Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

[1]  R. Glen,et al.  Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. , 1995, Journal of molecular biology.

[2]  P. Greengard,et al.  Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. , 2004, Journal of medicinal chemistry.

[3]  P Willett,et al.  Development and validation of a genetic algorithm for flexible docking. , 1997, Journal of molecular biology.

[4]  S. Rault,et al.  First synthesis of arylpyrrolo- and pyrazolopyrrolizinones as useful agents with potential biological interest , 2004 .

[5]  P. Renard,et al.  Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents. , 2004, Journal of medicinal chemistry.

[6]  S. Knapp,et al.  Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors. , 2003, Journal of molecular biology.

[7]  R. Cramer,et al.  Validation of the general purpose tripos 5.2 force field , 1989 .

[8]  S. Rault,et al.  Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents. , 2006, Bioorganic & medicinal chemistry.

[9]  Theodor Curtius 20. Hydrazide und Azide organischer Säuren I. Abhandlung , 1894 .

[10]  Jana Sopkova-de Oliveira Santos,et al.  3D-QSAR and Docking Studies of Selective GSK-3beta Inhibitors. Comparison with a Thieno[2, 3-b]pyrrolizinone Derivative, a New Potential Lead for GSK-3beta Ligands , 2005, J. Chem. Inf. Model..

[11]  Jana Sopkova-de Oliveira Santos,et al.  Synthesis and Biological Evaluation of Thienopyrrolizines, a New Family of CDK/GSK-3 Inhibitors , 2004, Journal of enzyme inhibition and medicinal chemistry.

[12]  E. Beckmann Zur Kenntniss der Isonitrosoverbindungen , 1887 .

[13]  F. Eloy,et al.  Synthèse d'isocarbostyriles et de chloro‐1‐isoquinoléines , 1969 .

[14]  K. F. Schmidt Über den Imin-Rest , 1924 .

[15]  J. Weinstock Notes- A Modified Curtious Reaction , 1961 .

[16]  P. Renard,et al.  Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents. , 2001, Bioorganic & medicinal chemistry letters.