Microelectronics-Based Biosensors Dedicated to the Detection of Neurotransmitters: A Review

Dysregulation of neurotransmitters (NTs) in the human body are related to diseases such as Parkinson's and Alzheimer's. The mechanisms of several neurological disorders, such as epilepsy, have been linked to NTs. Because the number of diagnosed cases is increasing, the diagnosis and treatment of such diseases are important. To detect biomolecules including NTs, microtechnology, micro and nanoelectronics have become popular in the form of the miniaturization of medical and clinical devices. They offer high-performance features in terms of sensitivity, as well as low-background noise. In this paper, we review various devices and circuit techniques used for monitoring NTs in vitro and in vivo and compare various methods described in recent publications.

[1]  Shereen M. Azab,et al.  Carbon Paste Gold Nanoparticles Sensor for the Selective Determination of Dopamine in Buffered Solutions , 2010 .

[2]  Andreas Hierlemann,et al.  Multi-target electrochemical biosensing enabled by integrated CMOS electronics , 2011 .

[3]  Ming Ma,et al.  Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine. , 2012, Biosensors & bioelectronics.

[4]  Haluk Kulah,et al.  CMOS Cell Sensors for Point-of-Care Diagnostics , 2012, Sensors.

[5]  Silvana Andreescu,et al.  Electrochemical quantification of serotonin in the live embryonic zebrafish intestine. , 2010, Analytical chemistry.

[6]  Ioan Stamatin,et al.  Selective DPV Method of Dopamine Determination in Biological Samples Containing Ascorbic Acid , 2010 .

[7]  R. Thewes,et al.  CMOS chips for bio molecule sensing purposes , 2007, 2007 2nd International Workshop on Advances in Sensors and Interface.

[8]  Hua Wang,et al.  Integrated biosensors in CMOS , 2011, 2011 IEEE 54th International Midwest Symposium on Circuits and Systems (MWSCAS).

[9]  D. Carrié,et al.  First Evidence of Increased Plasma Serotonin Levels in Tako-Tsubo Cardiomyopathy , 2013, BioMed research international.

[10]  Oscar L Lopez,et al.  The growing burden of Alzheimer's disease. , 2011, The American journal of managed care.

[11]  R. Wightman,et al.  In vivo comparison of norepinephrine and dopamine release in rat brain by simultaneous measurements with fast‐scan cyclic voltammetry , 2011, Journal of neurochemistry.

[12]  Arjang Hassibi,et al.  Biosensor Systems in Standard CMOS Processes: Fact or Fiction? , 2009, IEEE Transactions on Industrial Electronics.

[13]  R. Adams,et al.  Probing brain chemistry with electroanalytical techniques. , 1976, Analytical chemistry.

[14]  Silvana Andreescu,et al.  Chitosan coated carbon fiber microelectrode for selective in vivo detection of neurotransmitters in live zebrafish embryos. , 2011, Analytica chimica acta.

[15]  Mohamad Sawan,et al.  An efficient time-based CMOS potentiostat for neurotransmitters sensing , 2013, 2013 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[16]  Zhifeng Fu,et al.  Highly sensitive trivalent copper chelate-luminol chemiluminescence system for capillary electrophoresis detection of epinephrine in the urine of smoker. , 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[17]  Ya-Ting Chung,et al.  An ultrasensitive nanowire-transistor biosensor for detecting dopamine release from living PC12 cells under hypoxic stimulation. , 2013, Journal of the American Chemical Society.

[18]  J A Cox,et al.  Chemical and biochemical sensors based on advances in materials chemistry. , 1999, Journal of pharmaceutical and biomedical analysis.

[19]  Yuepiao Cai,et al.  New integrated in vivo microdialysis-electrochemical device for determination of the neurotransmitter dopamine in rat striatum of freely moving rats , 2011 .

[20]  David Zenisek,et al.  Amperometric Resolution of a Prespike Stammer and Evoked Phases of Fast Release from Retinal Bipolar Cells , 2013, The Journal of Neuroscience.

[21]  W. Kutner,et al.  Electrochemically synthesized polymers in molecular imprinting for chemical sensing , 2012, Analytical and Bioanalytical Chemistry.

[22]  Pedram Mohseni,et al.  Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry. , 2009, Journal of neurosurgery.

[23]  Junsheng Yu,et al.  A molecule-imprinted polyaniline membrane modified on carbon fiber for detection of glycine. , 2014, Bio-medical materials and engineering.

[24]  Itaru Honma,et al.  Electrochemical biosensor based on protein-polysaccharide hybrid for selective detection of nanomolar dopamine metabolite of 3,4-dihydroxyphenylacetic acid (DOPAC) , 2005 .

[25]  Filiz Kuralay,et al.  The Recent Electrochemical Biosensor Technologies for Monitoring of Nucleic Acid Hybridization , 2011 .

[26]  Kurt V Gothelf,et al.  RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamine. , 2013, Analytical chemistry.

[27]  Michael S.-C. Lu,et al.  5×5 CMOS capacitive sensor array for detection of the neurotransmitter dopamine. , 2010, Biosensors & bioelectronics.

[28]  Hassan Hosseini Monfared,et al.  Electroless deposition of bis(4'-(4-Pyridyl)-2,2':6',2''-terpyridine)iron(II) thiocyanate complex onto carbon nanotubes modified glassy carbon electrode: application to simultaneous determination of ascorbic acid, dopamine and uric acid , 2011 .

[29]  Andreas Hierlemann,et al.  Impedance characterization and modeling of electrodes for biomedical applications , 2005, IEEE Transactions on Biomedical Engineering.

[30]  Pradyot Nandi,et al.  Development of a PDMS‐based microchip electrophoresis device for continuous online in vivo monitoring of microdialysis samples , 2010, Electrophoresis.

[31]  Claire M Schmerberg,et al.  Mass spectrometric detection of neuropeptides using affinity-enhanced microdialysis with antibody-coated magnetic nanoparticles. , 2013, Analytical chemistry.

[32]  Ashley E. Ross,et al.  Comparison of Nafion- and overoxidized polypyrrole-carbon nanotube electrodes for neurotransmitter detection , 2011 .

[33]  Graeme Eisenhofer,et al.  Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans , 2003, Journal of Pharmacology and Experimental Therapeutics.

[34]  Chang-Wen Huang,et al.  Electrochemical Detection of the Neurotransmitter Dopamine by Nanoimprinted Interdigitated Electrodes and a CMOS Circuit With Enhanced Collection Efficiency , 2011, IEEE Sensors Journal.

[35]  A. Andrews,et al.  Head-to-head comparisons of carbon fiber microelectrode coatings for sensitive and selective neurotransmitter detection by voltammetry. , 2011, Analytical chemistry.

[36]  Young-Min Shon,et al.  Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: proof of principle. , 2010, Journal of neurosurgery.

[37]  Shamsoddin Mohajerzadeh,et al.  Mediator-less highly sensitive voltammetric detection of glutamate using glutamate dehydrogenase/vertically aligned CNTs grown on silicon substrate. , 2012, Biosensors & bioelectronics.

[38]  P. He,et al.  Simultaneous Determination of Neuroactive Amino Acids in Serum by CZE Coupled with Amperometric Detection , 2013, Chromatographia.

[39]  T. Tseng,et al.  Selective enzyme immobilization on arrayed microelectrodes for the application of sensing neurotransmitters , 2013 .

[40]  Zhuang Liu,et al.  Carbon nanotubes in biology and medicine: An overview , 2012 .

[41]  Constantin Apetrei,et al.  AMPEROMETRIC TYROSINASE BASED BIOSENSORS FOR SEROTONIN DETECTION , 2013 .

[42]  Mohamad Sawan,et al.  Electrode robustness in artificial cerebrospinal fluid for dielectrophoresis-based LoC , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[43]  Harold G Monbouquette,et al.  Implantable Microprobe with Arrayed Microsensors for Combined Amperometric Monitoring of the Neurotransmitters, Glutamate and Dopamine. , 2012, Journal of electroanalytical chemistry.

[44]  H. Dai,et al.  Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery , 2009, Nano research.

[45]  Sunita Bishnoi,et al.  Simultaneous determination of epinephrine and norepinephrine in human blood plasma and urine samples using nanotubes modified edge plane pyrolytic graphite electrode. , 2011, Talanta.

[46]  Kevin E Bennet,et al.  Carbon nanofiber electrode array for electrochemical detection of dopamine using fast scan cyclic voltammetry. , 2011, The Analyst.

[47]  G. Gerhardt,et al.  Amperometric Measurement of Glutamate Release Modulation by Gabapentin and Pregabalin in Rat Neocortical Slices: Role of Voltage-Sensitive Ca2+ α2δ-1 Subunit , 2011, Journal of Pharmacology and Experimental Therapeutics.

[48]  Pavel Takmakov,et al.  Flexible software platform for fast-scan cyclic voltammetry data acquisition and analysis. , 2013, Analytical chemistry.

[49]  C. S. Henry,et al.  Characterization of Novel Microelectrode Geometries for Detection of Neurotransmitters , 2012, IEEE Sensors Journal.

[50]  Adam K Dengler,et al.  Microfabricated Microelectrode Sensor for Measuring Background and Slowly Changing Dopamine Concentrations. , 2013, Journal of electroanalytical chemistry.

[51]  S. B. Revin,et al.  Fabrication, characterization and application of a grafting based gold nanoparticles electrode for the selective determination of an important neurotransmitter , 2012 .

[52]  Donald E Ingber,et al.  Lab on a chip: United States of America. , 2012, Lab on a chip.

[53]  B. J. Venton,et al.  Rapid, sensitive detection of neurotransmitters at microelectrodes modified with self-assembled SWCNT forests. , 2012, Analytical chemistry.

[54]  Suw Young Ly,et al.  Determination of Epinephrine in Carp Brain Cells by Square-Wave Anodic Stripping Voltammetry with Carbon Nanotubes , 2012 .

[55]  Silvana Andreescu,et al.  Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments. , 2014, Biosensors & bioelectronics.

[56]  David Trebotich,et al.  Microdialysis Microneedles for Continuous Medical Monitoring , 2005, Biomedical microdevices.

[57]  Archita Patnaik,et al.  Interfacial Janus gold nanoclusters as excellent phase- and orientation-specific dopamine sensors. , 2012, The Analyst.

[58]  Minbaek Lee,et al.  Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. , 2010, Lab on a chip.

[59]  Kenneth P. Camilleri,et al.  Investigating linear superposition of multi-species neurotransmitter voltammetric measurements in-vitro , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[60]  J. L. Davidson,et al.  High temporal resolution electrochemical biosensor using nitrogen-incorporated nanodiamond ultra-microelectrode array , 2012, 2012 IEEE Sensors.

[61]  Manfred Lindau,et al.  Parallel recording of neurotransmitters release from chromaffin cells using a 10×10 CMOS IC potentiostat array with on-chip working electrodes. , 2013, Biosensors & bioelectronics.

[62]  Segyeong Joo,et al.  Chemical sensors with integrated electronics. , 2008, Chemical reviews.

[63]  D. Barbier,et al.  Immobilization method to preserve enzyme specificity in biosensors: consequences for brain glutamate detection. , 2013, Analytical chemistry.

[64]  L. Holland,et al.  Amperometric and voltammetric detection for capillary electrophoresis , 2002, Electrophoresis.

[65]  B. J. Venton,et al.  Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes. , 2011, The Analyst.

[66]  Jonathan V Sweedler,et al.  Microfluidic systems for studying neurotransmitters and neurotransmission. , 2013, Lab on a chip.

[67]  Ning Xia,et al.  Amplified voltammetric detection of dopamine using ferrocene-capped gold nanoparticle/streptavidin conjugates. , 2013, Biosensors & bioelectronics.

[68]  Jun Wang,et al.  Individually addressable thin-film ultramicroelectrode array for spatial measurements of single vesicle release. , 2013, Analytical chemistry.

[69]  Robert T Kennedy,et al.  Microfluidic electrophoresis chip coupled to microdialysis for in vivo monitoring of amino acid neurotransmitters. , 2005, Analytical chemistry.

[70]  John Taylor,et al.  Commercialisation of CMOS Integrated Circuit Technology in Multi-Electrode Arrays for Neuroscience and Cell-Based Biosensors , 2011, Sensors.

[71]  Fan-Gang Tseng,et al.  Nanocapillary electrophoretic electrochemical chip: towards analysis of biochemicals released by single cells , 2011, Interface Focus.

[72]  Shereen M. Azab,et al.  Electrochemical Determination of Neurotransmitters Using Gold Nanoparticles on Nafion/Carbon Paste Modified Electrode , 2012 .

[73]  M.S.-C. Lu,et al.  CMOS Capacitive Sensors With Sub- $\mu$m Microelectrodes for Biosensing Applications , 2010, IEEE Sensors Journal.

[74]  Serge Kokot,et al.  Application of multiway-variate calibration to simultaneous voltammetric determination of three catecholamines. , 2011, Analytical methods : advancing methods and applications.

[75]  Nephi Stella,et al.  Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals , 2009, Nature Methods.

[76]  E. Hirsch,et al.  Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[77]  Pradyot Nandi,et al.  Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: a review. , 2009, Analytica chimica acta.

[78]  S. Iijima.  Helical microtubules of graphitic carbon , 1991, Nature.

[79]  B. J. Venton,et al.  Review: Carbon nanotube based electrochemical sensors for biomolecules. , 2010, Analytica chimica acta.

[80]  S. G. Rosen,et al.  Epinephrine kinetics in humans: radiotracer methodology. , 1989, The Journal of clinical endocrinology and metabolism.

[81]  A. Dalton,et al.  Are carbon nanotubes a natural solution? Applications in biology and medicine. , 2013, ACS applied materials & interfaces.

[82]  Robert T. Kennedy,et al.  Collection of nanoliter microdialysate fractions in plugs for off-line in vivo chemical monitoring with up to 2s temporal resolution , 2010, Journal of Neuroscience Methods.

[83]  Sunita Bishnoi,et al.  A novel multi-walled carbon nanotube modified sensor for the selective determination of epinephrine in smokers , 2011 .

[84]  Hung Cao,et al.  An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters , 2012, IEEE Sensors Journal.

[85]  S. B. Revin,et al.  Electrochemical sensor for neurotransmitters at physiological pH using a heterocyclic conducting polymer modified electrode. , 2012, The Analyst.

[86]  Mohamad Sawan,et al.  Dielectrophoresis-Based Integrated Lab-on-Chip for Nano and Micro-Particles Manipulation and Capacitive Detection , 2012, IEEE Trans. Biomed. Circuits Syst..

[87]  R M Riggin,et al.  Electrochemical detection of selected organic components in the eluate from high-performance liquid-chromatography. , 1974, Clinical chemistry.

[88]  Abolhassan Noori,et al.  A cyclodextrin host-guest recognition approach to an electrochemical sensor for simultaneous quantification of serotonin and dopamine. , 2011, Biosensors & bioelectronics.

[89]  Taghi Khayamian,et al.  Highly selective determination of ascorbic acid, dopamine, and uric acid by differential pulse voltammetry using poly(sulfonazo III) modified glassy carbon electrode , 2010 .

[90]  Pavel Takmakov,et al.  Microfabricated FSCV-compatible microelectrode array for real-time monitoring of heterogeneous dopamine release. , 2010, The Analyst.

[91]  Julie V. Macpherson,et al.  Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. , 2010, Physical chemistry chemical physics : PCCP.

[92]  Roman Genov,et al.  192-channel CMOS neurochemical microarray , 2010, IEEE Custom Integrated Circuits Conference 2010.

[93]  Bhavik Anil Patel,et al.  Influence of different biological environments on the stability of serotonin detection on carbon-based electrodes , 2012 .

[94]  B. J. Venton,et al.  Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine. , 2012, The Analyst.

[95]  Bradley A. Minch,et al.  Post-CMOS Fabrication of Working Electrodes for On-Chip Recordings of Transmitter Release , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[96]  Hsien-Chang Chang,et al.  Modification of platinum microelectrode with molecularly imprinted over-oxidized polypyrrole for dopamine measurement in rat striatum , 2012 .

[97]  Kostas Kostarelos,et al.  Carbon nanotubes in medicine & biology - therapy and diagnostics. , 2013, Advanced drug delivery reviews.

[98]  Gyoung-Ja Lee,et al.  Neurotransmitter detection by enzyme-immobilized CNT-FET , 2009 .

[99]  P Langlois,et al.  Modification of standard CMOS technology for cell-based biosensors. , 2012, Biosensors & bioelectronics.

[100]  Francisco V. Fernández,et al.  Adaptive CMOS analog circuits for 4G mobile terminals - Review and state-of-the-art survey , 2009, Microelectron. J..

[101]  Jun Ohta,et al.  Implantable CMOS Biomedical Devices , 2009, Sensors.

[102]  R. Hintsche,et al.  Novel micromachined silicon sensor for continuous glucose monitoring. , 2005, Biosensors & bioelectronics.

[103]  Mohamad Sawan,et al.  A New Fully Differential CMOS Capacitance to Digital Converter for Lab-on-Chip Applications , 2015, IEEE Transactions on Biomedical Circuits and Systems.

[104]  Ali Babaei,et al.  A Sensitive Simultaneous Determination of Adrenalin and Paracetamol on a Glassy Carbon Electrode Coated with a Film of Chitosan/Room Temperature Ionic Liquid/Single-Walled Carbon Nanotubes Nanocomposite , 2011 .

[105]  Jinwoo Park,et al.  In vivo voltammetry monitoring of electrically evoked extracellular norepinephrine in subregions of the bed nucleus of the stria terminalis. , 2012, Journal of neurophysiology.

[106]  M. Meyyappan,et al.  Carbon Nanofiber Electrode for Neurochemical Monitoring , 2013, Molecular Neurobiology.

[107]  K. Olson,et al.  Neurotransmitters excreted in the urine as biomarkers of nervous system activity: Validity and clinical applicability , 2011, Neuroscience & Biobehavioral Reviews.

[108]  I. Cesarino,et al.  Biosensor Based on Electrocodeposition of Carbon Nanotubes/Polypyrrole/Laccase for Neurotransmitter Detection , 2013 .

[109]  M. Poustinchi,et al.  Low power noise immune circuit for implantable CMOS neurochemical sensor applied in neural prosthetics , 2011, 2011 5th International IEEE/EMBS Conference on Neural Engineering.

[110]  Huaifang Fang,et al.  Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection. , 2011, Analytical chemistry.