. Pack,et al. Design and development of polymers for gene delivery , 2005, Nature Reviews Drug Discovery.
[107] J. Leroux,et al. Activatable cell penetrating peptide-peptide nucleic acid conjugate via reduction of azobenzene PEG chains. , 2014, Journal of the American Chemical Society.
[108] P. Artursson,et al. Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo , 2001, Gene Therapy.
[109] Peixuan Guo,et al. Stable RNA nanoparticles as potential new generation drugs for cancer therapy. , 2014, Advanced drug delivery reviews.
[110] W. Saltzman,et al. Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors. , 2012, Biomaterials.
[111] J. Schlenoff. Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption , 2014, Langmuir : the ACS journal of surfaces and colloids.
[112] K. Kataoka,et al. pH-Sensitive Multi-PEGylated Block Copolymer as a Bioresponsive pDNA Delivery Vector , 2010, Pharmaceutical Research.
[113] Peixuan Guo,et al. Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA. , 2005, Human gene therapy.
[114] Wei Wu,et al. Effects of spatial distribution of the nuclear localization sequence on gene transfection in catiomer-gene polyplexes. , 2013, Journal of materials chemistry. B.
[115] I. Maclachlan,et al. Long-circulating vectors for the systemic delivery of genes. , 2001, Current opinion in molecular therapeutics.
[116] Wei Sun,et al. Chitosan-based formulations for delivery of DNA and siRNA. , 2010, Advanced drug delivery reviews.
[117] E. Wagner,et al. Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond). , 2015, Chemical reviews.
[118] Wei Wang,et al. Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence. , 2012, Biomaterials.
[119] Daniel G Anderson,et al. Electrostatic surface modifications to improve gene delivery , 2010, Expert opinion on drug delivery.
[120] C. Pichon,et al. Intracellular Availability of pDNA and mRNA after Transfection: A Comparative Study among Polyplexes, Lipoplexes, and Lipopolyplexes. , 2016, Molecular pharmaceutics.
[121] J. Rappoport,et al. Focusing on clathrin-mediated endocytosis. , 2008, The Biochemical journal.
[122] L. Kumar,et al. Exosomes: Natural Carriers for siRNA Delivery. , 2015, Current pharmaceutical design.
[123] Wilson Mok,et al. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. , 2006, Cancer research.
[124] Jie Chen,et al. Ultrasensitive pH Triggered Charge/Size Dual-Rebound Gene Delivery System. , 2016, Nano letters.
[125] Jill P. Mesirov,et al. Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4 , 2012, Science Translational Medicine.
[126] C. M. Roth,et al. Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities. , 2012, Critical reviews in biomedical engineering.
[127] Alfredo Quiñones-Hinojosa,et al. Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo , 2014, ACS nano.
[128] Omid C Farokhzad,et al. Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. , 2016, Angewandte Chemie.
[129] V. Labhasetwar,et al. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. , 2002, International journal of pharmaceutics.
[130] Wenjun Yang,et al. Disulfide cross-linked low generation dendrimers with high gene transfection efficacy, low cytotoxicity, and low cost. , 2012, Journal of the American Chemical Society.
[131] Qiang Zhang,et al. Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment , 2017, Theranostics.
[132] R. Callaghan,et al. Optimising non‐viral gene delivery in a tumour spheroid model , 2006, The journal of gene medicine.
[133] J. Lam,et al. Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems , 2012 .
[134] Maohong Fan,et al. Charge‐Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery , 2009 .
[135] Warren C W Chan,et al. Nanoparticle-mediated cellular response is size-dependent. , 2008, Nature nanotechnology.
[136] Xianghui Xu,et al. Bio-inspired supramolecular hybrid dendrimers self-assembled from low-generation peptide dendrons for highly efficient gene delivery and biological tracking. , 2014, ACS nano.
[137] K. Kataoka,et al. Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression. , 2017, Biomacromolecules.
[138] P. Cullis,et al. Drug Delivery Systems: Entering the Mainstream , 2004, Science.
[139] M. Hashida,et al. Development of gene drug delivery systems based on pharmacokinetic studies. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[140] Shi Xu,et al. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. , 2013, Advanced drug delivery reviews.
[141] P. Boisguérin,et al. Delivery of therapeutic oligonucleotides with cell penetrating peptides☆ , 2015, Advanced Drug Delivery Reviews.
[142] Xuesi Chen,et al. Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment. , 2015, Acta biomaterialia.
[143] Zhuxian Zhou,et al. Molecular imaging of the tumor microenvironment☆ , 2017, Advanced drug delivery reviews.
[144] A. F. Saleh,et al. Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[145] G. Zuber,et al. Targeted gene delivery to cancer cells: directed assembly of nanometric DNA particles coated with folic acid. , 2003, Angewandte Chemie.
[146] J. Sunshine,et al. Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cells. , 2014, Bioconjugate chemistry.
[147] Zhen Gu,et al. Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery , 2016 .
[148] D. Dean,et al. Progress and prospects: nuclear import of nonviral vectors , 2010, Gene Therapy.
[149] R. Duncan,et al. Dendrimer biocompatibility and toxicity. , 2005, Advanced drug delivery reviews.
[150] Xuesi Chen,et al. Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers , 2010 .
[151] R K Jain,et al. Transport of molecules in the tumor interstitium: a review. , 1987, Cancer research.
[152] Mark E. Davis,et al. Non-viral gene delivery systems. , 2002, Current opinion in biotechnology.
[153] M Laird Forrest,et al. pH‐Responsive Multi‐PEGylated Dual Cationic Nanoparticles Enable Charge Modulations for Safe Gene Delivery , 2007, ChemMedChem.
[154] A S Verkman,et al. Size-dependent DNA Mobility in Cytoplasm and Nucleus* , 2000, The Journal of Biological Chemistry.
[155] C. Berkland,et al. Noncovalently associated cell-penetrating peptides for gene delivery applications. , 2013, Therapeutic delivery.
[156] Terry W. J. Steele,et al. Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy , 2008, Journal of Controlled Release.
[157] Victor Frenkel,et al. Ultrasound mediated delivery of drugs and genes to solid tumors. , 2008, Advanced drug delivery reviews.
[158] Z. Gu,et al. Viral Mimicking Ternary Polyplexes: A Reduction‐Controlled Hierarchical Unpacking Vector for Gene Delivery , 2014, Advanced materials.
[159] Shu Liu,et al. Alginic Acid-Coated Chitosan Nanoparticles Loaded with Legumain DNA Vaccine: Effect against Breast Cancer in Mice , 2013, PloS one.
[160] Francis C Szoka,et al. Designing dendrimers for biological applications , 2005, Nature Biotechnology.
[161] May C Morris,et al. A non-covalent peptide-based strategy for protein and peptide nucleic acid transduction. , 2006, Biochimica et biophysica acta.
[162] K. Toh,et al. Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[163] K. Kataoka,et al. Recent progress in development of siRNA delivery vehicles for cancer therapy. , 2016, Advanced drug delivery reviews.
[164] S. Moghimi,et al. AFM visualization of sub-50nm polyplex disposition to the nuclear pore complex without compromising the integrity of the nuclear envelope. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[165] Peixuan Guo,et al. Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology. , 2016, Molecular therapy : the journal of the American Society of Gene Therapy.
[166] A. Schätzlein,et al. Dendrimers in gene delivery. , 2005, Advanced drug delivery reviews.
[167] W. Walther,et al. Vectors and strategies for nonviral cancer gene therapy , 2016, Expert opinion on biological therapy.
[168] Shiroh Futaki,et al. High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression* , 2006, Journal of Biological Chemistry.
[169] J. Rosenecker,et al. A novel transfecting peptide comprising a tetrameric nuclear localization sequence , 2003, Journal of Molecular Medicine.
[170] J. Gasiorowski,et al. Mechanisms of nuclear transport and interventions. , 2003, Advanced drug delivery reviews.
[171] Zhuxian Zhou,et al. Molecularly precise dendrimer-drug conjugates with tunable drug release for cancer therapy. , 2014, Angewandte Chemie.
[172] Wooram Park,et al. Tumor Intracellular‐Environment Responsive Materials Shielded Nano‐Complexes for Highly Efficient Light‐Triggered Gene Delivery without Cargo Gene Damage , 2015 .
[173] Jianzhu Chen,et al. A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery , 2009, Molecular pharmaceutics.
[174] R. Alemany,et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy , 2014, Gene Therapy.
[175] Charles Li,et al. Targeting Cancer Gene Therapy with Magnetic Nanoparticles , 2012, Oncotarget.
[176] D. W. Pack,et al. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. , 2003, Bioconjugate chemistry.
[177] R. Schiffelers,et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. , 2004, Nucleic acids research.
[178] E. Wagner,et al. pH-responsive shielding of non-viral gene vectors , 2006, Expert opinion on drug delivery.
[179] J. Kartenbeck,et al. Major histocompatibility complex class I molecules mediate association of SV40 with caveolae. , 1997, Molecular biology of the cell.
[180] Jiaxi Wang,et al. Cell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systems. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[181] H. Maeda,et al. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.
[182] Kozo Nakamura,et al. Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. , 2002, Biomacromolecules.
[183] Bin He,et al. Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery. , 2013, Biomaterials.
[184] Subra Suresh,et al. Size‐Dependent Endocytosis of Nanoparticles , 2009, Advanced materials.
[185] Mauro Ferrari,et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. , 2008, Nature nanotechnology.
[186] S. Kawakami,et al. Gamma-polyglutamic acid-coated vectors for effective and safe gene therapy. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[187] Sarah Cohen,et al. How viruses access the nucleus. , 2011, Biochimica et biophysica acta.
[188] Eric Pridgen,et al. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles , 2008, Molecular pharmaceutics.
[189] I. Zuhorn,et al. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. , 2004, The Biochemical journal.
[190] Zhishen Ge,et al. PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers. , 2013, Chemical communications.
[191] S. Pun,et al. Effect of polyplex morphology on cellular uptake, intracellular trafficking, and transgene expression. , 2013, ACS nano.
[192] Shaoyi Jiang,et al. Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. , 2011, Nature chemistry.
[193] Ryan M. Pearson,et al. Size and Surface Charge of Engineered Poly(amidoamine) Dendrimers Modulate Tumor Accumulation and Penetration: A Model Study Using Multicellular Tumor Spheroids. , 2016, Molecular pharmaceutics.
[194] Yuichi Yamasaki,et al. PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. , 2008, Journal of the American Chemical Society.
[195] I. Zuhorn,et al. Gene delivery by cationic lipids: in and out of an endosome. , 2007, Biochemical Society transactions.
[196] A. Logan,et al. Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery. , 2004, Bioconjugate chemistry.
[197] Y. J. Kwon. Before and after endosomal escape: roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. , 2012, Accounts of chemical research.
[198] V. Venditto,et al. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[199] Zhonggui He,et al. The endocytosis and intracellular fate of nanomedicines: Implication for rational design , 2013 .
[200] Junxiao Ye,et al. Enzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agents. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[201] C. M. Roth,et al. PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma. , 2009, Bioconjugate chemistry.
[202] Hiroyuki Mizuguchi,et al. Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex , 2007, Nucleic acids research.
[203] Shinsuke Sando,et al. A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. , 2004, Journal of the American Chemical Society.
[204] Peixuan Guo,et al. Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. , 2005, Nano letters.
[205] Erkki Ruoslahti,et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. , 2009, Cancer cell.
[206] B. Hartmann,et al. An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression , 2009, The journal of gene medicine.
[207] A. Ballangrud,et al. Binding and interstitial penetration of liposomes within avascular tumor spheroids , 2004, International journal of cancer.
[208] Xin Ming,et al. Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions , 2014, Molecular therapy. Nucleic acids.
[209] R. Jain,et al. Role of extracellular matrix assembly in interstitial transport in solid tumors. , 2000, Cancer research.
[210] A. S. Sobolev,et al. Live imaging of transgene expression in Cloudman S91 melanoma cells after polyplex-mediated gene delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[211] D. Scherman,et al. Reduction-sensitive lipopolyamines as a novel nonviral gene delivery system for modulated release of DNA with improved transgene expression. , 2000, Journal of medicinal chemistry.
[212] A. Ballangrud,et al. Engineering Lipid Vesicles of Enhanced Intratumoral Transport Capabilities: Correlating Liposome Characteristics with Penetration into Human Prostate Tumor Spheroids , 2005, Journal of liposome research.
[213] H Akita,et al. Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[214] Leaf Huang,et al. Structure and function of lipid-DNA complexes for gene delivery. , 2000, Annual review of biophysics and biomolecular structure.
[215] F. Szoka,et al. Low‐pH‐sensitive poly(ethylene glycol) (PEG)‐stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery , 2005, The journal of gene medicine.
[216] Dominic J. Glover,et al. Multifunctional protein nanocarriers for targeted nuclear gene delivery in nondividing cells , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[217] M. Hashida,et al. The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake , 1995, Pharmaceutical Research.
[218] S. B. Tiwari,et al. Long-Circulating Polymeric Nanovectors for Tumor-Selective Gene Delivery , 2005, Technology in cancer research & treatment.
[219] Alexander M. Klibanov,et al. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[220] A. Malik,et al. Size and dynamics of caveolae studied using nanoparticles in living endothelial cells. , 2009, ACS nano.
[221] Zhen Gu,et al. ATP-triggered anticancer drug delivery , 2014, Nature Communications.
[222] Chien-Chih Chiu,et al. Chemically conjugating polyethylenimine with chondroitin sulfate to promote CD44-mediated endocytosis for gene delivery. , 2013, Molecular pharmaceutics.
[223] Shaoyi Jiang,et al. Nanoparticles for drug delivery prepared from amphiphilic PLGA zwitterionic block copolymers with sharp contrast in polarity between two blocks. , 2010, Angewandte Chemie.
[224] R. Brasseur,et al. A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[225] Robert Langer,et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling , 2013, Nature Biotechnology.
[226] Christopher E. Nelson,et al. Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo. , 2013, ACS nano.
[227] M. Gottikh,et al. Physico-chemical and biological properties of antisense phosphodiester oligonucleotides with various secondary structures. , 1999, Nucleosides & nucleotides.
[228] G. Nienhaus,et al. Engineered nanoparticles interacting with cells: size matters , 2014, Journal of Nanobiotechnology.
[229] Galo J. A. A. Soler-Illia,et al. Hyaluronan degrading silica nanoparticles for skin cancer therapy. , 2013, Nanoscale.
[230] Mauro Ferrari,et al. Principles of nanoparticle design for overcoming biological barriers to drug delivery , 2015, Nature Biotechnology.
[231] Hiroshi Maeda,et al. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. , 2015, Advanced drug delivery reviews.
[232] Hua Lu,et al. Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting. , 2014, Biomaterials.
[233] Laurence Tetley,et al. Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[234] K. Leong,et al. PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. , 2006, Bioconjugate chemistry.
[235] E. Ruoslahti,et al. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration , 2009, Proceedings of the National Academy of Sciences.
[236] Kam W. Leong,et al. Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines , 2016 .
[237] A. Mikos,et al. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[238] Zhenzhong Zhang,et al. Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon , 2015, Theranostics.
[239] T. Anchordoquy,et al. Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. , 2011, Journal of pharmaceutical sciences.
[240] Daan Frenkel,et al. Receptor-mediated endocytosis of nanoparticles of various shapes. , 2011, Nano letters.
[241] Stephen J. Lee,et al. Charge-reversal amphiphiles for gene delivery. , 2004, Journal of the American Chemical Society.
[242] Paula T Hammond,et al. Highly stable, ligand-clustered "patchy" micelle nanocarriers for systemic tumor targeting. , 2010, Nanomedicine : nanotechnology, biology, and medicine.
[243] Shinobu Ueda,et al. Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.
[244] R. B. Campbell,et al. Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[245] Andrew D. Miller,et al. Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA , 2014, Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research.
[246] Dai Fukumura,et al. Multistage nanoparticle delivery system for deep penetration into tumor tissue , 2011, Proceedings of the National Academy of Sciences.
[247] A. Moursi,et al. Long-term efficient gene delivery using polyethylenimine with modified Tat peptide. , 2014, Biomaterials.
[248] P. Nicotera,et al. Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis , 1997, The Journal of experimental medicine.
[249] Y. Okahata,et al. Mechanism of cell transfection with plasmid/chitosan complexes. , 2001, Biochimica et biophysica acta.
[250] S. Pun,et al. Increased nanoparticle penetration in collagenase-treated multicellular spheroids , 2007, International journal of nanomedicine.
[251] Nicholas A Peppas,et al. A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[252] Daniel S. Kohane,et al. Photoswitchable nanoparticles for in vivo cancer chemotherapy , 2013, Proceedings of the National Academy of Sciences.
[253] D. Discher,et al. Shape effects of filaments versus spherical particles in flow and drug delivery. , 2007, Nature nanotechnology.
[254] Chen Jiang,et al. Tumor targeting and microenvironment-responsive nanoparticles for gene delivery. , 2013, Biomaterials.
[255] Athena W Wong,et al. DNA Internalized via Caveolae Requires Microtubule-dependent, Rab7-independent Transport to the Late Endocytic Pathway for Delivery to the Nucleus* , 2007, Journal of Biological Chemistry.
[256] S. Kawakami,et al. The development of a gene vector electrostatically assembled with a polysaccharide capsule. , 2009, Biomaterials.
[257] Jinchao Zhang,et al. Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors. , 2013, Cancer research.
[258] Y. Okahata,et al. Optimization of nuclear localization signal for nuclear transport of DNA-encapsulating particles. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[259] Zhuxian Zhou,et al. Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery. , 2016, Biomaterials science.
[260] M. Elbaum,et al. Correlation between cationic lipid-based transfection and cell division. , 2016, Experimental cell research.
[261] R. Zhuo,et al. Disulfide cross-linked polyethylenimines (PEI) prepared via thiolation of low molecular weight PEI as highly efficient gene vectors. , 2008, Bioconjugate chemistry.
[262] Dai Fukumura,et al. Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model , 2012, Annals of Biomedical Engineering.
[263] Zicai Liang,et al. pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release. , 2016, Nano letters.
[264] S Moein Moghimi,et al. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[265] C. Sirlin,et al. Gene transfer with a series of lipophilic DNA-binding molecules. , 1994, Bioconjugate chemistry.
[266] Anna Moore,et al. In vivo imaging of siRNA delivery and silencing in tumors , 2007, Nature Medicine.
[267] I. Wistuba,et al. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment , 2015, Proceedings of the National Academy of Sciences.
[268] F. Leung,et al. Enhanced gene delivery by chitosan-disulfide-conjugated LMW-PEI for facilitating osteogenic differentiation. , 2013, Acta biomaterialia.
[269] A. Ristimäki,et al. Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development , 2011, Cancer Gene Therapy.
[270] R. Jain. Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.
[271] H. Azzazy,et al. Chitosan Nanoparticles for Nuclear Targeting: The Effect of Nanoparticle Size and Nuclear Localization Sequence Density. , 2015, Molecular pharmaceutics.
[272] Moonjung Choi,et al. Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality. , 2010, ACS nano.
[273] T Salditt,et al. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. , 1998, Science.
[274] R. Martuza,et al. Oncolytic viral therapies – the clinical experience , 2005, Oncogene.
[275] Erkki Ruoslahti,et al. Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs , 2010, Science.
[276] R. Koynova,et al. Cationic lipids: molecular structure/ transfection activity relationships and interactions with biomembranes. , 2010, Topics in current chemistry.
[277] C. Vervaet,et al. Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking , 2011 .
[278] Takao Hayakawa,et al. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[279] H. O'brodovich,et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer , 1999, Gene Therapy.
[280] Daniel G. Anderson,et al. Non-viral vectors for gene-based therapy , 2014, Nature Reviews Genetics.
[281] K. Kinzler,et al. A nanoparticle formulation that selectively transfects metastatic tumors in mice , 2013, Proceedings of the National Academy of Sciences.
[282] Gary R Whittaker. Virus nuclear import. , 2003, Advanced drug delivery reviews.
[283] P. Delvenne,et al. PEGylation of lipoplexes: The right balance between cytotoxicity and siRNA effectiveness. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[284] P. Schlag,et al. Low-volume jet injection for efficient nonviral in vivo gene transfer , 2004, Molecular biotechnology.
[285] Meiwan Chen,et al. Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery , 2016 .
[286] C Russell Middaugh,et al. Barriers to nonviral gene delivery. , 2003, Journal of pharmaceutical sciences.
[287] Jianbin Tang,et al. The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment. , 2015, ACS nano.
[288] T. Jin,et al. Uptake mechanisms of non-viral gene delivery. , 2012, Journal of Controlled Release.
[289] J. Behr,et al. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[290] C. Pichon,et al. Nuclear delivery of NFκB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging , 2008, Nucleic acids research.
[291] Bin Liu,et al. A Photoactivatable AIE Polymer for Light-Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking. , 2015, Angewandte Chemie.
[292] H. Harashima,et al. Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. , 2013, Molecular Therapy.
[293] Takeshi Ono,et al. Targeting gene therapy for prostate cancer cells by liposomes complexed with anti-prostate-specific membrane antigen monoclonal antibody. , 2006, Human gene therapy.
[294] Nupura S. Bhise,et al. A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles. , 2012, Small.
[295] C. Allen,et al. Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[296] D. Lamm,et al. DNA based therapy with diphtheria toxin-A BC-819: a phase 2b marker lesion trial in patients with intermediate risk nonmuscle invasive bladder cancer. , 2014, The Journal of urology.
[297] A. Zamyatnin,et al. Viral vectors for gene therapy: Current state and clinical perspectives , 2016, Biochemistry (Moscow).
[298] Mattias Belting,et al. Nuclear delivery of macromolecules: barriers and carriers. , 2005, Advanced drug delivery reviews.
[299] T. McIntosh,et al. Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery. , 2011, Bioconjugate chemistry.
[300] Kam W Leong,et al. Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery. , 2010, Nano today.
[301] Chad A. Mirkin,et al. Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation , 2006, Science.
[302] A. Kiss,et al. Endocytosis via caveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation? , 2009, Journal of cellular and molecular medicine.
[303] C. Pichon,et al. Histidine-rich peptides and polymers for nucleic acids delivery. , 2001, Advanced drug delivery reviews.
[304] A. Colell,et al. Mitochondrial glutathione, a key survival antioxidant. , 2009, Antioxidants & redox signaling.
[305] M. Wood,et al. Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. , 2012, Human molecular genetics.
[306] Richard N Cohen,et al. Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[307] I. Tannock,et al. Drug penetration in solid tumours , 2006, Nature Reviews Cancer.
[308] Jaroslav Pelisek,et al. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[309] L. Meinel,et al. Matrix Metalloproteinase Responsive Delivery of Myostatin Inhibitors , 2016, Pharmaceutical Research.
[310] Yaping Li,et al. A smart nanoassembly consisting of acid-labile vinyl ether PEG-DOPE and protamine for gene delivery: preparation and in vitro transfection. , 2008, Biomacromolecules.
[311] Triantafyllos Stylianopoulos,et al. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. , 2011, Annual review of chemical and biomolecular engineering.
[312] Qiao Jiang,et al. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. , 2010, ACS nano.
[313] Youqing Shen,et al. Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization , 2017, Advanced materials.
[314] V. Torchilin. Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.
[315] N. Nishiyama,et al. Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. , 2013, Angewandte Chemie.
[316] Xuesi Chen,et al. Production and clinical development of nanoparticles for gene delivery , 2016, Molecular therapy. Methods & clinical development.
[317] D. Fischer,et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[318] Zhuxian Zhou,et al. A linear polyethylenimine (LPEI) drug conjugate with reversible charge to overcome multidrug resistance in cancer cells , 2015 .
[319] N. Pante,et al. Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. , 2002, Molecular biology of the cell.
[320] H Akita,et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid , 2007, Gene Therapy.
[321] Leaf Huang,et al. Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[322] V. S. Lin,et al. Mesoporous silica nanoparticles deliver DNA and chemicals into plants. , 2007, Nature nanotechnology.
[323] T. Ishida,et al. Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration. , 2013, International journal of pharmaceutics.
[324] M. Cotten,et al. Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus , 2000, Gene Therapy.
[325] Shuo Li,et al. Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery. , 2015, Journal of materials chemistry. B.
[326] Shaoyi Jiang,et al. Ultralow‐Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications , 2010, Advanced materials.
[327] Kit S Lam,et al. The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. , 2011, Biomaterials.
[328] L G Griffith,et al. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes , 2005, Gene Therapy.
[329] A. Mikos,et al. Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. , 1999, Journal of biomedical materials research.
[330] Sheng-Gang Ding,et al. Self-assembling Janus dendritic polymer for gene delivery with low cytotoxicity and high gene transfection efficiency. , 2016, Journal of materials chemistry. B.
[331] Huajian Gao,et al. Mechanics of receptor-mediated endocytosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[332] R. Kumar,et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. , 1994, The Journal of biological chemistry.
[333] David Putnam,et al. Polymers for gene delivery across length scales , 2006, Nature materials.
[334] Lei Yu,et al. An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems. , 2008, Biomacromolecules.
[335] Kunn Hadinoto,et al. Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[336] Younan Xia,et al. A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells. , 2013, Angewandte Chemie.
[337] C. Morrison. $1-million price tag set for Glybera gene therapy , 2015, Nature Biotechnology.
[338] M. Uesaka,et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. , 2011, Nature nanotechnology.
[339] D. Mukhopadhyay,et al. DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis. , 2012, Nano letters.
[340] Peixuan Guo,et al. Thermodynamically Stable RNA three-way junctions as platform for constructing multi-functional nanoparticles for delivery of therapeutics , 2011, Nature Nanotechnology.
[341] K. Leong,et al. Multifunctional nanorods for gene delivery , 2003, Nature materials.
[342] T. Anchordoquy,et al. The use of fluorescence resonance energy transfer to monitor dynamic changes of lipid-DNA interactions during lipoplex formation. , 2003, Biochimica et biophysica acta.
[343] C. Vanhove,et al. In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier. , 2013, Biomaterials.
[344] S. L. Hyatt,et al. Nanoparticles of Compacted DNA Transfect Postmitotic Cells* , 2003, Journal of Biological Chemistry.
[345] Gaurav Sahay,et al. Endocytosis of nanomedicines. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[346] A. Mason,et al. Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA. , 2016, Molecular pharmaceutics.
[347] S. Azzi,et al. Vascular Permeability and Drug Delivery in Cancers , 2013, Front. Oncol..
[348] J. Dobson,et al. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery , 2006, Gene Therapy.
[349] Lin Lin,et al. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers , 2016, Polymers.
[350] R. Jain,et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[351] U. Massing,et al. Combinatorial Synthesis of New Cationic Lipids and High‐Throughput Screening of Their Transfection Properties , 2002, Chembiochem : a European journal of chemical biology.
[352] Jordan J. Green,et al. Non-viral nucleic acid containing nanoparticles as cancer therapeutics , 2016, Expert opinion on drug delivery.
[353] Mingming Wang,et al. A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios , 2014, Nature Communications.
[354] Amanda C. Engler,et al. Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection. , 2013, Biomaterials.
[355] Michael Hawkins,et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[356] K. G. Rajeev,et al. Rational design of cationic lipids for siRNA delivery , 2010, Nature Biotechnology.
[357] Yi Zhao,et al. ATP triggered drug release and DNA co-delivery systems based on ATP responsive aptamers and polyethylenimine complexes. , 2016, Journal of materials chemistry. B.
[358] Xiaojun Cai,et al. Effective gene delivery using stimulus-responsive catiomer designed with redox-sensitive disulfide and acid-labile imine linkers. , 2012, Biomacromolecules.
[359] C. K. Chan,et al. Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence. , 1999, Human gene therapy.
[360] A. Klibanov,et al. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[361] M. Ogris,et al. PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.
[362] Jessie L.-S. Au,et al. Drug Delivery and Transport to Solid Tumors , 2003, Pharmaceutical Research.
[363] K. Pärn,et al. PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[364] T. Park,et al. Hyaluronic acid-polyethyleneimine conjugate for target specific intracellular delivery of siRNA. , 2008, Biopolymers.
[365] Astrid Gräslund,et al. Mechanisms of Cellular Uptake of Cell-Penetrating Peptides , 2011, Journal of biophysics.
[366] N. Selvamurugan,et al. Chitosan and its derivatives for gene delivery. , 2011, International journal of biological macromolecules.
[367] Youqing Shen,et al. Intracellularly Disintegratable Polysulfoniums for Efficient Gene Delivery , 2017 .
[368] Samir Mitragotri,et al. Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses. , 2007, Biophysical journal.
[369] Jo Wixon,et al. Gene therapy clinical trials worldwide to 2012 – an update , 2013, The journal of gene medicine.
[370] G. Merlo,et al. Polyethylenimine-based intravenous delivery of transgenes to mouse lung , 1998, Gene Therapy.
[371] R. Jain,et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. , 2013, Cancer research.
[372] Yoshio Kobayashi,et al. Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft , 2009, Breast Cancer Research.
[373] L. Palmer,et al. Stabilized plasmid-lipid particles: construction and characterization , 1999, Gene Therapy.
[374] Yinchu Ma,et al. Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery , 2015 .
[375] Zhenyu Jin,et al. Quantitative study of effects of free cationic chains on gene transfection in different intracellular stages. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[376] Gert Storm,et al. Sheddable Coatings for Long-Circulating Nanoparticles , 2007, Pharmaceutical Research.
[377] Jianbin Tang,et al. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. , 2013, Biomaterials.
[378] Zhuxian Zhou,et al. Effects of chirality on gene delivery efficiency of polylysine , 2015, Chinese Journal of Polymer Science.
[379] Yaping Li,et al. Transferrin-mediated PEGylated nanoparticles for delivery of DNA/PLL , 2006, Nanotechnology.
[380] Jae-hwan Kim,et al. Optimization of 25 kDa linear polyethylenimine for efficient gene delivery. , 2007, Biologicals : journal of the International Association of Biological Standardization.
[381] M. Giacca,et al. Caveolae-mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[382] D. Hallahan,et al. Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix. , 2006, Nano letters.
[383] Zhuxian Zhou,et al. Esterase‐Activated Charge‐Reversal Polymer for Fibroblast‐Exempt Cancer Gene Therapy , 2016, Advanced materials.
[384] Xianzhu Yang,et al. Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery. , 2016, Biomaterials.
[385] Z. Miao,et al. The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. , 2013, Biomaterials.
[386] Xian Jun Loh,et al. Utilising inorganic nanocarriers for gene delivery. , 2016, Biomaterials science.
[387] Robert Langer,et al. Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity , 2014, Nature Communications.
[388] M. Bawendi,et al. Renal clearance of quantum dots , 2007, Nature Biotechnology.
[389] R. Langer,et al. Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery , 2012, Journal of the American Chemical Society.
[390] P. Scodeller. Extracellular Matrix Degrading Enzymes for Nanocarrier-Based Anticancer Therapy , 2016 .
[391] R. Langer,et al. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. , 2001, Journal of the American Chemical Society.
[392] Yong Wang,et al. Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery. , 2016, Chemical communications.
[393] Y. Yeo,et al. Application of polysaccharides for surface modification of nanomedicines. , 2012, Therapeutic delivery.
[394] Christopher E. Nelson,et al. Matrix Metalloproteinase Responsive, Proximity‐Activated Polymeric Nanoparticles for siRNA Delivery , 2013, Advanced functional materials.
[395] C. Fong,et al. Transfection efficiency of chitosan vectors: effect of polymer molecular weight and degree of deacetylation. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[396] Samir Mitragotri,et al. Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects. , 2010, Current pharmaceutical design.
[397] S. Lai,et al. Anti-PEG immunity: emergence, characteristics, and unaddressed questions. , 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.
[398] Wim E Hennink,et al. Biodegradable polymers as non-viral carriers for plasmid DNA delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.
[399] D. Dean,et al. Intracellular trafficking of plasmids during transfection is mediated by microtubules. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[400] D. Scherman,et al. Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes. , 1998, Biochimica et biophysica acta.
[401] Daniel W. Pack,et al. Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells. , 2008, Journal of controlled release : official journal of the Controlled Release Society.
[402] S M Moghimi,et al. Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective. , 2012, Annual review of pharmacology and toxicology.
[403] O. Ludkovski,et al. Stabilized plasmid-lipid particles for systemic gene therapy. , 2000, Gene therapy.
[404] Chih-Kuang Chen,et al. Overcoming nonviral gene delivery barriers: perspective and future. , 2013, Molecular pharmaceutics.
[405] C. Muller,et al. A phase II trial of intraperitoneal EGEN-001, an IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: a gynecologic oncology group study. , 2014, Gynecologic oncology.
[406] K. Choi,et al. Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs , 2014, ACS nano.
[407] Sarah Seifert,et al. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape , 2013, Nature Biotechnology.
[408] S. Déjean,et al. First-in-man phase 1 clinical trial of gene therapy for advanced pancreatic cancer: safety, biodistribution, and preliminary clinical findings. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.
[409] D. Oupický,et al. Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery. , 2006, Bioconjugate chemistry.
[410] T. Okano,et al. Gene expression control by temperature with thermo-responsive polymeric gene carriers. , 2000, Journal of controlled release : official journal of the Controlled Release Society.
[411] I. Khalil,et al. Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery , 2006, Pharmacological Reviews.
[412] G. Moseley,et al. The efficiency of nuclear plasmid DNA delivery is a critical determinant of transgene expression at the single cell level , 2010, The journal of gene medicine.
[413] Pan‐Chyr Yang,et al. Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour , 2015, Nature Communications.
[414] G. Wilson,et al. Nuclear Import of Plasmid DNA in Digitonin-permeabilized Cells Requires Both Cytoplasmic Factors and Specific DNA Sequences* , 1999, The Journal of Biological Chemistry.
[415] Dai Fukumura,et al. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. , 2007, Microvascular research.
[416] Vladimir P Torchilin,et al. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. , 2002, Cancer research.
[417] Youqing Shen,et al. Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs , 2014, Advanced materials.
[418] B. Dalby,et al. Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications. , 2004, Methods.
[419] Clive J Roberts,et al. Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I. , 2003, Nucleic acids research.
[420] K. Mislick,et al. Evidence for the role of proteoglycans in cation-mediated gene transfer. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[421] R. Langer,et al. Polyhistidine-PEG:DNA nanocomposites for gene delivery. , 2003, Biomaterials.
[422] K. Ewert,et al. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content , 2014, The journal of gene medicine.
[423] J. Holthuis,et al. Lipid traffic: floppy drives and a superhighway , 2005, Nature Reviews Molecular Cell Biology.
[424] P. Wakeley,et al. Synthesis , 2013, The Role of Animals in Emerging Viral Diseases.
[425] Stephanie E. A. Gratton,et al. The effect of particle design on cellular internalization pathways , 2008, Proceedings of the National Academy of Sciences.
[426] H. Mao,et al. Simulation and Experimental Assembly of DNA-Graft Copolymer Micelles with Controlled Morphology. , 2015, ACS biomaterials science & engineering.
[427] Nobuhiro Nishiyama,et al. Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses. , 2012, Chemical Society reviews.
[428] Rakesh K. Jain,et al. Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors , 2004, Cancer Research.
[429] D. Escande,et al. Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells* , 1998, The Journal of Biological Chemistry.
[430] Y. Aoyama,et al. Remarkably size-regulated cell invasion by artificial viruses. Saccharide-dependent self-aggregation of glycoviruses and its consequences in glycoviral gene delivery. , 2003, Journal of the American Chemical Society.
[431] Maohong Fan,et al. Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. , 2010, Nanomedicine.
[432] S. Shinkai,et al. Enhanced nuclear import and transfection efficiency of plasmid DNA using streptavidin-fused importin-beta. , 2005, Journal of Controlled Release.
[433] Fei Wang,et al. Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery. , 2012, Angewandte Chemie.
[434] Yong Wang,et al. A Reduction and pH Dual‐Sensitive Polymeric Vector for Long‐Circulating and Tumor‐Targeted siRNA Delivery , 2014, Advanced materials.
[435] H. Maeda,et al. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. , 2013, Advanced drug delivery reviews.
[436] W. A. Yeudall,et al. PEGylated polyamidoamine dendrimers with bis-aryl hydrazone linkages for enhanced gene delivery. , 2010, Biomacromolecules.
[437] Charles H Jones,et al. Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors. , 2016, Trends in biotechnology.
[438] Mauro Ferrari,et al. Multi-stage delivery nano-particle systems for therapeutic applications. , 2011, Biochimica et biophysica acta.
[439] Hao Cheng,et al. Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy. , 2016, Nano letters.
[440] R. Jain,et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner , 2012, Nature nanotechnology.
[441] David V Schaffer,et al. Viral Vectors for Gene Therapy: Translational and Clinical Outlook. , 2015, Annual review of biomedical engineering.
[442] Mauro Giacca,et al. Virus-mediated gene delivery for human gene therapy. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[443] E. Wagner,et al. Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application , 2001, Gene Therapy.
[444] Bo Zhang,et al. Acid-active cell-penetrating peptides for in vivo tumor-targeted drug delivery. , 2013, Journal of the American Chemical Society.
[445] Efstathios Karathanasis,et al. The effects of particle size, density and shape on margination of nanoparticles in microcirculation , 2011, Nanotechnology.
[446] M. Ogris,et al. Polylysine-based transfection systems utilizing receptor-mediated delivery. , 1998, Advanced drug delivery reviews.
[447] Jung-Ki Park,et al. Effect of polyethylene glycol on gene delivery of polyethylenimine. , 2003, Biological & pharmaceutical bulletin.
[448] Jianbin Tang,et al. Fusogenic Reactive Oxygen Species Triggered Charge‐Reversal Vector for Effective Gene Delivery , 2016, Advanced materials.
[449] Freya Q. Schafer,et al. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. , 2001, Free radical biology & medicine.
[450] H. McMahon,et al. Mechanisms of endocytosis. , 2009, Annual review of biochemistry.
[451] I. Zuhorn,et al. Lipoplex-mediated Transfection of Mammalian Cells Occurs through the Cholesterol-dependent Clathrin-mediated Pathway of Endocytosis* , 2002, The Journal of Biological Chemistry.
[452] Y. Zhan,et al. Targeted charge-reversal nanoparticles for nuclear drug delivery. , 2007, Angewandte Chemie.
[453] T. Ishida,et al. Application of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid delivery. , 2014, Journal of pharmaceutical sciences.
[454] Aaron M. Miller,et al. Tissue-specific and transcription factor-mediated nuclear entry of DNA. , 2009, Advanced drug delivery reviews.
[455] Judy Lieberman,et al. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown , 2015, Nature Biotechnology.
[456] Meredith A Mintzer,et al. Nonviral vectors for gene delivery. , 2009, Chemical reviews.
[457] N. Templeton,et al. Liposomes in Gene Therapy , 1996, Handbook of Nonmedical Applications of Liposomes: From Gene Delivery and Diagnostics to Ecology.
[458] Xiang-gao Meng,et al. The effect of a nuclear localization sequence on transfection efficacy of genes delivered by cobalt(II)-polybenzimidazole complexes. , 2012, Biomaterials.
[459] P. Nielsen,et al. Gene delivery by a steroid‐peptide nucleic acid conjugate , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[460] Q. Ping,et al. A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery. , 2015, Journal of the American Chemical Society.
[461] Lin Lin,et al. Polyglutamic acid based polyanionic shielding system for polycationic gene carriers , 2016, Chinese Journal of Polymer Science.
[462] W. Hennink,et al. The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery , 2006, Pharmaceutical Research.
[463] U. Greber,et al. Adenovirus endocytosis , 2003, The journal of gene medicine.
[464] F. Szoka,et al. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. , 1993, Bioconjugate chemistry.
[465] I. Maclachlan,et al. Cationic lipid-mediated transfection of cells in culture requires mitotic activity , 1999, Gene Therapy.