Firefly luciferase: the structure is known, but the mystery remains.

The structure of firefly luciferase reveals a new protein fold which may be representative of a growing family of homologous enzymes.

[1]  I. Connerton,et al.  Comparison and cross‐species expression of the acetyl‐CoA synthetase genes of the ascomycete fungi, Aspergillus nidulans and Neurospora crassa , 1990, Molecular microbiology.

[2]  N Kajiyama,et al.  Isolation and characterization of mutants of firefly luciferase which produce different colors of light. , 1991, Protein engineering.

[3]  The spectral distribution of firefly light. II , 1964 .

[4]  F. Hartl,et al.  The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. H. Crosa,et al.  A regulatory gene, angR, of the iron uptake system of Vibrio anguillarum: similarity with phage P22 cro and regulation by iron. , 1990, Gene.

[6]  W. D. Mcelroy,et al.  Kinetics of the firefly luciferase catalyzed reactions. , 1974, Biochemistry.

[7]  E. Rapaport,et al.  Chemi- and bioluminescence of firefly luciferin. , 1969, Journal of the American Chemical Society.

[8]  Emil H. White,et al.  THE STRUCTURE AND SYNTHESIS OF FIREFLY LUCIFERIN , 1961 .

[9]  K. Hahlbrock,et al.  4-Coumarate:CoA ligase from cell suspension cultures of Petroselinum hortense Hoffm. Partial purification, substrate specificity, and further properties. , 1977, Archives of Biochemistry and Biophysics.

[10]  J. Kondo,et al.  Structure and regulation of rat long-chain acyl-CoA synthetase. , 1990, The Journal of biological chemistry.

[11]  A. Fisher,et al.  Three-dimensional structure of bacterial luciferase from Vibrio harveyi at 2.4 A resolution. , 1995, Biochemistry.

[12]  Emil H. White,et al.  The chemi- and bioluminescence of firefly luciferin: An efficient chemical production of electronically excited states , 1971 .

[13]  H. von Döhren,et al.  Nonribosomal biosynthesis of peptide antibiotics. , 1990, European journal of biochemistry.

[14]  J. Martín,et al.  Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains , 1991, Journal of bacteriology.

[15]  W. D. Mcelroy,et al.  Quantum yield in the oxidation of firefly luciferin , 1959 .

[16]  C. Walsh,et al.  Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. , 1991, Biochemistry.

[17]  M. Becker‐André,et al.  Structural comparison, modes of expression, and putative cis-acting elements of the two 4-coumarate: CoA ligase genes in potato. , 1991, The Journal of biological chemistry.

[18]  W. D. Mcelroy,et al.  THE COLORS OF FIREFLY BIOLUMINESCENCE: ENZYME CONFIGURATION AND SPECIES SPECIFICITY. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[19]  P. Babbitt,et al.  Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases. , 1992, Biochemistry.

[20]  T. Baldwin,et al.  Luciferase from the east European firefly Luciola mingrelica: cloning and nucleotide sequence of the cDNA, overexpression in Escherichia coli and purification of the enzyme. , 1993, Biochimica et biophysica acta.

[21]  J F Sinclair,et al.  Structure of bacterial luciferase. , 1995, Current opinion in structural biology.

[22]  T. Goto,et al.  Studies on firefly bioluminescence—II: Identification of oxyluciferin as a product in the bioluminescence of firefly lanterns and in the chemiluminescence of firefly luciferin , 1972 .

[23]  A. Fedorov,et al.  Contribution of cotranslational folding to the rate of formation of native protein structure. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Wood THE CHEMICAL MECHANISM and EVOLUTIONARY DEVELOPMENT OF BEETLE BIOLUMINESCENCE , 1995 .

[25]  O. Shimomura,et al.  Source of oxygen in the CO(2) produced in the bioluminescent oxidation of firefly luciferin. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[26]  N N Ugarova,et al.  Luciferase of Luciola mingrelica fireflies. Kinetics and regulation mechanism. , 1989, Journal of bioluminescence and chemiluminescence.

[27]  A. Maccabe,et al.  Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway. , 1991, The Journal of biological chemistry.

[28]  P. Herring Bioluminescence in action , 1978 .

[29]  W. D. Mcelroy,et al.  Spectral emission and quantum yield of firefly bioluminescence. , 1960, Archives of biochemistry and biophysics.

[30]  M. Marahiel,et al.  Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases , 1989, Journal of bacteriology.

[31]  M. Deluca,et al.  The sulfhydryls of firefly luciferase are not essential for activity. , 1986, Biochemistry.

[32]  P. Babbitt,et al.  Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic. , 1991, Science.

[33]  C. Walsh,et al.  Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product. , 1989, Biochemistry.

[34]  W. D. Mcelroy,et al.  Introduction to beetle luciferases and their applications. , 1989, Journal of bioluminescence and chemiluminescence.

[35]  W D McElroy,et al.  Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. , 1989, Science.

[36]  F. Mȕller Chemistry and Biochemistry of Flavoenzymes: Volume I , 1991 .

[37]  T. Holzman,et al.  Proteolytic inactivation of luciferases from three species of luminous marine bacteria, Beneckea harveyi, Photobacterium fischeri, and Photobacterium phosphoreum: evidence of a conserved structural feature. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[38]  W. D. Mcelroy,et al.  Crystalline firefly luciferase. , 1956, Biochimica et biophysica acta.

[39]  M. Ziegler,et al.  Bacterial luciferase: demonstration of a catalytically competent altered conformational state following a single turnover. , 1985, Biochemistry.

[40]  T. Baldwin,et al.  Use of bacterial and firefly luciferases as reporter genes in DEAE-dextran-mediated transfection of mammalian cells. , 1992, Analytical biochemistry.

[41]  J. Lancaster Bioluminescence and chemiluminescence. Current status: Edited by Philip E. Stanley and Larry J. Kricka. Pp. 570. Wiley, Chichester. 1991. £80.00 , 1991 .

[42]  R. Roskoski,et al.  Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185). , 1970, Biochemistry.

[43]  P. Brick,et al.  Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. , 1996, Structure.