Alzheimer's disease and post-operative cognitive dysfunction

[1]  M. Mattson,et al.  Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. , 2008, Journal of neurochemistry.

[2]  R. Tanzi,et al.  The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid &bgr; Protein Levels , 2006, Anesthesiology.

[3]  R. Tanzi Tangles and neurodegenerative disease--a surprising twist. , 2005, The New England journal of medicine.

[4]  L. Glavaš-Obrovac,et al.  Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines. , 2005, Life sciences.

[5]  P. Greengard,et al.  Regulation of NMDA receptor trafficking by amyloid-β , 2005, Nature Neuroscience.

[6]  R. Tanzi The synaptic Aβ hypothesis of Alzheimer disease , 2005, Nature Neuroscience.

[7]  B. Hyman,et al.  Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.

[8]  C. Borner,et al.  Volatile Anesthetics Induce Caspase-dependent, Mitochondria-mediated Apoptosis in Human T Lymphocytes In Vitro , 2005, Anesthesiology.

[9]  R. Tanzi,et al.  RNA Interference-mediated Silencing of X11α and X11β Attenuates Amyloid β-Protein Levels via Differential Effects on β-Amyloid Precursor Protein Processing* , 2005, Journal of Biological Chemistry.

[10]  Q. C. Meng,et al.  Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently , 2005, Brain Research.

[11]  D. Blacker,et al.  Family-based association between Alzheimer's disease and variants in UBQLN1. , 2005, The New England journal of medicine.

[12]  P. Bickler,et al.  Isoflurane Neuroprotection in Hypoxic Hippocampal Slice Cultures Involves Increases in Intracellular Ca2+ and Mitogen-activated Protein Kinases , 2005, Anesthesiology.

[13]  R. Tanzi,et al.  Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective , 2005, Cell.

[14]  Yunzhou Dong,et al.  Identification of a New Presenilin-dependent ζ-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein*♦ , 2004, Journal of Biological Chemistry.

[15]  R. Pearlstein,et al.  Apoptosis Is Not Enhanced in Primary Mixed Neuronal/Glial Cultures Protected by Isoflurane Against N-Methyl-d-Aspartate Excitotoxicity , 2004, Anesthesia and analgesia.

[16]  R. Tanzi,et al.  Clearance of Alzheimer's Aβ PeptideThe Many Roads to Perdition , 2004 .

[17]  M. Eckenhoff,et al.  Inhaled Anesthetic Enhancement of Amyloid-&bgr; Oligomerization and Cytotoxicity , 2004, Anesthesiology.

[18]  R. Tanzi,et al.  Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition , 2004, Neuron.

[19]  R. Tanzi,et al.  Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation* , 2004, Journal of Biological Chemistry.

[20]  T. Beach,et al.  Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease , 2004, Neurological research.

[21]  R. Tanzi,et al.  Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production , 2004, Neurodegenerative Diseases.

[22]  D. Selkoe,et al.  Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. , 2004, The American journal of pathology.

[23]  M. Kawaguchi,et al.  Effect of Isoflurane on Neuronal Apoptosis in Rats Subjected to Focal Cerebral Ischemia , 2004, Anesthesia and analgesia.

[24]  J. Schneider,et al.  Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. , 2004, Archives of neurology.

[25]  A. Schneider,et al.  Endoplasmic Reticulum‐Localized Amyloid β‐Peptide is Degraded in the Cytosol by Two Distinct Degradation Pathways , 2004, Traffic.

[26]  M. Baxter,et al.  Long-term Impairment of Acquisition of a Spatial Memory Task following Isoflurane–Nitrous Oxide Anesthesia in Rats , 2004, Anesthesiology.

[27]  S. Blaise,et al.  Neonatal Hypoxia Triggers Transient Apoptosis Followed by Neurogenesis in the Rat CA1 Hippocampus , 2004, Pediatric Research.

[28]  D. Selkoe,et al.  Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. , 2004, Biochemistry.

[29]  D. Selkoe,et al.  Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death , 2003, Neuron.

[30]  L. Hersh,et al.  Substrate Activation of Insulin-degrading Enzyme (Insulysin) , 2003, Journal of Biological Chemistry.

[31]  B. de Strooper,et al.  Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin* , 2003, Journal of Biological Chemistry.

[32]  R. Doms,et al.  The Transmembrane Domain Region of Nicastrin Mediates Direct Interactions with APH-1 and the γ-Secretase Complex* , 2003, Journal of Biological Chemistry.

[33]  D. Selkoe,et al.  Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin* , 2003, Journal of Biological Chemistry.

[34]  Chunjiang Yu,et al.  Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. , 2003, The Journal of biological chemistry.

[35]  P. Vito,et al.  Autosomal Recessive Hypercholesterolemia Protein Interacts with and Regulates the Cell Surface Level of Alzheimer's Amyloid β Precursor Protein* , 2003, Journal of Biological Chemistry.

[36]  K. Miyazawa,et al.  A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1* , 2003, Journal of Biological Chemistry.

[37]  K. Miller,et al.  Mechanisms of actions of inhaled anesthetics. , 2003, The New England journal of medicine.

[38]  J. Schmitz,et al.  γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin* , 2003, The Journal of Biological Chemistry.

[39]  Michael S. Wolfe,et al.  γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  L. Hersh,et al.  Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Mesulam,et al.  Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. , 2003, Archives of neurology.

[42]  J. Regula,et al.  Reconstitution of γ-secretase activity , 2003, Nature Cell Biology.

[43]  B. Strooper,et al.  Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex , 2003, Neuron.

[44]  Harold L. Ickes,et al.  Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[45]  T. Iwatsubo,et al.  The role of presenilin cofactors in the γ-secretase complex , 2003, Nature.

[46]  F. Gage,et al.  Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice , 2003, The Journal of Neuroscience.

[47]  Matthew P. Frosch,et al.  Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[48]  P. S. St George-Hyslop,et al.  APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes* , 2003, The Journal of Biological Chemistry.

[49]  S. DeKosky,et al.  Association of the 3′ UTR transcription factor LBP‐1c/CP2/LSF polymorphism with late‐onset Alzheimer's disease , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[50]  Doo Yeon Kim,et al.  Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage* , 2002, The Journal of Biological Chemistry.

[51]  B. Wolozin,et al.  Hypoxia Enhances β-Amyloid-Induced Apoptosis in Rat cultured Hippocampal Neurons , 2002 .

[52]  C. Peers,et al.  Altered processing of amyloid precursor protein in the human neuroblastoma SH‐SY5Y by chronic hypoxia , 2002, Journal of neurochemistry.

[53]  Hongqiao Li,et al.  Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch* , 2002, The Journal of Biological Chemistry.

[54]  Harald Steiner,et al.  Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide* , 2002, The Journal of Biological Chemistry.

[55]  K. Jellinger,et al.  The pathology of ischemic-vascular dementia An update , 2002, Journal of the Neurological Sciences.

[56]  T. Russo,et al.  Signal Transduction through Tyrosine‐Phosphorylated Carboxy‐Terminal Fragments of APP via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain , 2002, Annals of the New York Academy of Sciences.

[57]  Harald Steiner,et al.  PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin* , 2002, The Journal of Biological Chemistry.

[58]  W. Klapper,et al.  Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12 , 2002, Neurobiology of Disease.

[59]  T. Russo,et al.  Signal Transduction through Tyrosine-phosphorylated C-terminal Fragments of Amyloid Precursor Protein via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain* , 2002, The Journal of Biological Chemistry.

[60]  T. Südhof,et al.  Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms , 2002, The Journal of Neuroscience.

[61]  R. Turner,et al.  Synergistic Effects of Munc18a and X11 Proteins on Amyloid Precursor Protein Metabolism* , 2002, The Journal of Biological Chemistry.

[62]  Wei Xu,et al.  aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation , 2002 .

[63]  L. Palmer,et al.  Isoflurane Pretreatment Inhibits Cytokine-induced Cell Death in Cultured Rat Smooth Muscle Cells and Human Endothelial Cells , 2002, Anesthesiology.

[64]  C. Peers,et al.  Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid β peptide formation and reactive oxygen species generation , 2002, The Journal of physiology.

[65]  J. Herz,et al.  Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain* , 2002, The Journal of Biological Chemistry.

[66]  P. Rakic,et al.  The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[67]  P. Pelicci,et al.  Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc* , 2002, The Journal of Biological Chemistry.

[68]  G. Serban,et al.  A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions , 2002, The EMBO journal.

[69]  W. K. Cullen,et al.  Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.

[70]  Sangram S. Sisodia,et al.  γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in? , 2002, Nature Reviews Neuroscience.

[71]  D. Selkoe,et al.  Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[72]  R. Roncarati,et al.  Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)* , 2002, The Journal of Biological Chemistry.

[73]  C. Masters,et al.  A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. , 2002, Biochemistry.

[74]  Valerie A. Hale,et al.  APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[75]  T. Horinouchi,et al.  Inhalation Anesthetics Induce Apoptosis in Normal Peripheral Lymphocytes In Vitro , 2001, Anesthesiology.

[76]  S. H. Kim,et al.  Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ , 2001, The Journal of Biological Chemistry.

[77]  M. Raizada,et al.  Oxygen and Glucose Deprivation-Induced Neuronal Apoptosis is Attenuated by Halothane and Isoflurane , 2001, Anesthesia and analgesia.

[78]  T. Golde,et al.  γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase , 2001, Science.

[79]  Lars Bertram,et al.  New Frontiers in Alzheimer's Disease Genetics , 2001, Neuron.

[80]  Y. Ihara,et al.  Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch* , 2001, The Journal of Biological Chemistry.

[81]  Klaus Fuchs,et al.  Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch , 2001 .

[82]  T. Hiraki,et al.  c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK , 2001, The Journal of Neuroscience.

[83]  R. Nitsch,et al.  Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.

[84]  J. Hardy,et al.  Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.

[85]  Thomas C. Südhof,et al.  A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 , 2001, Science.

[86]  Jonathan C. Cohen,et al.  Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein , 2001, Science.

[87]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[88]  Frances J. Northington,et al.  Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis , 2001, Neurobiology of Disease.

[89]  Mark F. Newman,et al.  Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. , 2001, The New England journal of medicine.

[90]  M G McInnis,et al.  Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. , 2000, Science.

[91]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[92]  J. Poirier,et al.  Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism , 2000, Annals of the New York Academy of Sciences.

[93]  Ruedi Aebersold,et al.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.

[94]  S. Takashima,et al.  Hypocapnia Under Hypotension Induces Apoptotic Neuronal Cell Death in the Hippocampus of Newborn Rabbits , 2000, Pediatric Research.

[95]  E. Lucchinetti,et al.  Norepinephrine-induced Apoptosis Is Inhibited in Adult Rat Ventricular Myocytes Exposed to Volatile Anesthetics , 2000, Anesthesiology.

[96]  C. Soto,et al.  Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis , 2000, Nature Network Boston.

[97]  Min Xu,et al.  Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[98]  R. Kalaria The role of cerebral ischemia in Alzheimer’s disease , 2000, Neurobiology of Aging.

[99]  M. Breteler,et al.  Vascular risk factors for Alzheimer’s disease: An epidemiologic perspective , 2000, Neurobiology of Aging.

[100]  M. Mattson,et al.  Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal Ischemia In Vivo and to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis , 2000, The Journal of Neuroscience.

[101]  P. George-Hyslop Molecular genetics of Alzheimer’s disease , 2000, Biological Psychiatry.

[102]  Alfredo G. Tomasselli,et al.  Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity , 1999, Nature.

[103]  R. Tanzi,et al.  Staurosporine‐Induced Activation of Caspase‐3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells , 1999, Journal of neurochemistry.

[104]  David G. Tew,et al.  Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase , 1999, Molecular and Cellular Neuroscience.

[105]  G. Thinakaran The role of presenilins in Alzheimer's disease. , 1999, The Journal of clinical investigation.

[106]  R. Tanzi,et al.  A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. , 1999, The Journal of clinical investigation.

[107]  B. Strooper,et al.  The presenilins in Alzheimer's disease--proteolysis holds the key. , 1999, Science.

[108]  J. Treanor,et al.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.

[109]  Joachim Herz,et al.  Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation , 1999, Neuron.

[110]  I. Lieberburg,et al.  Cellular mechanisms of beta-amyloid production and secretion. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[111]  Zsuzsanna Nagy,et al.  Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease , 1999, The Lancet.

[112]  Gary Lynch,et al.  Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice , 1999, Brain Research.

[113]  Ramin Homayouni,et al.  Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1 , 1999, The Journal of Neuroscience.

[114]  R. Tanzi,et al.  hFE65L Influences Amyloid Precursor Protein Maturation and Secretion , 1999, Journal of neurochemistry.

[115]  David Smith,et al.  Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation , 1999, Cell.

[116]  D. Selkoe,et al.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.

[117]  William J. Ray,et al.  A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.

[118]  P. Greengard,et al.  Regulation of β-Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein* , 1999, The Journal of Biological Chemistry.

[119]  S. Shimohama,et al.  Changes in caspase expression in Alzheimer's disease: comparison with development and aging. , 1999, Biochemical and biophysical research communications.

[120]  E. Wijsman,et al.  Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. , 1999, American journal of human genetics.

[121]  T. Tabira,et al.  Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's β-amyloid precursor protein , 1999, Neuroscience Letters.

[122]  J. Borg,et al.  Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein* , 1998, The Journal of Biological Chemistry.

[123]  S. Pimplikar,et al.  PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[124]  L. Hersh,et al.  Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* , 1998, The Journal of Biological Chemistry.

[125]  J. Mandel,et al.  Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases , 1998 .

[126]  W. Shen,et al.  Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures , 1998, The Journal of Neuroscience.

[127]  J. Lindstrom,et al.  Ion channel modulation as the basis for general anesthesia. , 1998, Toxicology letters.

[128]  W. R. Lieb,et al.  Which molecular targets are most relevant to general anaesthesia? , 1998, Toxicology letters.

[129]  E. Masliah,et al.  Caspase Dependent DNA Fragmentation Might Be Associated with Excitotoxicity in Alzheimer Disease , 1998, Journal of neuropathology and experimental neurology.

[130]  Hans Clevers,et al.  Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis , 1998, Nature.

[131]  J. Allison,et al.  Postoperative cognitive deficit in the elderly surgical patient. , 1998, British journal of anaesthesia.

[132]  R. Oppenheim,et al.  Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons , 1998, The Journal of Neuroscience.

[133]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[134]  M. Moskowitz,et al.  Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.

[135]  P. Rabbitt,et al.  Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study , 1998, The Lancet.

[136]  J. Palacino,et al.  Regulation of Apoptosis by Presenilin 1 , 1998, Neurobiology of Aging.

[137]  T. Russo,et al.  Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. , 1998, The Biochemical journal.

[138]  H. Vinters,et al.  Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. , 1998, The American journal of pathology.

[139]  D. Borchelt,et al.  Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin* , 1997, The Journal of Biological Chemistry.

[140]  O. Hoffmann,et al.  Amyloid β Peptide and Precursor Protein (APP) in Mild and Severe Brain Ischemia , 1997 .

[141]  D. Holtzman,et al.  Caspases: A treatment target for neurodegenerative disease? , 1997, Nature Medicine.

[142]  H. Loetscher,et al.  Presenilins Are Processed by Caspase-type Proteases* , 1997, The Journal of Biological Chemistry.

[143]  R. Tanzi,et al.  Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. , 1997, Science.

[144]  D. Price,et al.  Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm , 1997, Nature.

[145]  John Hardy,et al.  Amyloid, the presenilins and Alzheimer's disease , 1997, Trends in Neurosciences.

[146]  W. Markesbery,et al.  Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. , 1997, JAMA.

[147]  J. Buxbaum,et al.  Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins* , 1997, The Journal of Biological Chemistry.

[148]  P. S. St George-Hyslop,et al.  Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins* , 1997, The Journal of Biological Chemistry.

[149]  A. Smith,et al.  The Effects of Additional Pathology on the Cognitive Deficit in Alzheimer Disease , 1997, Journal of neuropathology and experimental neurology.

[150]  Richard Hollister,et al.  Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease , 1997, Annals of neurology.

[151]  C. Cotman,et al.  Bax Protein Expression Is Increased in Alzheimer's Brain: Correlations with DNA Damage, Bcl‐2 Expression, and Brain Pathology , 1997, Journal of neuropathology and experimental neurology.

[152]  M. Mattson,et al.  Alzheimer's PS‐1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β‐peptide , 1996, Neuroreport.

[153]  C. Miller,et al.  The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. , 1996, FEBS letters.

[154]  T. Hökfelt,et al.  Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. , 1996, Neuroreport.

[155]  I. Greenwald,et al.  Membrane Topology of the C. elegans SEL-12 Presenilin , 1996, Neuron.

[156]  B. Margolis,et al.  The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein , 1996, Molecular and cellular biology.

[157]  E. Tani,et al.  Cytotoxic Fragment of Amyloid Precursor Protein Accumulates in Hippocampus after Global Forebrain Ischemia , 1996, Journal of Cerebral Blood Flow and Metabolism.

[158]  D. Borchelt,et al.  Protein Topology of Presenilin 1 , 1996, Neuron.

[159]  Y. Stern,et al.  Risk factors for incident dementia after stroke. Role of hypoxic and ischemic disorders. , 1996, Stroke.

[160]  G. Schellenberg,et al.  Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.

[161]  D. Borchelt,et al.  Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo , 1996, Neuron.

[162]  E. Matsubara,et al.  Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[163]  W. O'Fallon,et al.  Dementia after ischemic stroke , 1996, Neurology.

[164]  T. Russo,et al.  The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein (*) , 1995, The Journal of Biological Chemistry.

[165]  M. Adams,et al.  A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene , 1995, Neuroreport.

[166]  J. Rommens,et al.  Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.

[167]  G. Schellenberg,et al.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.

[168]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[169]  Brian J Cummings,et al.  Immunohistochemical evidence for apoptosis in Alzheimer's disease. , 1994, Neuroreport.

[170]  R. Mayeux,et al.  Risk of dementia after stroke in a hospitalized cohort , 1994, Neurology.

[171]  J. Kimura,et al.  Temporal Profiles of Accumulation of Amyloid β/A4 Protein Precursor in the Gerbil after Graded Ischemic Stress , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[172]  N. Bohnen,et al.  Alzheimer's Disease and Cumulative Exposure to Anesthesia: A Case‐Control Study , 1994, Journal of the American Geriatrics Society.

[173]  K. Kogure,et al.  Altered Gene Expression in Cerebral Ischemia , 1993, Stroke.

[174]  K. Jellinger,et al.  Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients , 1993, Neuroscience Letters.

[175]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[176]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[177]  J. Weber,et al.  Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.

[178]  Bradley T. Hyman,et al.  Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease , 1992, Neurology.

[179]  D. Salmon,et al.  Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.

[180]  R. Tanzi,et al.  Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex , 1991, Neuroscience Letters.

[181]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[182]  J. Trojanowski,et al.  A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.

[183]  T. Oltersdorf,et al.  Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.

[184]  D. Price,et al.  Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.

[185]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[186]  D. Selkoe,et al.  Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[187]  J. Walker,et al.  Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[188]  S. Latt,et al.  The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. , 1987, Science.

[189]  H. Wiśniewski,et al.  Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[190]  G. Greisen,et al.  Cerebral Blood Flow, PaCO2 Changes, and Visual Evoked Potentials in Mechanically Ventilated, Preterm Infants , 1987, Acta paediatrica Scandinavica.

[191]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[192]  M. Lerman,et al.  Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. , 1987, Science.

[193]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[194]  H. Wiśniewski,et al.  Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[195]  D. Selkoe,et al.  Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[196]  C. Masters,et al.  Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[197]  G. Glenner,et al.  Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. , 1984, Biochemical and biophysical research communications.

[198]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .

[199]  M. Kirschner,et al.  A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[200]  S. Wollman,et al.  POSTOPERATIVE HUMAN REACTION TIME AND HYPOCARBIA DURING ANAESTHESIA , 1968 .

[201]  R. Tanzi,et al.  Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 , 2007, Journal of Molecular Neuroscience.

[202]  D. Selkoe,et al.  Natural oligomers of the amyloid-β protein specifically disrupt cognitive function , 2005, Nature Neuroscience.

[203]  F. Panza,et al.  LBP-1c/CP2/LSF gene polymorphism and risk of sporadic Alzheimer's disease. , 2004, Journal of neurology, neurosurgery, and psychiatry.

[204]  S. M. de la Monte,et al.  Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. , 2003, Journal of Alzheimer's disease : JAD.

[205]  M. Albert,et al.  Results of a high-resolution genome screen of 437 Alzheimer's disease families. , 2003, Human molecular genetics.

[206]  M. Wolfe The secretases of Alzheimer's disease. , 2003, Current topics in developmental biology.

[207]  M. Mattson Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease. , 2002, International review of neurobiology.

[208]  J. Wang,et al.  The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosisin vitro , 2001, Irish journal of medical science.

[209]  D L Price,et al.  Alzheimer's disease: genetic studies and transgenic models. , 1998, Annual review of genetics.

[210]  D. Price,et al.  Mutant genes in familial Alzheimer's disease and transgenic models. , 1998, Annual review of neuroscience.

[211]  Jonathan A. Cooper,et al.  Mouse disabled (mDab1): a Src binding protein implicated in neuronal development , 1997, The EMBO journal.

[212]  Deborah S. Smith,et al.  Parkinsonian symptoms during emergence from general anesthesia. , 1995, Anesthesiology.

[213]  N. Bohnen,et al.  Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. , 1994, The International journal of neuroscience.

[214]  A. Alzheimer Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .