Stable expression of the human thrombomodulin transgene in pig endothelial cells is associated with a reduction in the inflammatory response.

[1]  D. Cooper,et al.  Is interleukin‐6 receptor blockade (tocilizumab) beneficial or detrimental to pig‐to‐baboon organ xenotransplantation? , 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[2]  Z. Cai,et al.  TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression , 2019, Cell Communication and Signaling.

[3]  C. Esmon,et al.  Evidence for the important role of inflammation in xenotransplantation , 2019, Journal of Inflammation.

[4]  E. Wolf,et al.  Consistent success in life-supporting porcine cardiac xenotransplantation , 2018, Nature.

[5]  Z. Cai,et al.  Porcine IL‐6, IL‐1β, and TNF‐α regulate the expression of pro‐inflammatory‐related genes and tissue factor in human umbilical vein endothelial cells , 2018, Xenotransplantation.

[6]  Z. Cai,et al.  Human IL‐6, IL‐17, IL‐1β, and TNF‐α differently regulate the expression of pro‐inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells , 2017, Xenotransplantation.

[7]  M. Wijkstrom,et al.  Therapeutic regulation of systemic inflammation in xenograft recipients , 2017, Xenotransplantation.

[8]  E. Klein,et al.  Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts , 2017, Xenotransplantation.

[9]  Michelle L. Miller,et al.  Erosion of Transplantation Tolerance After Infection , 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[10]  E. Wolf,et al.  Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation , 2016, Transplantation.

[11]  S. Chadban,et al.  Role of TLRs and DAMPs in allograft inflammation and transplant outcomes , 2016, Nature Reviews Nephrology.

[12]  R. F. Hoyt,et al.  Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft , 2016, Nature Communications.

[13]  R. Bottino,et al.  The pathobiology of pig‐to‐primate xenotransplantation: a historical review , 2016, Xenotransplantation.

[14]  M. Wijkstrom,et al.  Further evidence for sustained systemic inflammation in xenograft recipients (SIXR) , 2015, Xenotransplantation.

[15]  C. Ahn,et al.  Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno‐immune response , 2015, Xenotransplantation.

[16]  E. Wolf,et al.  Pig‐to‐baboon heterotopic heart transplantation – exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade‐based regimens , 2015, Xenotransplantation.

[17]  K. Iwasaki,et al.  Functional Difference Between Membrane-bound and Soluble Human Thrombomodulin , 2015, Transplantation.

[18]  T. Ikezoe.  Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation , 2015, Journal of Intensive Care.

[19]  R. Pierson,et al.  Systemic inflammation in xenograft recipients precedes activation of coagulation , 2015, Xenotransplantation.

[20]  J. Stypmann,et al.  Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling. , 2014, Cardiovascular research.

[21]  E. Wolf,et al.  Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs , 2014, Transplantation.

[22]  D. Cooper,et al.  Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition , 2014, Xenotransplantation.

[23]  T. Madhusudhan,et al.  The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition , 2012, Thrombosis and Haemostasis.

[24]  Hua-Lin Wu,et al.  The role of thrombomodulin lectin-like domain in inflammation , 2012, Journal of Biomedical Science.

[25]  K. Iwasaki,et al.  Production of cloned pigs expressing human thrombomodulin in endothelial cells , 2012, Xenotransplantation.

[26]  M. Shimaoka,et al.  Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis , 2012, Critical care research and practice.

[27]  E. Conway.  Thrombomodulin and its role in inflammation , 2011, Seminars in Immunopathology.

[28]  L. Turka,et al.  Innate immunity in transplant tolerance and rejection , 2011, Immunological reviews.

[29]  H. Iwasaka,et al.  IN VIVO AND IN VITRO EFFECTS OF THE ANTICOAGULANT, THROMBOMODULIN, ON THE INFLAMMATORY RESPONSE IN RODENT MODELS , 2010, Shock.

[30]  E. Salvaris,et al.  Antiinflammatory and Anticoagulant Effects of Transgenic Expression of Human Thrombomodulin in Mice , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[31]  H. Niemann,et al.  Pigs transgenic for human thrombomodulin have elevated production of activated protein C , 2009, Xenotransplantation.

[32]  D. Goldstein,et al.  IL-6 and TNF-alpha synergistically inhibit allograft acceptance. , 2009, Journal of the American Society of Nephrology : JASN.

[33]  S. Yamada,et al.  Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[34]  H. Nandurkar,et al.  Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[35]  A. D'apice,et al.  The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them , 2008, Current opinion in organ transplantation.

[36]  P. Cowan.  Coagulation and the xenograft endothelium , 2007, Xenotransplantation.

[37]  M. Daha,et al.  The lectin‐like domain of thrombomodulin interferes with complement activation and protects against arthritis , 2006, Journal of thrombosis and haemostasis : JTH.

[38]  A. Lumsden,et al.  C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. , 2005, Surgery.

[39]  R. H. Sohn,et al.  Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B. , 2005, Blood.

[40]  Hiroshi Yamamoto,et al.  The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. , 2005, The Journal of clinical investigation.

[41]  Cheng-Ruei Liu,et al.  Evidence of Human Thrombomodulin Domain as a Novel Angiogenic Factor , 2005, Circulation.

[42]  P. Hellings,et al.  The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways , 2002, The Journal of experimental medicine.

[43]  C. Esmon.  The protein C pathway. , 2003, Critical care medicine.

[44]  B. Woda,et al.  Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody , 2000, Journal of Virology.

[45]  C. Esmon.  Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  R. Jackman,et al.  Heat shock of vascular endothelial cells induces an up-regulatory transcriptional response of the thrombomodulin gene that is delayed in onset and does not attenuate. , 1994, The Journal of biological chemistry.

[47]  S. Hirosawa,et al.  Functional characterization of the 5'-regulatory region of the human thrombomodulin gene. , 1993, Journal of biochemistry.

[48]  J. Sadler,et al.  Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms. , 1991, Blood.

[49]  K. Hirokawa,et al.  Up-regulation of thrombomodulin in human umbilical vein endothelial cells in vitro. , 1990, Journal of biochemistry.

[50]  C. Esmon,et al.  Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. , 1989, Blood.

[51]  R. Rosenberg,et al.  Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells , 1988, Molecular and cellular biology.

[52]  S. Yamamoto,et al.  Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. , 1987, The EMBO journal.