Alzheimer's disease and post-operative cognitive dysfunction
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[1] M. Mattson,et al. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. , 2008, Journal of neurochemistry.
[2] R. Tanzi,et al. The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid &bgr; Protein Levels , 2006, Anesthesiology.
[3] R. Tanzi. Tangles and neurodegenerative disease--a surprising twist. , 2005, The New England journal of medicine.
[4] L. Glavaš-Obrovac,et al. Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines. , 2005, Life sciences.
[5] P. Greengard,et al. Regulation of NMDA receptor trafficking by amyloid-β , 2005, Nature Neuroscience.
[6] R. Tanzi. The synaptic Aβ hypothesis of Alzheimer disease , 2005, Nature Neuroscience.
[7] B. Hyman,et al. Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.
[8] C. Borner,et al. Volatile Anesthetics Induce Caspase-dependent, Mitochondria-mediated Apoptosis in Human T Lymphocytes In Vitro , 2005, Anesthesiology.
[9] R. Tanzi,et al. RNA Interference-mediated Silencing of X11α and X11β Attenuates Amyloid β-Protein Levels via Differential Effects on β-Amyloid Precursor Protein Processing* , 2005, Journal of Biological Chemistry.
[10] Q. C. Meng,et al. Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently , 2005, Brain Research.
[11] D. Blacker,et al. Family-based association between Alzheimer's disease and variants in UBQLN1. , 2005, The New England journal of medicine.
[12] P. Bickler,et al. Isoflurane Neuroprotection in Hypoxic Hippocampal Slice Cultures Involves Increases in Intracellular Ca2+ and Mitogen-activated Protein Kinases , 2005, Anesthesiology.
[13] R. Tanzi,et al. Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective , 2005, Cell.
[14] Yunzhou Dong,et al. Identification of a New Presenilin-dependent ζ-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein*♦ , 2004, Journal of Biological Chemistry.
[15] R. Pearlstein,et al. Apoptosis Is Not Enhanced in Primary Mixed Neuronal/Glial Cultures Protected by Isoflurane Against N-Methyl-d-Aspartate Excitotoxicity , 2004, Anesthesia and analgesia.
[16] R. Tanzi,et al. Clearance of Alzheimer's Aβ PeptideThe Many Roads to Perdition , 2004 .
[17] M. Eckenhoff,et al. Inhaled Anesthetic Enhancement of Amyloid-&bgr; Oligomerization and Cytotoxicity , 2004, Anesthesiology.
[18] R. Tanzi,et al. Clearance of Alzheimer's Aβ Peptide The Many Roads to Perdition , 2004, Neuron.
[19] R. Tanzi,et al. Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation* , 2004, Journal of Biological Chemistry.
[20] T. Beach,et al. Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease , 2004, Neurological research.
[21] R. Tanzi,et al. Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production , 2004, Neurodegenerative Diseases.
[22] D. Selkoe,et al. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. , 2004, The American journal of pathology.
[23] M. Kawaguchi,et al. Effect of Isoflurane on Neuronal Apoptosis in Rats Subjected to Focal Cerebral Ischemia , 2004, Anesthesia and analgesia.
[24] J. Schneider,et al. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. , 2004, Archives of neurology.
[25] A. Schneider,et al. Endoplasmic Reticulum‐Localized Amyloid β‐Peptide is Degraded in the Cytosol by Two Distinct Degradation Pathways , 2004, Traffic.
[26] M. Baxter,et al. Long-term Impairment of Acquisition of a Spatial Memory Task following Isoflurane–Nitrous Oxide Anesthesia in Rats , 2004, Anesthesiology.
[27] S. Blaise,et al. Neonatal Hypoxia Triggers Transient Apoptosis Followed by Neurogenesis in the Rat CA1 Hippocampus , 2004, Pediatric Research.
[28] D. Selkoe,et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. , 2004, Biochemistry.
[29] D. Selkoe,et al. Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death , 2003, Neuron.
[30] L. Hersh,et al. Substrate Activation of Insulin-degrading Enzyme (Insulysin) , 2003, Journal of Biological Chemistry.
[31] B. de Strooper,et al. Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin* , 2003, Journal of Biological Chemistry.
[32] R. Doms,et al. The Transmembrane Domain Region of Nicastrin Mediates Direct Interactions with APH-1 and the γ-Secretase Complex* , 2003, Journal of Biological Chemistry.
[33] D. Selkoe,et al. Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin* , 2003, Journal of Biological Chemistry.
[34] Chunjiang Yu,et al. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. , 2003, The Journal of biological chemistry.
[35] P. Vito,et al. Autosomal Recessive Hypercholesterolemia Protein Interacts with and Regulates the Cell Surface Level of Alzheimer's Amyloid β Precursor Protein* , 2003, Journal of Biological Chemistry.
[36] K. Miyazawa,et al. A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1* , 2003, Journal of Biological Chemistry.
[37] K. Miller,et al. Mechanisms of actions of inhaled anesthetics. , 2003, The New England journal of medicine.
[38] J. Schmitz,et al. γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin* , 2003, The Journal of Biological Chemistry.
[39] Michael S. Wolfe,et al. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[40] L. Hersh,et al. Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[41] M. Mesulam,et al. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. , 2003, Archives of neurology.
[42] J. Regula,et al. Reconstitution of γ-secretase activity , 2003, Nature Cell Biology.
[43] B. Strooper,et al. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex , 2003, Neuron.
[44] Harold L. Ickes,et al. Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[45] T. Iwatsubo,et al. The role of presenilin cofactors in the γ-secretase complex , 2003, Nature.
[46] F. Gage,et al. Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice , 2003, The Journal of Neuroscience.
[47] Matthew P. Frosch,et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[48] P. S. St George-Hyslop,et al. APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes* , 2003, The Journal of Biological Chemistry.
[49] S. DeKosky,et al. Association of the 3′ UTR transcription factor LBP‐1c/CP2/LSF polymorphism with late‐onset Alzheimer's disease , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[50] Doo Yeon Kim,et al. Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage* , 2002, The Journal of Biological Chemistry.
[51] B. Wolozin,et al. Hypoxia Enhances β-Amyloid-Induced Apoptosis in Rat cultured Hippocampal Neurons , 2002 .
[52] C. Peers,et al. Altered processing of amyloid precursor protein in the human neuroblastoma SH‐SY5Y by chronic hypoxia , 2002, Journal of neurochemistry.
[53] Hongqiao Li,et al. Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch* , 2002, The Journal of Biological Chemistry.
[54] Harald Steiner,et al. Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide* , 2002, The Journal of Biological Chemistry.
[55] K. Jellinger,et al. The pathology of ischemic-vascular dementia An update , 2002, Journal of the Neurological Sciences.
[56] T. Russo,et al. Signal Transduction through Tyrosine‐Phosphorylated Carboxy‐Terminal Fragments of APP via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain , 2002, Annals of the New York Academy of Sciences.
[57] Harald Steiner,et al. PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin* , 2002, The Journal of Biological Chemistry.
[58] W. Klapper,et al. Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12 , 2002, Neurobiology of Disease.
[59] T. Russo,et al. Signal Transduction through Tyrosine-phosphorylated C-terminal Fragments of Amyloid Precursor Protein via an Enhanced Interaction with Shc/Grb2 Adaptor Proteins in Reactive Astrocytes of Alzheimer's Disease Brain* , 2002, The Journal of Biological Chemistry.
[60] T. Südhof,et al. Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms , 2002, The Journal of Neuroscience.
[61] R. Turner,et al. Synergistic Effects of Munc18a and X11 Proteins on Amyloid Precursor Protein Metabolism* , 2002, The Journal of Biological Chemistry.
[62] Wei Xu,et al. aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation , 2002 .
[63] L. Palmer,et al. Isoflurane Pretreatment Inhibits Cytokine-induced Cell Death in Cultured Rat Smooth Muscle Cells and Human Endothelial Cells , 2002, Anesthesiology.
[64] C. Peers,et al. Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid β peptide formation and reactive oxygen species generation , 2002, The Journal of physiology.
[65] J. Herz,et al. Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain* , 2002, The Journal of Biological Chemistry.
[66] P. Rakic,et al. The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[67] P. Pelicci,et al. Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc* , 2002, The Journal of Biological Chemistry.
[68] G. Serban,et al. A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions , 2002, The EMBO journal.
[69] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[70] Sangram S. Sisodia,et al. γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in? , 2002, Nature Reviews Neuroscience.
[71] D. Selkoe,et al. Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[72] R. Roncarati,et al. Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)* , 2002, The Journal of Biological Chemistry.
[73] C. Masters,et al. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. , 2002, Biochemistry.
[74] Valerie A. Hale,et al. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[75] T. Horinouchi,et al. Inhalation Anesthetics Induce Apoptosis in Normal Peripheral Lymphocytes In Vitro , 2001, Anesthesiology.
[76] S. H. Kim,et al. Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ , 2001, The Journal of Biological Chemistry.
[77] M. Raizada,et al. Oxygen and Glucose Deprivation-Induced Neuronal Apoptosis is Attenuated by Halothane and Isoflurane , 2001, Anesthesia and analgesia.
[78] T. Golde,et al. γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase , 2001, Science.
[79] Lars Bertram,et al. New Frontiers in Alzheimer's Disease Genetics , 2001, Neuron.
[80] Y. Ihara,et al. Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch* , 2001, The Journal of Biological Chemistry.
[81] Klaus Fuchs,et al. Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch , 2001 .
[82] T. Hiraki,et al. c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK , 2001, The Journal of Neuroscience.
[83] R. Nitsch,et al. Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.
[84] J. Hardy,et al. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.
[85] Thomas C. Südhof,et al. A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 , 2001, Science.
[86] Jonathan C. Cohen,et al. Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein , 2001, Science.
[87] D. Selkoe. Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.
[88] Frances J. Northington,et al. Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis , 2001, Neurobiology of Disease.
[89] Mark F. Newman,et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. , 2001, The New England journal of medicine.
[90] M G McInnis,et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. , 2000, Science.
[91] D. Holtzman,et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.
[92] J. Poirier,et al. Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism , 2000, Annals of the New York Academy of Sciences.
[93] Ruedi Aebersold,et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.
[94] S. Takashima,et al. Hypocapnia Under Hypotension Induces Apoptotic Neuronal Cell Death in the Hippocampus of Newborn Rabbits , 2000, Pediatric Research.
[95] E. Lucchinetti,et al. Norepinephrine-induced Apoptosis Is Inhibited in Adult Rat Ventricular Myocytes Exposed to Volatile Anesthetics , 2000, Anesthesiology.
[96] C. Soto,et al. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis , 2000, Nature Network Boston.
[97] Min Xu,et al. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[98] R. Kalaria. The role of cerebral ischemia in Alzheimer’s disease , 2000, Neurobiology of Aging.
[99] M. Breteler,et al. Vascular risk factors for Alzheimer’s disease: An epidemiologic perspective , 2000, Neurobiology of Aging.
[100] M. Mattson,et al. Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal Ischemia In Vivo and to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis , 2000, The Journal of Neuroscience.
[101] P. George-Hyslop. Molecular genetics of Alzheimer’s disease , 2000, Biological Psychiatry.
[102] Alfredo G. Tomasselli,et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity , 1999, Nature.
[103] R. Tanzi,et al. Staurosporine‐Induced Activation of Caspase‐3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells , 1999, Journal of neurochemistry.
[104] David G. Tew,et al. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase , 1999, Molecular and Cellular Neuroscience.
[105] G. Thinakaran. The role of presenilins in Alzheimer's disease. , 1999, The Journal of clinical investigation.
[106] R. Tanzi,et al. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. , 1999, The Journal of clinical investigation.
[107] B. Strooper,et al. The presenilins in Alzheimer's disease--proteolysis holds the key. , 1999, Science.
[108] J. Treanor,et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.
[109] Joachim Herz,et al. Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation , 1999, Neuron.
[110] I. Lieberburg,et al. Cellular mechanisms of beta-amyloid production and secretion. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[111] Zsuzsanna Nagy,et al. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease , 1999, The Lancet.
[112] Gary Lynch,et al. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice , 1999, Brain Research.
[113] Ramin Homayouni,et al. Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1 , 1999, The Journal of Neuroscience.
[114] R. Tanzi,et al. hFE65L Influences Amyloid Precursor Protein Maturation and Secretion , 1999, Journal of neurochemistry.
[115] David Smith,et al. Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation , 1999, Cell.
[116] D. Selkoe,et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.
[117] William J. Ray,et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.
[118] P. Greengard,et al. Regulation of β-Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein* , 1999, The Journal of Biological Chemistry.
[119] S. Shimohama,et al. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. , 1999, Biochemical and biophysical research communications.
[120] E. Wijsman,et al. Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. , 1999, American journal of human genetics.
[121] T. Tabira,et al. Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's β-amyloid precursor protein , 1999, Neuroscience Letters.
[122] J. Borg,et al. Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein* , 1998, The Journal of Biological Chemistry.
[123] S. Pimplikar,et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[124] L. Hersh,et al. Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* , 1998, The Journal of Biological Chemistry.
[125] J. Mandel,et al. Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases , 1998 .
[126] W. Shen,et al. Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures , 1998, The Journal of Neuroscience.
[127] J. Lindstrom,et al. Ion channel modulation as the basis for general anesthesia. , 1998, Toxicology letters.
[128] W. R. Lieb,et al. Which molecular targets are most relevant to general anaesthesia? , 1998, Toxicology letters.
[129] E. Masliah,et al. Caspase Dependent DNA Fragmentation Might Be Associated with Excitotoxicity in Alzheimer Disease , 1998, Journal of neuropathology and experimental neurology.
[130] Hans Clevers,et al. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis , 1998, Nature.
[131] J. Allison,et al. Postoperative cognitive deficit in the elderly surgical patient. , 1998, British journal of anaesthesia.
[132] R. Oppenheim,et al. Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons , 1998, The Journal of Neuroscience.
[133] T. Morgan,et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[134] M. Moskowitz,et al. Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.
[135] P. Rabbitt,et al. Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study , 1998, The Lancet.
[136] J. Palacino,et al. Regulation of Apoptosis by Presenilin 1 , 1998, Neurobiology of Aging.
[137] T. Russo,et al. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. , 1998, The Biochemical journal.
[138] H. Vinters,et al. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. , 1998, The American journal of pathology.
[139] D. Borchelt,et al. Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin* , 1997, The Journal of Biological Chemistry.
[140] O. Hoffmann,et al. Amyloid β Peptide and Precursor Protein (APP) in Mild and Severe Brain Ischemia , 1997 .
[141] D. Holtzman,et al. Caspases: A treatment target for neurodegenerative disease? , 1997, Nature Medicine.
[142] H. Loetscher,et al. Presenilins Are Processed by Caspase-type Proteases* , 1997, The Journal of Biological Chemistry.
[143] R. Tanzi,et al. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. , 1997, Science.
[144] D. Price,et al. Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm , 1997, Nature.
[145] John Hardy,et al. Amyloid, the presenilins and Alzheimer's disease , 1997, Trends in Neurosciences.
[146] W. Markesbery,et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. , 1997, JAMA.
[147] J. Buxbaum,et al. Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins* , 1997, The Journal of Biological Chemistry.
[148] P. S. St George-Hyslop,et al. Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins* , 1997, The Journal of Biological Chemistry.
[149] A. Smith,et al. The Effects of Additional Pathology on the Cognitive Deficit in Alzheimer Disease , 1997, Journal of neuropathology and experimental neurology.
[150] Richard Hollister,et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease , 1997, Annals of neurology.
[151] C. Cotman,et al. Bax Protein Expression Is Increased in Alzheimer's Brain: Correlations with DNA Damage, Bcl‐2 Expression, and Brain Pathology , 1997, Journal of neuropathology and experimental neurology.
[152] M. Mattson,et al. Alzheimer's PS‐1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β‐peptide , 1996, Neuroreport.
[153] C. Miller,et al. The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. , 1996, FEBS letters.
[154] T. Hökfelt,et al. Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. , 1996, Neuroreport.
[155] I. Greenwald,et al. Membrane Topology of the C. elegans SEL-12 Presenilin , 1996, Neuron.
[156] B. Margolis,et al. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein , 1996, Molecular and cellular biology.
[157] E. Tani,et al. Cytotoxic Fragment of Amyloid Precursor Protein Accumulates in Hippocampus after Global Forebrain Ischemia , 1996, Journal of Cerebral Blood Flow and Metabolism.
[158] D. Borchelt,et al. Protein Topology of Presenilin 1 , 1996, Neuron.
[159] Y. Stern,et al. Risk factors for incident dementia after stroke. Role of hypoxic and ischemic disorders. , 1996, Stroke.
[160] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[161] D. Borchelt,et al. Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo , 1996, Neuron.
[162] E. Matsubara,et al. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[163] W. O'Fallon,et al. Dementia after ischemic stroke , 1996, Neurology.
[164] T. Russo,et al. The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein (*) , 1995, The Journal of Biological Chemistry.
[165] M. Adams,et al. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene , 1995, Neuroreport.
[166] J. Rommens,et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.
[167] G. Schellenberg,et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.
[168] D. Pollen,et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.
[169] Brian J Cummings,et al. Immunohistochemical evidence for apoptosis in Alzheimer's disease. , 1994, Neuroreport.
[170] R. Mayeux,et al. Risk of dementia after stroke in a hospitalized cohort , 1994, Neurology.
[171] J. Kimura,et al. Temporal Profiles of Accumulation of Amyloid β/A4 Protein Precursor in the Gerbil after Graded Ischemic Stress , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[172] N. Bohnen,et al. Alzheimer's Disease and Cumulative Exposure to Anesthesia: A Case‐Control Study , 1994, Journal of the American Geriatrics Society.
[173] K. Kogure,et al. Altered Gene Expression in Cerebral Ischemia , 1993, Stroke.
[174] K. Jellinger,et al. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients , 1993, Neuroscience Letters.
[175] P. Lansbury,et al. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.
[176] M. Pericak-Vance,et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[177] J. Weber,et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.
[178] Bradley T. Hyman,et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease , 1992, Neurology.
[179] D. Salmon,et al. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.
[180] R. Tanzi,et al. Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex , 1991, Neuroscience Letters.
[181] M. Pericak-Vance,et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.
[182] J. Trojanowski,et al. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.
[183] T. Oltersdorf,et al. Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.
[184] D. Price,et al. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.
[185] Andreas Weidemann,et al. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.
[186] D. Selkoe,et al. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[187] J. Walker,et al. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[188] S. Latt,et al. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. , 1987, Science.
[189] H. Wiśniewski,et al. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[190] G. Greisen,et al. Cerebral Blood Flow, PaCO2 Changes, and Visual Evoked Potentials in Mechanically Ventilated, Preterm Infants , 1987, Acta paediatrica Scandinavica.
[191] P. S. St George-Hyslop,et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.
[192] M. Lerman,et al. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. , 1987, Science.
[193] K. Grzeschik,et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.
[194] H. Wiśniewski,et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[195] D. Selkoe,et al. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[196] C. Masters,et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[197] G. Glenner,et al. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. , 1984, Biochemical and biophysical research communications.
[198] G. Glenner,et al. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .
[199] M. Kirschner,et al. A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.
[200] S. Wollman,et al. POSTOPERATIVE HUMAN REACTION TIME AND HYPOCARBIA DURING ANAESTHESIA , 1968 .
[201] R. Tanzi,et al. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 , 2007, Journal of Molecular Neuroscience.
[202] D. Selkoe,et al. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function , 2005, Nature Neuroscience.
[203] F. Panza,et al. LBP-1c/CP2/LSF gene polymorphism and risk of sporadic Alzheimer's disease. , 2004, Journal of neurology, neurosurgery, and psychiatry.
[204] S. M. de la Monte,et al. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. , 2003, Journal of Alzheimer's disease : JAD.
[205] M. Albert,et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. , 2003, Human molecular genetics.
[206] M. Wolfe. The secretases of Alzheimer's disease. , 2003, Current topics in developmental biology.
[207] M. Mattson. Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease. , 2002, International review of neurobiology.
[208] J. Wang,et al. The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosisin vitro , 2001, Irish journal of medical science.
[209] D L Price,et al. Alzheimer's disease: genetic studies and transgenic models. , 1998, Annual review of genetics.
[210] D. Price,et al. Mutant genes in familial Alzheimer's disease and transgenic models. , 1998, Annual review of neuroscience.
[211] Jonathan A. Cooper,et al. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development , 1997, The EMBO journal.
[212] Deborah S. Smith,et al. Parkinsonian symptoms during emergence from general anesthesia. , 1995, Anesthesiology.
[213] N. Bohnen,et al. Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. , 1994, The International journal of neuroscience.
[214] A. Alzheimer. Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .