The area of bioimaging and signal processing (BISP) is concerned with the development of dedicated tools for biomedical and bioinformatics applications and with fostering interdisciplinary and integrative approaches of biomedical topics by bridging the biology, medicine, and SP communities [1]. Increasingly sophisticated imaging devices and protocols are now being developed for biological and medical imaging. Understanding functional and pathological mechanisms in patients or model organisms indeed requires being able to visualize and measure in vivo and in situ at scales ranging from subcellular to whole body. A similar trend occurs in the area of genomics and proteomics, where sophisticated bioinformatics methods are required to assemble, decipher, and compare data from large-scale sequencing data [2]. This article focuses on the latest developments in biomedical imaging that has sparked a full array of challenging topics for the signal and image processing community.