Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

[1]  B. Hadland,et al.  A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. , 2004, Blood.

[2]  S. Vercauteren,et al.  Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo. , 2004, Blood.

[3]  K. Ozono,et al.  Defective long‐term repopulating ability in hematopoietic stem cells lacking the Polycomb‐group gene rae28 , 2004, European journal of haematology.

[4]  H. Okano,et al.  Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. , 2004, Immunity.

[5]  P. Greengard,et al.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor , 2004, Nature Medicine.

[6]  R. Callahan,et al.  Notch Signaling in Mammary Gland Tumorigenesis , 2004, Journal of Mammary Gland Biology and Neoplasia.

[7]  C. Guidos,et al.  Notch signaling in development and disease , 2003, Clinical genetics.

[8]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[9]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[10]  L. Espinosa,et al.  Phosphorylation by Glycogen Synthase Kinase-3β Down-regulates Notch Activity, a Link for Notch and Wnt Pathways* , 2003, Journal of Biological Chemistry.

[11]  Carmen Birchmeier,et al.  beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. , 2003, Developmental biology.

[12]  S. Karlsson,et al.  Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4 , 2003, Molecular and Cellular Biology.

[13]  I. Weissman,et al.  Wnt proteins are lipid-modified and can act as stem cell growth factors , 2003, Nature.

[14]  I. Weissman,et al.  A role for Wnt signalling in self-renewal of haematopoietic stem cells , 2003, Nature.

[15]  S. Ogawa,et al.  Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. , 2003, Immunity.

[16]  W. Pear,et al.  Notch signaling in lymphopoiesis. , 2003, Seminars in immunology.

[17]  R. Moon,et al.  Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Hans Clevers,et al.  The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells , 2002, Cell.

[19]  John T. Dimos,et al.  A Stem Cell Molecular Signature , 2002, Science.

[20]  Anjen Chenn,et al.  Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors , 2002, Science.

[21]  J. Aster,et al.  An Invitation to T and More Notch Signaling in Lymphopoiesis , 2002, Cell.

[22]  D. Scadden,et al.  Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. , 2002, Blood.

[23]  I. Weissman,et al.  Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[24]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[25]  S. Jacobsen,et al.  Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. , 2001, Immunity.

[26]  E. Fuchs,et al.  Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. , 2001, Genes & development.

[27]  W. Birchmeier,et al.  β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin , 2001, Cell.

[28]  M. Bhatia,et al.  Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. , 2001, Blood.

[29]  G. Fishell,et al.  Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors. , 2001, Development.

[30]  James D. Griffin,et al.  MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors , 2000, Nature Genetics.

[31]  M. Bhatia,et al.  The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells , 2000, The Journal of experimental medicine.

[32]  I. Bernstein,et al.  Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling , 2000, Nature Medicine.

[33]  William C. Skarnes,et al.  An LDL-receptor-related protein mediates Wnt signalling in mice , 2000, Nature.

[34]  Andrew Tomlinson,et al.  arrow encodes an LDL-receptor-related protein essential for Wingless signalling , 2000, Nature.

[35]  Yoichi Kato,et al.  LDL-receptor-related proteins in Wnt signal transduction , 2000, Nature.

[36]  I. Weissman,et al.  Translating stem and progenitor cell biology to the clinic: barriers and opportunities. , 2000, Science.

[37]  I. Weissman,et al.  The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells , 2000, The Journal of experimental medicine.

[38]  B. Osborne,et al.  Notch and the immune system. , 1999, Immunity.

[39]  E. Fuchs,et al.  Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. , 1999, Development.

[40]  F. Watt,et al.  beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. , 1999, Development.

[41]  C. Albanese,et al.  The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[42]  H. Macdonald,et al.  Deficient T cell fate specification in mice with an induced inactivation of Notch1. , 1999, Immunity.

[43]  S. Artavanis-Tsakonas,et al.  Notch Signaling : Cell Fate Control and Signal Integration in Development , 1999 .

[44]  D. Selkoe,et al.  Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. , 1999, Biochemistry.

[45]  R. Grosschedl,et al.  Regulation of LEF-1/TCF transcription factors by Wnt and other signals. , 1999, Current opinion in cell biology.

[46]  Amico,et al.  The cyclin D1 gene is a target of the b-cateninyLEF-1 pathway , 1999 .

[47]  F. McCormick,et al.  Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. , 1999, Nature.

[48]  Hans Clevers,et al.  The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors , 1998, Nature.

[49]  Hans Clevers,et al.  Drosophila Tcf and Groucho interact to repress Wingless signalling activity , 1998, Nature.

[50]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[51]  Hans Clevers,et al.  Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 , 1998, Nature Genetics.

[52]  R. Nusse,et al.  β-catenin: a key mediator of Wnt signaling , 1998 .

[53]  K Willert,et al.  Beta-catenin: a key mediator of Wnt signaling. , 1998, Current opinion in genetics & development.

[54]  D. J. Van Den Berg,et al.  Role of members of the Wnt gene family in human hematopoiesis. , 1998, Blood.

[55]  R. Nusse,et al.  Mechanisms of Wnt signaling in development. , 1998, Annual review of cell and developmental biology.

[56]  R. Nusse,et al.  Wnt signaling: a common theme in animal development. , 1997, Genes & development.

[57]  R. Tekmal,et al.  Role of MMTV integration locus cellular genes in breast cancer. , 1997, Frontiers in bioscience : a journal and virtual library.

[58]  T. Austin,et al.  A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. , 1997, Blood.

[59]  K. Kinzler,et al.  Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.

[60]  Hans Clevers,et al.  Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC , 1997, Science.

[61]  D. Wettstein,et al.  The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. , 1997, Development.

[62]  Hiromitsu Nakauchi,et al.  Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell , 1996, Science.

[63]  A. S. Conner,et al.  Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo , 1996, The Journal of experimental medicine.

[64]  T. Mak,et al.  Disruption of the mouse RBP-J kappa gene results in early embryonic death. , 1995, Development.

[65]  Kenji Matsuno,et al.  Notch signaling. , 1995, Science.

[66]  A. M. Arias,et al.  Notch is required for wingless signaling in the epidermis of Drosophila , 1994, Cell.

[67]  I. Weissman,et al.  Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow , 1992, The Journal of experimental medicine.

[68]  H. Varmus,et al.  Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice , 1988, Cell.

[69]  I. Weissman,et al.  Purification and characterization of mouse hematopoietic stem cells. , 1988, Science.

[70]  J. Eliason,et al.  Isolation , 2024, Encyclopedia of Database Systems.

[71]  J. Till,et al.  A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS. , 1964, Proceedings of the National Academy of Sciences of the United States of America.