Alfred P. Sloan Jr. prize. Studies and prospectives of the protein kinase C family for cellular regulation

[1]  Y. Nishizuka,et al.  Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). , 1989, The Journal of biological chemistry.

[2]  Y. Nishizuka,et al.  Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids. , 1988, Molecular endocrinology.

[3]  Y. Nishizuka,et al.  Distinct cellular expression of beta I- and beta II-subspecies of protein kinase C in rat cerebellum , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[4]  Y. Nishizuka,et al.  Properties of protein kinase C subspecies in human platelets. , 1988, Biochemical and biophysical research communications.

[5]  Y. Nishizuka,et al.  Differential down‐regulation of protein kinase C subspecies in KM3 cells , 1988, FEBS letters.

[6]  Y. Nishizuka,et al.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation , 1988, Nature.

[7]  Y. Nishizuka,et al.  Isolation of protein kinase C subspecies from a preparation of human T lymphocytes , 1988, FEBS letters.

[8]  Y. Nishizuka,et al.  The structure, expression, and properties of additional members of the protein kinase C family. , 1988, The Journal of biological chemistry.

[9]  Y. Nishizuka,et al.  Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain. , 1988, Journal of biochemistry.

[10]  Y. Nishizuka,et al.  The heterogeneity of protein kinase C in various rat tissues. , 1988, Biochemical and biophysical research communications.

[11]  W. Wilkison,et al.  Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA , 1988, Cell.

[12]  Mark D. Johnson,et al.  Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts , 1988, Cell.

[13]  Y. Nishizuka,et al.  Distribution of protein kinase C-like immunoreactive neurons in rat brain , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  A. W. Murray,et al.  Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C , 1987, Nature.

[15]  P. Cobbold,et al.  Phorbol-ester-induced alterations of free calcium ion transients in single rat hepatocytes. , 1987, The Biochemical journal.

[16]  Y. Nishizuka,et al.  Characterization of protein kinase C from normal and transformed cultured murine fibroblasts. , 1987, Biochemical and biophysical research communications.

[17]  A. Ullrich,et al.  Down-regulation of protein kinase C is due to an increased rate of degradation. , 1987, The Biochemical journal.

[18]  Y. Nishizuka,et al.  Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain , 1987, FEBS letters.

[19]  Y. Nishizuka,et al.  Expression and properties of two types of protein kinase C: alternative splicing from a single gene. , 1987, Science.

[20]  W. Young,et al.  Distinct patterns of expression of different protein kinase C mRNAs in rat tissues , 1987, Cell.

[21]  H. Kawasaki,et al.  Tissue-specific expression of three distinct types of rabbit protein kinase C , 1987, Nature.

[22]  J. Schlessinger,et al.  Allosteric regulation of the epidermal growth factor receptor kinase , 1986, The Journal of cell biology.

[23]  F. Huang,et al.  Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[24]  A. Ullrich,et al.  The complete primary structure of protein kinase C--the major phorbol ester receptor. , 1986, Science.

[25]  R. Kriz,et al.  Cloning and expression of multiple protein kinase C cDNAs , 1986, Cell.

[26]  Y. Nishizuka Studies and perspectives of protein kinase C. , 1986, Science.

[27]  S. Snyder,et al.  Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J. Berg,et al.  Potential metal-binding domains in nucleic acid binding proteins. , 1986, Science.

[29]  B. Horecker,et al.  The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid. , 1986, The Journal of biological chemistry.

[30]  M. Ingelman-Sundberg,et al.  Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. , 1986, Biochemical and biophysical research communications.

[31]  R. Ballester,et al.  Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate. , 1985, The Journal of biological chemistry.

[32]  M. Crumpton,et al.  Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Y. Nishizuka,et al.  Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes. , 1985, The Journal of biological chemistry.

[34]  Michael J. Berridge,et al.  Inositol trisphosphate, a novel second messenger in cellular signal transduction , 1984, Nature.

[35]  E. Rozengurt,et al.  Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells. , 1984, Biochemical and biophysical research communications.

[36]  Y. Nishizuka The role of protein kinase C in cell surface signal transduction and tumour promotion , 1984, Nature.

[37]  M. James,et al.  Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Y. Nishizuka,et al.  Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. , 1983, The Journal of biological chemistry.

[39]  J. J. Sando,et al.  Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[40]  C. Ashendel,et al.  Identification of a calcium- and phospholipid- dependent phorbol ester binding activity in the soluble fraction of mouse tissues. , 1983, Biochemical and biophysical research communications.

[41]  P. Blumberg,et al.  Regional localization by light microscopic autoradiography of receptors in mouse brain for phorbol ester tumor promoters. , 1983, Cancer letters.

[42]  Y. Nishizuka,et al.  Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease. , 1983, The Journal of biological chemistry.

[43]  Y Nishizuka,et al.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. , 1982, The Journal of biological chemistry.

[44]  P. Blumberg In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. , 1980, Critical reviews in toxicology.

[45]  Y. Nishizuka,et al.  Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. , 1977, The Journal of biological chemistry.

[46]  R. Michell Inositol phospholipids and cell surface receptor function. , 1975, Biochimica et biophysica acta.

[47]  R. O. Friedel,et al.  Acetylcholine action: biochemical aspects. , 1969, Science.

[48]  L. Hokin,et al.  Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. , 1953, The Journal of biological chemistry.

[49]  T. Hunter Protein-Tryosine Kinases , 1985 .

[50]  J. Niedel,et al.  Phorbol diester receptor copurifies with protein kinase C. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[51]  B. L. Duuren Tumor-promoting agents in two-stage carcinogenesis. , 1969 .

[52]  I. Berenblum The Cocarcinogenic Action of Croton Resin , 1941 .