Structure and function of DNA-binding proteins.

The past year has seen the determination of over three dozen new structures of DNA-binding proteins. Highlights of new structural motifs include the DNA-binding domain of p53 tumor suppressor and the amino-terminal fragment of Escherichia coli DNA topoisomerase I. Other structures illustrate variations of known structural motifs, including co-crystals of helix-turn-helix, basic helix-loop-helix, and zinc finger proteins.

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[58]  Stephen K. Burley,et al.  Co-crystal structure of TBP recognizing the minor groove of a TATA element , 1993, Nature.

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[61]  Xiaodong Cheng,et al.  Structure of PvuII endonuclease with cognate DNA. , 1994, The EMBO journal.

[62]  K. Struhl,et al.  The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex , 1992, Cell.

[63]  G. P. Mullen,et al.  Determination of the structure of the DNA binding domain of γΔ resolvase in solution , 1994 .

[64]  M. Schumacher,et al.  Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. , 1994, Science.

[65]  U Heinemann,et al.  Double helix conformation, groove dimensions and ligand binding potential of a G/C stretch in B-DNA. , 1992, The EMBO journal.

[66]  R. Bryan,et al.  The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments. , 1993 .

[67]  P. Kraulis,et al.  Structure of the HMG box motif in the B‐domain of HMG1. , 1993, EMBO Journal.

[68]  Steven Hahn,et al.  Crystal structure of a yeast TBP/TATA-box complex , 1993, Nature.

[69]  P. Wright,et al.  The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage λ repressor DNA-binding domain , 1993, Cell.

[70]  T. Steitz,et al.  Structure of DNA polymerase I Klenow fragment bound to duplex DNA , 1993, Science.

[71]  Richard J. Roberts,et al.  Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine , 1993, Cell.