A wireless actuating drug delivery system

A wireless actuating drug delivery system was devised. The system is based on induction heating for drug delivery. In this study, thermally generated nitrogen gas produced by induction heating of azobisisobutyronitrile (AIBN) was utilized for pressure-driven release of the drug. The delivery device consists of an actuator chamber, a drug reservoir, and a microchannel. A semicircular copper disc (5 and 6 mm in diameter and 100 µm thick), and thermal conductive tape were integrated as the heating element in the actuator chamber. The final device was 2.7 mm thick. 28 µl of drug solution were placed in the reservoir and the device released the drug quickly at the rate of 6 µl s−1 by induction heating at 160 µT of magnetic intensity. The entire drug solution was released and dispersed after subcutaneous implantation under identical experimental condition. This study demonstrates that the device was simply prepared and drug delivery could be achieved by wireless actuation of a thin, pressure-driven actuator.

[1]  M. Cima,et al.  A controlled-release microchip , 1999, Nature.

[2]  Po-Ying Li,et al.  A passive MEMS drug delivery pump for treatment of ocular diseases , 2009, Biomedical microdevices.

[3]  Jin-Woo Choi,et al.  A functional on-chip pressure generator using solid chemical propellant for disposable lab-on-a-chip. , 2003, Lab on a chip.

[4]  Yong-Kyu Yoon,et al.  A wireless sequentially actuated microvalve system , 2013 .

[5]  WonHyoung Ryu,et al.  Wet microcontact printing (µCP) for micro-reservoir drug delivery systems , 2013, Biofabrication.

[6]  Dennis L. Polla,et al.  Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology , 2001 .

[7]  Nan-Chyuan Tsai,et al.  Review of MEMS-based drug delivery and dosing systems , 2007 .

[8]  Jung-Hwan Park,et al.  Wireless induction heating in a microfluidic device for cell lysis. , 2010, Lab on a chip.

[9]  Robert Langer,et al.  In vivo release from a drug delivery MEMS device. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[10]  Babak Ziaie,et al.  Polymeric microdevices for transdermal and subcutaneous drug delivery. , 2012, Advanced drug delivery reviews.

[11]  N M Elman,et al.  An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care , 2009, Biomedical microdevices.

[12]  Roger C. Jones,et al.  Magnetic Induction Heating of Ferromagnetic Implants for Inducing Localized Hyperthermia in Deep-Seated Tumors , 1984, IEEE Transactions on Biomedical Engineering.

[13]  Rebecca S. Shawgo,et al.  BioMEMS for drug delivery , 2002 .

[14]  Susan Z. Hua,et al.  An electrolytically actuated micropump , 2004 .

[15]  Po-Ying Li,et al.  An electrochemical intraocular drug delivery device , 2008, 2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS).

[16]  Li Wang,et al.  Characteristics and fabrication of NiTi/Si diaphragm micropump , 2001 .

[17]  John F Schenck,et al.  Physical interactions of static magnetic fields with living tissues. , 2005, Progress in biophysics and molecular biology.

[18]  T. Desai,et al.  Bioadhesive Microdevices for Drug Delivery: A Feasibility Study , 2001 .

[19]  E. Meng,et al.  A Parylene Bellows Electrochemical Actuator , 2010, Journal of Microelectromechanical Systems.

[20]  L. Lin,et al.  A water-powered micro drug delivery system , 2004, Journal of Microelectromechanical Systems.

[21]  Mark G. Allen,et al.  Polymer Microneedles for Controlled-Release Drug Delivery , 2006, Pharmaceutical Research.

[22]  John T Santini,et al.  Electrothermally activated microchips for implantable drug delivery and biosensing. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[23]  N M Elman,et al.  Medical applications of implantable drug delivery microdevices based on MEMS (Micro-Electro-Mechanical-Systems). , 2010, Current pharmaceutical biotechnology.

[24]  A. Pisano,et al.  Water-powered, osmotic microactuator , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[25]  WonHyoung Ryu,et al.  Targeted electrohydrodynamic printing for micro-reservoir drug delivery systems , 2013 .

[26]  Mark R Prausnitz,et al.  Microneedles for transdermal drug delivery. , 2004, Advanced drug delivery reviews.

[27]  Eugene K. Ungar,et al.  A New Approach to Defining Human Touch Temperature Standards , 2010 .

[28]  Robert Langer,et al.  Small-scale systems for in vivo drug delivery , 2003, Nature Biotechnology.

[29]  Yogesh B Gianchandani,et al.  Transdermal power transfer for recharging implanted drug delivery devices via the refill port , 2010, Biomedical microdevices.

[30]  Nicholas A Peppas,et al.  Microfabricated drug delivery devices. , 2005, International journal of pharmaceutics.

[31]  Kenichi Takahata,et al.  Implantable drug delivery device using frequency-controlled wireless hydrogel microvalves , 2011, Biomedical microdevices.

[32]  T. Desai,et al.  Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[33]  P. Colombo,et al.  Novel Platforms for Oral Drug Delivery , 2009, Pharmaceutical Research.

[34]  D. Armani,et al.  Microfabrication technology for polycaprolactone, a biodegradable polymer , 2000 .