A Flexible, Open, Decentralized System for Digital Pathology Networks

High-resolution digital imaging is enabling digital archiving and sharing of digitized microscopy slides and new methods for digital pathology. Collaborative research centers, outsourced medical services, and multi-site organizations stand to benefit from sharing pathology data in a digital pathology network. Yet significant technological challenges remain due to the large size and volume of digitized whole slide images. While information systems do exist for managing local pathology laboratories, they tend to be oriented toward narrow clinical use cases or offer closed ecosystems around proprietary formats. Few solutions exist for networking digital pathology operations. Here we present a system architecture and implementation of a digital pathology network and share results from a production system that federates major research centers.

[1]  Michael Gruenberger,et al.  Pathbase: a database of mutant mouse pathology , 2004, Nucleic Acids Res..

[2]  Steven J Potts,et al.  Digital pathology in drug discovery and development: multisite integration. , 2009, Drug discovery today.

[3]  Lily I. Cheng.  Ode to Pathology Images Online! , 2007 .

[4]  Norman W. Paton,et al.  The design and implementation of Grid database services in OGSA‐DAI , 2005, Concurr. Pract. Exp..

[5]  Norman W. Paton,et al.  OGSA-DQP: A Service for Distributed Querying on the Grid , 2004, EDBT.

[6]  M Judy.  WebPath: The Internet Pathology Laboratory for Medical Education on CD-ROM , 2000 .

[7]  Shawn Mikula,et al.  Internet-enabled high-resolution brain mapping and virtual microscopy , 2007, NeuroImage.

[8]  Ian T. Foster,et al.  Security for Grid services , 2003, High Performance Distributed Computing, 2003. Proceedings. 12th IEEE International Symposium on.

[9]  Harvey J Karten,et al.  High‐resolution digital brain atlases: a Hubble telescope for the brain , 2011, Annals of the New York Academy of Sciences.

[10]  Timothy R. Olsen,et al.  The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data. , 2007, Neuroinformatics.

[11]  K. Eliceiri,et al.  Bioimage informatics for experimental biology. , 2009, Annual review of biophysics.

[12]  S. Joshi,et al.  High-throughput zebrafish histology. , 2006, Methods.

[13]  David B Keator,et al.  Management of information in distributed biomedical collaboratories. , 2009, Methods in molecular biology.

[14]  Roy T. Fielding,et al.  Principled design of the modern Web architecture , 2000, Proceedings of the 2000 International Conference on Software Engineering. ICSE 2000 the New Millennium.

[15]  Jessica A. Turner,et al.  Neuroscience Data Integration through Mediation: An (F)BIRN Case Study , 2010, Front. Neuroinform..

[16]  Ilya G. Goldberg,et al.  Open microscopy environment , 2005, 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05).

[17]  Bruce R. Rosen,et al.  Enabling collaborative research using the Biomedical Informatics Research Network (BIRN) , 2011, J. Am. Medical Informatics Assoc..

[18]  Kristopher N Jones,et al.  Group for research in pathology education online resources to facilitate pathology instruction. , 2002, Archives of pathology & laboratory medicine.

[19]  David B. Keator,et al.  A National Human Neuroimaging Collaboratory Enabled by the Biomedical Informatics Research Network (BIRN) , 2008, IEEE Transactions on Information Technology in Biomedicine.