The highly conserved DAD1 protein involved in apoptosis is required for N‐linked glycosylation

Background: The tsBN7 cell line is one of the temperature‐sensitive mutants for cell proliferation which have been isolated from the BHK21 cell line derived from the golden hamster. It has a mutation in the DAD1 gene encoding a 12.5 kDa highly conserved protein through evolution, and enters apoptosis at the restrictive temperature due to this mutation.

[1]  T. Kunitake,et al.  Synthetic cationic amphiphiles for liposome-mediated DNA transfection. , 1990, Biochemistry international.

[2]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[3]  P. Argos,et al.  β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin , 1991, Cell.

[4]  J. Rothman,et al.  Retention of membrane proteins by the endoplasmic reticulum , 1985, The Journal of cell biology.

[5]  H. Steller.  Mechanisms and genes of cellular suicide , 1995, Science.

[6]  J. Skene,et al.  Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension , 1994, The Journal of cell biology.

[7]  M. Leist,et al.  Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis. , 1995, European journal of pharmacology.

[8]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[9]  S. Komiyama,et al.  Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells , 1993, Molecular and cellular biology.

[10]  K. Arai,et al.  SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat , 1988, Molecular and cellular biology.

[11]  A Helenius,et al.  How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum. , 1994, Molecular biology of the cell.

[12]  M. Seldin,et al.  The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11–q12 and mouse chromosome 14 and has plant and nematode homologs , 1995, FEBS letters.

[13]  S. Minakami,et al.  Fragmentation of re-formation of mitotic Golgi apparatus detected by a centrifugal method. , 1990, Experimental cell research.

[14]  P. Stanley.  Glycosylation mutants of animal cells. , 1984, Annual review of genetics.

[15]  R. Masaki,et al.  Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes? , 1985, The Journal of cell biology.

[16]  Y. Gluzman.  SV40-transformed simian cells support the replication of early SV40 mutants , 1981, Cell.

[17]  S. Shimizu,et al.  Biochemical Studies of Rat Liver Golgi Apparatus , 1978 .

[18]  S. Kawabata,et al.  Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. , 1986, Journal of biochemistry.

[19]  K. Mihara,et al.  Malfolded cytochrome P-450(M1) localized in unusual membrane structures of the endoplasmic reticulum in cultured animal cells. , 1995, Journal of biochemistry.

[20]  J. Saraste,et al.  Distribution of the intermediate elements operating in ER to Golgi transport. , 1991, Journal of cell science.

[21]  R. Freedman,et al.  The latency of rat liver microsomal protein disulphide-isomerase. , 1985, The Biochemical journal.

[22]  F. Mollinedo,et al.  Inhibition of N‐linked glycosylation induces early apoptosis in human promyelocytic HL‐60 cells , 1995, Journal of cellular physiology.

[23]  J. Rothman,et al.  dad‐1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. , 1995, The EMBO journal.

[24]  Kai Simons,et al.  The role of n-glycans in the secretory pathway , 1995, Cell.

[25]  T. Makishima,et al.  An Arabidopsis thaliana cDNA complementing a hamster apoptosis suppressor mutant. , 1997, The Plant journal : for cell and molecular biology.

[26]  Y. Seyama,et al.  Dolichyl phosphate, a potent inducer of apoptosis in rat glioma C6 cells. , 1995, Biochemical and biophysical research communications.

[27]  Y. Fujiki,et al.  Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum , 1982, The Journal of cell biology.

[28]  H. Okayama,et al.  High-efficiency transformation of mammalian cells by plasmid DNA. , 1987, Molecular and cellular biology.

[29]  D. Kelleher,et al.  The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms , 1995, The Journal of cell biology.

[30]  S. Shimizu,et al.  Biochemical studies of rat liver Golgi apparatus. I. Isolation and preliminary characterization. , 1978, Journal of biochemistry.