A photoacoustic imaging system employing a curved-phased ultrasonic array and parallel electronics

Real-time photoacoustic imaging requires ultrasonic array receivers and parallel data acquisition systems for the simultaneous detection of weak photoacoustic signals. In this paper, we introduce a newly completed ultrasonic receiving array system and report preliminary results of our measured point spread function. The system employs a curved ultrasonic phased array consisting of 128-elements, which span a quarter of a complete circle. The center frequency of the array is 5 MHz and the bandwidth is greater than 60%. In order to maximize the signal-to-noise ratio for photoacoustic signal detection, we utilized special designs for the analog front-end electronics. First, the 128 transducer-element signals were routed out using a 50-Ohm impedance matching PCB board to sustain signal integrity. We also utilize 128 low-noise pre-amplifiers, connected directly to the ultrasonic transducer, to amplify the weak photoacoustic signals before they were multiplexed to a variable-gain multi-stage amplifier chain. All front-end circuits were placed close to the transducer array to minimize signal lose due to cables and therefore improve the signal-to-noise ratio. Sixteen analog-to-digital converters were used to sample signals at a rate of 40 mega-samples per second with a resolution of 10-bits per sample. This allows us to perform a complete electronic scan of all 128 elements using just eight laser pulses.

[1]  Geng Ku,et al.  Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact. , 2003, Optics letters.

[2]  Quing Zhu,et al.  A novel electronic architecture used to support biomedical photo-acoustic imaging , 2006, 2006 IEEE International Symposium on Circuits and Systems.

[3]  Renbiao Wu,et al.  Time-delay- and time-reversal-based robust capon beamformers for ultrasound imaging , 2005, IEEE Transactions on Medical Imaging.

[4]  Stefan A. Carp,et al.  Optoacoustic imaging using interferometric measurement of surface displacement , 2004 .

[5]  R. Kruger,et al.  Photoacoustic ultrasound (PAUS)--reconstruction tomography. , 1995, Medical physics.

[6]  Minghua Xu,et al.  Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment. , 2002, Medical physics.

[7]  Da Xing,et al.  Photoacoustic imaging with deconvolution algorithm. , 2004, Physics in medicine and biology.

[8]  Gerald J. Diebold,et al.  Photoacoustic Waveforms Generated by Fluid Bodies , 1992 .

[9]  G. Gonzalez Microwave Transistor Amplifiers: Analysis and Design , 1984 .

[10]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[11]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .

[12]  Robert A. Kruger,et al.  Thermoacoustic Molecular Imaging of Small Animals , 2003 .

[13]  Geng Ku,et al.  Multiple-bandwidth photoacoustic tomography. , 2004, Physics in medicine and biology.

[14]  C.G. Oakley,et al.  Calculation of ultrasonic transducer signal-to-noise ratios using the KLM model , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  John G. Proakis,et al.  Digital signal processing - principles, algorithms and applications (2. ed.) , 1992 .

[16]  Peter J. Fish Electronic Noise and Low Noise Design , 1993 .

[17]  Vasilis Ntziachristos,et al.  Quantitative point source photoacoustic inversion formulas for scattering and absorbing media. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[18]  J. Folkman Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.