论文信息 - cells and macrophages. infection and expression of defective virus in T defective virus and are required for efficient In murine AIDS, B cells are early targets of

cells and macrophages. infection and expression of defective virus in T defective virus and are required for efficient In murine AIDS, B cells are early targets of

spleens ofmutantmiceuntil 6weekspostinfection. Onprolongedexposuresofthesameblot,signals ofBM5def-related sequenceswerefoundat extremelylowlevels at the earlier time points (data not shown).Althoughunlikely, it wasformallypossible thatmutantmicemight carry strain 129 genes linked to the mutant Ig heavy-chain locus that could inhibit spread andexpression ofdefec-tive virus and induction of disease when present in thehomozygous state in B6*

D. Longo | H. Morse | Wankee Kim | Y. Tang | J. Kenny

[1] M. Emerman,et al. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus , 1994, Journal of virology.

[2] P. Jolicoeur. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3] Andreas Radbruch,et al. High gradient magnetic cell separation with MACS. , 1990, Cytometry.

[4] H. Morse,et al. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. , 1989, Proceedings of the National Academy of Sciences of the United States of America.