1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

[1]  T. Thippeswamy,et al.  Immediate epileptogenesis: Impact on brain in C57BL/6J mouse kainate model. , 2016, Frontiers in bioscience.

[2]  D. Janigro,et al.  Blood–brain barrier, bulk flow, and interstitial clearance in epilepsy , 2016, Journal of Neuroscience Methods.

[3]  X. Ji,et al.  Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia , 2016, Stroke.

[4]  R. Keep,et al.  Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage , 2015, Translational Stroke Research.

[5]  R. Franco,et al.  Alternatively activated microglia and macrophages in the central nervous system , 2015, Progress in Neurobiology.

[6]  T. Thippeswamy,et al.  Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry , 2015, PloS one.

[7]  J. Huguenard,et al.  Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction , 2015, Neurobiology of Disease.

[8]  C. Aoki,et al.  Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes , 2015, The Journal of Neuroscience.

[9]  Philippe Ryvlin,et al.  Epilepsy: new advances , 2015, The Lancet.

[10]  M. Bonini,et al.  Redox regulation of NF‐κB p50 and M1 polarization in microglia , 2015, Glia.

[11]  T. Thippeswamy,et al.  Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy , 2015, BioMed research international.

[12]  W. Le,et al.  Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases , 2015, Molecular Neurobiology.

[13]  R. Dingledine,et al.  Candidate drug targets for prevention or modification of epilepsy. , 2015, Annual review of pharmacology and toxicology.

[14]  M. O’Banion,et al.  Neuroinflammation and M2 microglia: the good, the bad, and the inflamed , 2014, Journal of Neuroinflammation.

[15]  U. Heinemann,et al.  Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration , 2014, Brain Structure and Function.

[16]  G. Sills,et al.  Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies , 2014, PloS one.

[17]  Milos Pekny,et al.  The dual role of astrocyte activation and reactive gliosis , 2014, Neuroscience Letters.

[18]  C. Rivard,et al.  Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy , 2014, Neurobiology of Disease.

[19]  A. Vezzani.  Epilepsy and Inflammation in the Brain: Overview and Pathophysiology , 2014, Epilepsy currents.

[20]  Felix Rosenow,et al.  Invasive EEG studies in tumor‐related epilepsy: When are they indicated and with what kind of electrodes? , 2013, Epilepsia.

[21]  M. Carson,et al.  Glial cells as primary therapeutic targets for epilepsy , 2013, Neurochemistry International.

[22]  R. Ransohoff,et al.  Development, maintenance and disruption of the blood-brain barrier , 2013, Nature Network Boston.

[23]  W. Löscher,et al.  Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy , 2013, Neurobiology of Disease.

[24]  A. Basu,et al.  Interleukin‐1β orchestrates underlying inflammatory responses in microglia via Krüppel‐like factor 4 , 2013, Journal of neurochemistry.

[25]  P. Buckmaster,et al.  High‐dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy , 2013, Epilepsia.

[26]  Asla Pitkänen,et al.  Epilepsy biomarkers , 2013, Epilepsia.

[27]  P. Gressens,et al.  Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro , 2013, Brain, Behavior, and Immunity.

[28]  A. Nehlig,et al.  Epilepsy therapy development: Technical and methodologic issues in studies with animal models , 2013, Epilepsia.

[29]  Nicola Marchi,et al.  Cerebrovascular Remodeling and Epilepsy , 2013, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[30]  H. Baba,et al.  The Prevalence and Phenotype of Activated Microglia/Macrophages within the Spinal Cord of the Hyperostotic Mouse (twy/twy) Changes in Response to Chronic Progressive Spinal Cord Compression: Implications for Human Cervical Compressive Myelopathy , 2013, PloS one.

[31]  Bing Li,et al.  Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat , 2013, Journal of Molecular Neuroscience.

[32]  J. Garthwaite,et al.  On the selectivity of neuronal NOS inhibitors , 2013, British journal of pharmacology.

[33]  Y. Sekino,et al.  L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation , 2012, Journal of Neuroinflammation.

[34]  G. Sills,et al.  N w‐Propyl‐l‐arginine (L‐NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses , 2012, The European journal of neuroscience.

[35]  R. Leak,et al.  Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia , 2012, Stroke.

[36]  G. Sperk,et al.  Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex , 2012, Neuropharmacology.

[37]  Chengsan Sun,et al.  Characterization of status epilepticus induced by two organophosphates in rats , 2012, Epilepsy Research.

[38]  U. Heinemann,et al.  Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy , 2012, Glia.

[39]  M. de Curtis,et al.  Seizure‐induced brain‐borne inflammation sustains seizure recurrence and blood–brain barrier damage , 2012, Annals of neurology.

[40]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[41]  M. J. Bández,et al.  Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system. , 2012, Neurotoxicology.

[42]  B. Barres,et al.  Genomic Analysis of Reactive Astrogliosis , 2012, The Journal of Neuroscience.

[43]  P. Buckmaster,et al.  Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy? , 2011, Epilepsia.

[44]  P. Kwan,et al.  Drug-resistant epilepsy. , 2011, The New England journal of medicine.

[45]  J. Bockaert,et al.  Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways , 2011, The Journal of Neuroscience.

[46]  Wolfgang Löscher,et al.  Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs , 2011, Seizure.

[47]  Jie Zhu,et al.  Kainic Acid-Induced Neurotoxicity: Targeting Glial Responses and Glia-Derived Cytokines , 2011, Current neuropharmacology.

[48]  I. Shelef,et al.  Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy , 2011, Cardiovascular psychiatry and neurology.

[49]  P. Buckmaster,et al.  Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy , 2011, The Journal of Neuroscience.

[50]  Y. Ben-Ari.  Kainate and temporal lobe epilepsies: Three decades of progress , 2010 .

[51]  P. Buckmaster,et al.  Mossy fiber sprouting in the dentate gyrus , 2010 .

[52]  R. Ransohoff,et al.  The myeloid cells of the central nervous system parenchyma , 2010, Nature.

[53]  Jean Gotman,et al.  Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system , 2010, Neurobiology of Disease.

[54]  Melinda E. Lull,et al.  Microglial activation and chronic neurodegeneration , 2010, Neurotherapeutics.

[55]  J. Quinn,et al.  The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro. , 2010, Histology and histopathology.

[56]  D. Treiman.  Management of refractory complex partial seizures: current state of the art , 2010, Neuropsychiatric disease and treatment.

[57]  Andrew White,et al.  EEG spike activity precedes epilepsy after kainate‐induced status epilepticus , 2010, Epilepsia.

[58]  Manisha N. Patel,et al.  Mitochondria, oxidative stress, and temporal lobe epilepsy , 2010, Epilepsy Research.

[59]  Jessica K. Alexander,et al.  Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord , 2009, The Journal of Neuroscience.

[60]  U. Heinemann,et al.  Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis? , 2009, The Journal of Neuroscience.

[61]  M. Shapira,et al.  Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis , 2009, The Journal of Neuroscience.

[62]  K. Albus,et al.  Endogenous Nitric Oxide Is a Key Promoting Factor for Initiation of Seizure-Like Events in Hippocampal and Entorhinal Cortex Slices , 2009, The Journal of Neuroscience.

[63]  Andrew M. White,et al.  Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus , 2009, The Journal of Neuroscience.

[64]  J. Quinn,et al.  Nitric Oxide Regulates Activity-Dependent Neuroprotective Protein (ADNP) in the Dentate Gyrus of the Rodent Model of Kainic Acid-Induced Seizure , 2009, Journal of Molecular Neuroscience.

[65]  R. Miles,et al.  Epileptiform activities in slices of hippocampus from mice after intra‐hippocampal injection of kainic acid , 2008, The Journal of physiology.

[66]  A. Vezzani,et al.  The role of cytokines in the pathophysiology of epilepsy , 2008, Brain, Behavior, and Immunity.

[67]  J. Quinn,et al.  Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure , 2008, Neurobiology of Disease.

[68]  A. X. Xie,et al.  Modeling CNS microglia: the quest to identify predictive models. , 2008, Drug discovery today. Disease models.

[69]  E. Aronica,et al.  Glia as a source of cytokines: Implications for neuronal excitability and survival , 2008, Epilepsia.

[70]  J. Forrester,et al.  Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. , 2007, Investigative ophthalmology & visual science.

[71]  J. Quinn,et al.  Nitric Oxide-NGF Mediated PPTA/SP, ADNP, and VIP Expression in the Peripheral Nervous System , 2007, Journal of Molecular Neuroscience.

[72]  Andrew M. White,et al.  Development of Spontaneous Seizures after Experimental Status Epilepticus: Implications for Understanding Epileptogenesis , 2007, Epilepsia.

[73]  T. Baram,et al.  New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy , 2007, Epilepsy currents.

[74]  E. Aronica,et al.  Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. , 2007, Brain : a journal of neurology.

[75]  Alon Friedman,et al.  TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. , 2007, Brain : a journal of neurology.

[76]  I. Han,et al.  IL‐1β, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF‐κB pathways , 2006 .

[77]  A. Shetty,et al.  Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy , 2006, Journal of neuroscience research.

[78]  J. Quinn,et al.  Nitric oxide, a biological double-faced janus--is this good or bad? , 2006, Histology and histopathology.

[79]  R. Sankar,et al.  Treatment of Experimental Status Epilepticus in Immature Rats: Dissociation Between Anticonvulsant and Antiepileptogenic Effects , 2006, Pediatric Research.

[80]  J. O'Callaghan,et al.  Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice , 2006, Brain Research.

[81]  A. Vezzani,et al.  Brain Inflammation in Epilepsy: Experimental and Clinical Evidence , 2005, Epilepsia.

[82]  A. Shetty,et al.  Repair of the Injured Adult Hippocampus through Graft-Mediated Modulation of the Plasticity of the Dentate Gyrus in a Rat Model of Temporal Lobe Epilepsy , 2005, The Journal of Neuroscience.

[83]  T. Dawson,et al.  Nitric oxide, S-nitrosylation and neurodegeneration. , 2005, Cellular and molecular biology.

[84]  S. Hagioka,et al.  Effects of 7-nitroindazole and N-nitro-l-arginine methyl ester on changes in cerebral blood flow and nitric oxide production preceding development of hyperbaric oxygen-induced seizures in rats , 2005, Neuroscience Letters.

[85]  Z. Emri,et al.  Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus , 2005, Experimental Neurology.

[86]  J. Velíšková,et al.  Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus , 2005, Epilepsia.

[87]  W. Gan,et al.  ATP mediates rapid microglial response to local brain injury in vivo , 2005, Nature Neuroscience.

[88]  T. Kayama,et al.  Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital , 2005, Epilepsy Research.

[89]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[90]  O. Hurtado,et al.  Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia , 2005, Neurobiology of Disease.

[91]  V. Besson,et al.  1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats. , 2005, Nitric oxide : biology and chemistry.

[92]  Jens P Dreier,et al.  Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex , 2004, The Journal of Neuroscience.

[93]  F Edward Dudek,et al.  Mossy Fiber Sprouting and Recurrent Excitation: Direct Electrophysiologic Evidence and Potential Implications , 2004, Epilepsy currents.

[94]  Wolfgang Löscher,et al.  The neurobiology of antiepileptic drugs , 2004, Nature Reviews Neuroscience.

[95]  J. Rothstein,et al.  Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. , 2003, Virology.

[96]  J. Weiss,et al.  Disruption of Glial Glutamate Transport by Reactive Oxygen Species Produced in Motor Neurons , 2003, The Journal of Neuroscience.

[97]  W. Pardridge.  Blood-brain barrier drug targeting: the future of brain drug development. , 2003, Molecular interventions.

[98]  D. Margineanu,et al.  Pilocarpine-induced epileptogenesis in the rat: Impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations , 2002, Epilepsy Research.

[99]  P. Buckmaster,et al.  Axon Sprouting in a Model of Temporal Lobe Epilepsy Creates a Predominantly Excitatory Feedback Circuit , 2002, The Journal of Neuroscience.

[100]  P. Camfield,et al.  Long‐term Outcome Is Unchanged by Antiepileptic Drug Treatment after a First Seizure: A 15‐year Follow‐up from a Randomized Trial in Childhood , 2002, Epilepsia.

[101]  Jorge D. Erusalimsky,et al.  Does nitric oxide modulate mitochondrial energy generation and apoptosis? , 2002, Nature Reviews Molecular Cell Biology.

[102]  S. Takashima,et al.  Different effects between 7-nitroindazole and l-NAME on cerebral hemodynamics and hippocampal lesions during kainic acid-induced seizures in newborn rabbits , 2001, Brain and Development.

[103]  Guy C. Brown,et al.  Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity , 2001, The Journal of Neuroscience.

[104]  W. Löscher,et al.  Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy , 2001, Epilepsy Research.

[105]  N. Temkin.  Antiepileptogenesis and Seizure Prevention Trials with Antiepileptic Drugs: Meta‐Analysis of Controlled Trials , 2001, Epilepsia.

[106]  W. Ulrich,et al.  The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. , 2000, Molecular pharmacology.

[107]  Y. Ben-Ari,et al.  Kainate, a double agent that generates seizures: two decades of progress , 2000, Trends in Neurosciences.

[108]  G. Sperk,et al.  Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[109]  Patrick Kwan,et al.  Epilepsy after the first drug fails: substitution or add-on? , 2000, Seizure.

[110]  C. Lipinski.  Drug-like properties and the causes of poor solubility and poor permeability. , 2000, Journal of pharmacological and toxicological methods.

[111]  S. Garattini,et al.  Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus , 2000, The European journal of neuroscience.

[112]  G. Smythe,et al.  Quantification of 3-nitrotyrosine in biological tissues and fluids: Generating valid results by eliminating artifactual formation , 2000, Journal of the American Society for Mass Spectrometry.

[113]  L. Schmued,et al.  Fluoro-Jade: Novel Fluorochromes for Detecting Toxicant-Induced Neuronal Degeneration , 2000, Toxicologic pathology.

[114]  M. Rathbone,et al.  Trophic effects of purines in neurons and glial cells , 1999, Progress in Neurobiology.

[115]  F. Dudek,et al.  Abnormal responses to perforant path stimulation in the dentate gyrus of slices from rats with kainate-induced epilepsy and mossy fiber reorganization , 1999, Epilepsy Research.

[116]  G. Böhme,et al.  Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury , 1999, British journal of pharmacology.

[117]  J. Nadler,et al.  Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth. , 1999, Journal of neurophysiology.

[118]  A. Seelig,et al.  Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion , 1998, The Journal of Membrane Biology.

[119]  F. Edward Dudek,et al.  Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy , 1998, Epilepsy Research.

[120]  E. Beghi,et al.  Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy , 1997, Neurology.

[121]  Richard Graham Knowles,et al.  1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo* , 1997, The Journal of Biological Chemistry.

[122]  F. Dudek,et al.  Electrographic Seizures and New Recurrent Excitatory Circuits in the Dentate Gyrus of Hippocampal Slices from Kainate-Treated Epileptic Rats , 1996, The Journal of Neuroscience.

[123]  T. Babb,et al.  Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining , 1996, Neuroreport.

[124]  C. Camfield,et al.  Does the number of seizures before treatment influence ease of control or remission of childhood epilepsy? Not if the number is 10 or less , 1996, Neurology.

[125]  M. Okazaki,et al.  Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin , 1995, The Journal of comparative neurology.

[126]  T. Dawson,et al.  Gases as biological messengers: nitric oxide and carbon monoxide in the brain , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[127]  J. Zimmer,et al.  Microglial and Astroglial Reactions to Ischemic and Kainic Acid-Induced Lesions of the Adult Rat Hippocampus , 1993, Experimental Neurology.

[128]  K. Boje,et al.  Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death , 1992, Brain Research.

[129]  M. Sperling,et al.  The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients , 1992, Brain Research.

[130]  R. S. Sloviter.  Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats , 1992, Neuroscience Letters.

[131]  E. Bertram,et al.  The hippocampus in experimental chronic epilepsy: A morphometric analysis , 1990, Annals of neurology.

[132]  G. Cascino,et al.  Mossy fiber synaptic reorganization in the epileptic human temporal lobe , 1989, Annals of neurology.

[133]  D. Tauck,et al.  Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[134]  G. Danscher,et al.  Histochemical demonstration of heavy metals , 1981, Histochemistry.

[135]  R. Racine,et al.  Modification of seizure activity by electrical stimulation. II. Motor seizure. , 1972, Electroencephalography and clinical neurophysiology.

[136]  B. Stoica,et al.  Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. , 2014, Journal of neuropathology and experimental neurology.

[137]  P. Buckmaster.  Does mossy fiber sprouting give rise to the epileptic state? , 2014, Advances in experimental medicine and biology.

[138]  E. Aronica,et al.  Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators , 2012 .

[139]  Michael A. Rogawski,et al.  Molecular targets for antiepileptic drug development , 2011, Neurotherapeutics.

[140]  F Edward Dudek,et al.  Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. , 2007, Progress in brain research.

[141]  E. Hansson,et al.  Astrocyte–endothelial interactions at the blood–brain barrier , 2006, Nature Reviews Neuroscience.

[142]  E. Cavalheiro,et al.  Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats , 2004, Experimental Brain Research.

[143]  S. Moncada,et al.  Inhibition of nitric oxide synthase as a potential therapeutic target. , 1999, Annual review of pharmacology and toxicology.

[144]  A. van Dam,et al.  Production, regulation and role of nitric oxide in glial cells. , 1998, Mediators of inflammation.

[145]  T. Dawson,et al.  Nitric oxide in neurodegeneration. , 1998, Progress in brain research.

[146]  P. Schwartzkroin,et al.  Ultrastructural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus , 1997, Hippocampus.

[147]  G. Mathern,et al.  Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development. , 1996, Epilepsy research. Supplement.