Squamous cell carcinoma of the tonsil and tongue-base region.

From 1969 through 1975, 145 patients were treated for squamous cell carcinoma of the tonsil and tongue-base region; 119 received initial treatment, and salvage operations were done in 26. The overall five-year survival rate was 42%. Cervical metastasis was the most important determinant of survival. Pathologic stage I or II disease was controlled by surgical treatment. In patients with stage III or IV disease, operation alone controlled the primary lesion better than radiation alone or combined preoperative radiation and surgical treatment. With operation alone, however the rate of neck recurrence was higher than with the other two methods of treatment. In advanced disease, surgical treatment combined with postoperative radiation should be considered. Mandibular osteotomy and excision of the primary lesion are as effective in local tumor control as composite resection. In patients with a tumor-free margin, osteotomy can be used to preserve the mandible.

[1]  G. Fletcher,et al.  The place of irradiation in the management of the primary lesion in head and neck cancers , 1977, Cancer.

[2]  G. Fletcher,et al.  Treatment of the neck in patients with squamous cell carcinoma of the head and neck , 1977, Cancer.

[3]  F. Cardinale,et al.  Radiation therapy of carcinoma of the tonsil , 1977, Cancer.

[4]  E. Sugarbaker,et al.  Squamous cell carcinoma of the oropharynx: why we fail. , 1976, American journal of surgery.

[5]  E. Strong,et al.  Carcinoma of the oral cavity. factors affecting treatment failure at the primary site and neck. , 1976, American journal of surgery.

[6]  G. Fletcher,et al.  Time, dose, and tumor volume relationships in irradiation of squamous cell carcinomas of the base of the tongue , 1976, Cancer.

[7]  D. Goffinet,et al.  Carcinoma of the oropharynx. Results of megavoltage radiation therapy in 305 patients. , 1976, AJR. American journal of roentgenology.

[8]  K. Fu,et al.  External and interstitial radiation therapy of carcinoma of the oral tongue. A review of 32 years' experience. , 1976, AJR. American journal of roentgenology.

[9]  D. A. Shumrick,et al.  Carcinoma of the tonsil: Results of combined therapy , 1974, The Laryngoscope.

[10]  K. D. Devine,et al.  Surgical treatment of squamous cell carcinoma of the tonsil , 1974, The Laryngoscope.

[11]  Halvor Vermund,et al.  Role of radiotherapy in the treatment of cancer of the tongue. A retrospective analysis on TNM‐staged tumors treated between 1958 and 1968 , 1973, Cancer.

[12]  H. Farr,et al.  Prognostic Significance of Histologic Grade in Epidermoid Carcinoma of the Mouth and Pharynx , 1972 .

[13]  G. Fletcher,et al.  Management of cervical lymph node metastases in squamous cell carcinoma of the tonsillar fossa, base of tongue, supraglottic larynx, and hypopharynx. , 1972, American journal of surgery.

[14]  K. D. Devine,et al.  Surgical treatment of squamous cell carcinoma of the base of the tongue. , 1972, The Laryngoscope.

[15]  C. C. Wang.  Management and prognosis of squamous-cell carcinoma of the tonsillar region. , 1972, Radiology.

[16]  L. Ackerman,et al.  Malignant tumors of the tonsil. Analysis of failures and factors affecting prognosis. , 1972, The American journal of roentgenology, radium therapy, and nuclear medicine.

[17]  J. Murphy,et al.  The periosteum of the mandible and intraoral carcinoma. , 1971, American journal of surgery.

[18]  R. Thompson,et al.  Elective irradiation of the neck in patients with primary carcinoma of the head and neck. , 1971, JAMA.

[19]  J. Fayos,et al.  Radiation therapy of carcinoma of the tonsillar region. , 1971, The American journal of roentgenology, radium therapy, and nuclear medicine.

[20]  C. Perez,et al.  Carcinoma of the tonsil: sequential comparison of four treatment modalities. , 1970, Radiology.

[21]  C. Harrold.  Surgical treatment of cancer of the base of the tongue. , 1967, American journal of surgery.

[22]  F. Hoffmeister,et al.  Carcinoma of the tonsil. Comparison of surgical and radiation therapy. , 1967, American journal of surgery.

[23]  Farr Hw,et al.  Carcinoma of the tonsillar fossa. , 1967 .

[24]  G. Fletcher,et al.  Squamous cell carcinomas of the tonsillar area and palatine arch. , 1966, The American journal of roentgenology, radium therapy, and nuclear medicine.

[25]  E. Strong,et al.  Value of preoperative x-ray therapy as an adjunct to radical neck dissection. , 1966, Radiology.

[26]  G. Fletcher,et al.  Evaluation of Elective Irradiation of the Neck for Squamous-Cell Carcinoma of the Nasopharynx, Tonsillar Fossa, and Base of Tongue , 1963 .

[27]  W. Rider.  Epithelial cancer of the tonsillar area. , 1962, Radiology.